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• W2099244865 abstract "So, with an abundance of high quality scientific literature supporting significant bioactivity of multiple food components, what are the reasons for a generalized distrust of dietary supplements for prevention and management of disease? Clearly one component must be a discomfort with the overwhelming abundance of minimally regulated, poorly supported (or completely unsupported) claims and implications driven by marketers rather than by sound science. However, even conservative, evidence based claims are generally met with skepticism in the nutritional science community. This is a community with a cornerstone belief in the value of healthy diets (despite our disagreements surrounding what constitutes a healthy diet), rather than utilizing food components in a medicinal fashion. And yet, we continue to investigate food-derived bioactivity and to proclaim its potential value in our grant applications and our published manuscripts. It is now time to take an active role in translating these studies, both positive and negative, into useful, practical approaches that can be utilized as a benchmark for assessing supplement claims. Let us use Resveratrol as an example. This polyphenol, found in the skin of red grapes and other fruits, has been widely demonstrated to serve as a Sirt1 activator, mimicking the effects of energy restriction on lifespan and multiple metabolic outcomes, including diabetes [1-5]. However, most of these effects are only achieved at very high doses that are difficult to obtain in humans, while limited bioavailability and rapid metabolism make achieving therapeutically effective plasma levels a significant challenge. Consequently, promising results from cellular and rodent studies with very high concentrations of this polyphenol are not easily translated to human outcomes, and more reasonable doses have been reported to have little or no effect [6]. However, this has not prevented extensive marketing of resveratrol at doses unlikely to provide meaningful effects. Notably, some (albeit a minority) dietary supplements offer demonstrated efficacy with the doses used in the formulations, but these risks are getting lost in the larger universe of questionable supplements. The Nutritional Science community has a role to play in helping both health professionals and consumers that navigate this universe. As a starting point, here are some modest principles to be considered for benchmarking supplements:" @default.
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• W2099244865 date "2012-01-01" @default.
• W2099244865 modified "2023-09-30" @default.
• W2099244865 title "Dietary Supplements in Management and Prevention of Chronic Disease" @default.
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• W2099244865 doi "https://doi.org/10.4172/2161-0509.1000e107" @default.
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