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• W2099248609 abstract "Hydroxamates (R-CONHOH) have been scarcely investigated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs). An inhibition/structural study of PhCONHOH is reported against all human isoforms. Comparing aliphatic (R = Me and CF(3)) and aromatic (R = Ph) hydroxamates as CAIs, we prove that CONHOH is a versatile zinc binding group. Depending on the nature of the R moiety, it can adopt different coordination modes to the catalytic ion within the CA active site." @default.
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• W2099248609 date "2012-01-01" @default.
• W2099248609 modified "2023-10-14" @default.
• W2099248609 title "Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors" @default.
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• W2099248609 doi "https://doi.org/10.1039/c2cc34275h" @default.
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