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• W2099242898 startingPage "1707" @default.
• W2099242898 abstract "MeCP2 is an abundant protein that binds to methylated cytosine residues in DNA and regulates transcription. Mutations in MECP2 cause Rett syndrome, a severe neurological disorder that affects approximately 1:10 000 females. Mice lacking MeCP2 have been generated and constitute important models of Rett syndrome. However, it is yet unclear whether certain physiological events are sensitive to a decrease, rather than a complete lack of MeCP2. Here we report that a Mecp2 floxed allele (Mecp2lox) that was generated to allow conditional mutagenesis behaves as a hypomorph and the corresponding mutant mice exhibit phenotypical alterations including body weight gain, motor abnormalities and altered social behavior. Our data reinforce the view that the central nervous system is extremely sensitive to MeCP2 expression levels and suggest that the 3′-UTR of Mecp2 might contain important elements that contribute to the regulation of its stability or processing." @default.
• W2099242898 created "2016-06-24" @default.
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• W2099242898 date "2008-03-04" @default.
• W2099242898 modified "2023-10-05" @default.
• W2099242898 title "Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice" @default.
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• W2099242898 doi "https://doi.org/10.1093/hmg/ddn061" @default.
• W2099242898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18321865" @default.
• W2099242898 hasPublicationYear "2008" @default.
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