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• W2099279637 abstract "We have observed that oestradiol concentrations in breast and endometrial tumours are relatively higher than oestrone, in contrast to peripheral tissues. Infusion of radiolabelled oestrogen also suggested there was a difference in metabolism between normal and tumour tissue. We have therefore looked for factors which could modulate tissue steroid metabolism and conclude that progesterone may influence aromatase, and that the adrenal androgens can inhibit oestradiol dehydrogenase activity. The latter mechanism, in particular, may be important in increasing tissue exposure to oestradiol." @default.
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• W2099279637 date "1986-11-01" @default.
• W2099279637 modified "2023-10-14" @default.
• W2099279637 title "The role of tissue steroids in regulating aromatase and oestradiol 17β-hydroxysteroid dehydrogenase activities in breast and endometrial cancer" @default.
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• W2099279637 doi "https://doi.org/10.1016/0022-4731(86)90309-2" @default.
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