Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099228825> ?p ?o ?g. }
- W2099228825 endingPage "E402" @default.
- W2099228825 startingPage "E397" @default.
- W2099228825 abstract "The cytokine interleukin (IL)-6 can increase markedly in the circulation during exercise, but whether the liver is a source of this increase is unknown. The aim of this study was to measure IL-6 flux across the hepatosplanchnic tissues in humans. To elevate systemic concentrations of IL-6, six healthy male subjects performed 120 min of semirecumbent cycling, and blood samples were simultaneously obtained from a brachial artery and the hepatic vein before and during exercise for the analysis of IL-6. Hepatosplanchnic blood flow (HBF) was measured using the indocyanine green infusion technique. Net hepatosplanchnic IL-6 balance was calculated from these measures. HBF was 1.3 +/- 0.1 l/min at rest and was not reduced throughout exercise, averaging 1.1 +/- 0.2 l/min. Arterial plasma IL-6 markedly increased (P < 0.05) from 1.8 +/- 0.6 ng/l at rest to 14.3 +/- 3.2 ng/l after 120 min of exercise. The hepatosplanchnic viscera did not contribute to this increase, since there was a net hepatosplanchnic IL-6 uptake (0.8 +/- 0.3 vs. 5.5 +/- 1.9 ng/min, rest vs. 120 min; P < 0.05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6." @default.
- W2099228825 created "2016-06-24" @default.
- W2099228825 creator A5005923405 @default.
- W2099228825 creator A5008622478 @default.
- W2099228825 creator A5013388710 @default.
- W2099228825 creator A5050361725 @default.
- W2099228825 creator A5060905663 @default.
- W2099228825 creator A5069566851 @default.
- W2099228825 creator A5074362044 @default.
- W2099228825 creator A5078474678 @default.
- W2099228825 date "2003-08-01" @default.
- W2099228825 modified "2023-09-26" @default.
- W2099228825 title "Hepatosplanchnic clearance of interleukin-6 in humans during exercise" @default.
- W2099228825 cites W1506036490 @default.
- W2099228825 cites W1866388644 @default.
- W2099228825 cites W1964940524 @default.
- W2099228825 cites W1968595533 @default.
- W2099228825 cites W1968643760 @default.
- W2099228825 cites W1972689256 @default.
- W2099228825 cites W1995937403 @default.
- W2099228825 cites W1998962160 @default.
- W2099228825 cites W2001955029 @default.
- W2099228825 cites W2003295057 @default.
- W2099228825 cites W2031529174 @default.
- W2099228825 cites W2040901874 @default.
- W2099228825 cites W2045622306 @default.
- W2099228825 cites W2050337618 @default.
- W2099228825 cites W2053765850 @default.
- W2099228825 cites W2059536686 @default.
- W2099228825 cites W2064316942 @default.
- W2099228825 cites W2067813522 @default.
- W2099228825 cites W2079220817 @default.
- W2099228825 cites W2086682722 @default.
- W2099228825 cites W2088094751 @default.
- W2099228825 cites W2099490660 @default.
- W2099228825 cites W2122726077 @default.
- W2099228825 cites W2125961211 @default.
- W2099228825 cites W2127647469 @default.
- W2099228825 cites W2130248772 @default.
- W2099228825 cites W2131088469 @default.
- W2099228825 cites W2132607881 @default.
- W2099228825 cites W2142562381 @default.
- W2099228825 cites W2149631937 @default.
- W2099228825 cites W2150082019 @default.
- W2099228825 cites W2162505253 @default.
- W2099228825 cites W2167880402 @default.
- W2099228825 cites W2168755719 @default.
- W2099228825 cites W2169741460 @default.
- W2099228825 cites W2223567557 @default.
- W2099228825 cites W2285204915 @default.
- W2099228825 cites W2402097036 @default.
- W2099228825 cites W2443487756 @default.
- W2099228825 cites W4252306180 @default.
- W2099228825 doi "https://doi.org/10.1152/ajpendo.00134.2003" @default.
- W2099228825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12857677" @default.
- W2099228825 hasPublicationYear "2003" @default.
- W2099228825 type Work @default.
- W2099228825 sameAs 2099228825 @default.
- W2099228825 citedByCount "68" @default.
- W2099228825 countsByYear W20992288252012 @default.
- W2099228825 countsByYear W20992288252013 @default.
- W2099228825 countsByYear W20992288252014 @default.
- W2099228825 countsByYear W20992288252015 @default.
- W2099228825 countsByYear W20992288252016 @default.
- W2099228825 countsByYear W20992288252017 @default.
- W2099228825 countsByYear W20992288252018 @default.
- W2099228825 countsByYear W20992288252019 @default.
- W2099228825 countsByYear W20992288252020 @default.
- W2099228825 countsByYear W20992288252021 @default.
- W2099228825 countsByYear W20992288252022 @default.
- W2099228825 countsByYear W20992288252023 @default.
- W2099228825 crossrefType "journal-article" @default.
- W2099228825 hasAuthorship W2099228825A5005923405 @default.
- W2099228825 hasAuthorship W2099228825A5008622478 @default.
- W2099228825 hasAuthorship W2099228825A5013388710 @default.
- W2099228825 hasAuthorship W2099228825A5050361725 @default.
- W2099228825 hasAuthorship W2099228825A5060905663 @default.
- W2099228825 hasAuthorship W2099228825A5069566851 @default.
- W2099228825 hasAuthorship W2099228825A5074362044 @default.
- W2099228825 hasAuthorship W2099228825A5078474678 @default.
- W2099228825 hasBestOaLocation W20992288252 @default.
- W2099228825 hasConcept C126322002 @default.
- W2099228825 hasConcept C134018914 @default.
- W2099228825 hasConcept C158846371 @default.
- W2099228825 hasConcept C2777604165 @default.
- W2099228825 hasConcept C71924100 @default.
- W2099228825 hasConcept C84393581 @default.
- W2099228825 hasConceptScore W2099228825C126322002 @default.
- W2099228825 hasConceptScore W2099228825C134018914 @default.
- W2099228825 hasConceptScore W2099228825C158846371 @default.
- W2099228825 hasConceptScore W2099228825C2777604165 @default.
- W2099228825 hasConceptScore W2099228825C71924100 @default.
- W2099228825 hasConceptScore W2099228825C84393581 @default.
- W2099228825 hasIssue "2" @default.
- W2099228825 hasLocation W20992288251 @default.
- W2099228825 hasLocation W20992288252 @default.
- W2099228825 hasLocation W20992288253 @default.
- W2099228825 hasOpenAccess W2099228825 @default.