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- W2099245280 abstract "ABSTRACT Bacterial cell-to-cell communication facilitates coordinated expression of specific genes in a growth rate-II and cell density-dependent manner, a process known as quorum sensing. While the discovery of a diffusible Escherichia coli signaling pheromone, termed autoinducer 2 (AI-2), has been made along with several quorum sensing genes, the overall number and coordination of genes controlled by quorum sensing through the AI-2 signal has not been studied systematically. We investigated global changes in mRNA abundance elicited by the AI-2 signaling molecule through the use of a luxS mutant that was unable to synthesize AI-2. Remarkably, 242 genes, comprising ca. 5.6% of the E. coli genome, exhibited significant transcriptional changes (either induction or repression) in response to a 300-fold AI-2 signaling differential, with many of the identified genes displaying high induction levels (more than fivefold). Significant induction of ygeV , a putative ς 54 -dependent transcriptional activator, and yhbH , a ς 54 modulating protein, suggests ς 54 may be involved in E. coli quorum sensing." @default.
- W2099245280 created "2016-06-24" @default.
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- W2099245280 date "2001-09-15" @default.
- W2099245280 modified "2023-10-07" @default.
- W2099245280 title "DNA Microarray-Based Identification of Genes Controlled by Autoinducer 2-Stimulated Quorum Sensing in <i>Escherichia coli</i>" @default.
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- W2099245280 doi "https://doi.org/10.1128/jb.183.18.5239-5247.2001" @default.
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