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• W2099282022 endingPage "1182" @default.
• W2099282022 startingPage "1170" @default.
• W2099282022 abstract "Most human cancers involve either mutational activation of the Ras oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway. Paradoxically, tumors that harbor Ras mutations almost invariably retain expression of a wild-type pRB protein. We explain this phenomenon by demonstrating that Ras-induced oncogenic transformation surprisingly depends on functional pRB protein. Cells lacking pRB are less susceptible to the oncogenic actions of H-RasV12 than wild-type cells and activated Ras has an inhibitory effect on the proliferation of pRB-deficient human tumor cells. In addition, depletion of pRB from Ras-transformed murine cells or human tumor cells that harbor Ras pathway mutations inhibits their proliferation and anchorage-independent growth. In sharp contrast to pRB-/- 3T3 cells, fibroblasts deficient in other pRB family members (p107 and p130) are more susceptible to Ras-mediated transformation than wild-type 3T3 cells. Moreover, loss of pRB in tumor cells harboring a Ras mutation results in increased expression of p107, and overexpression of p107 but not pRB strongly inhibits proliferation of these tumor cells. Together, these findings suggest that pRB and p107 have distinct roles in Ras-mediated transformation and suggest a novel tumor-suppressive role for p107 in the context of activated Ras." @default.
• W2099282022 created "2016-06-24" @default.
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• W2099282022 date "2006-02-01" @default.
• W2099282022 modified "2023-09-27" @default.
• W2099282022 title "The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformation" @default.
• W2099282022 cites W103445271 @default.
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• W2099282022 cites W1513463586 @default.
• W2099282022 cites W1570481371 @default.
• W2099282022 cites W1595981097 @default.
• W2099282022 cites W190015672 @default.
• W2099282022 cites W1937037006 @default.
• W2099282022 cites W1966040713 @default.
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• W2099282022 cites W197395184 @default.
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• W2099282022 cites W1983348452 @default.
• W2099282022 cites W1984948591 @default.
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• W2099282022 cites W1994840092 @default.
• W2099282022 cites W1995819749 @default.
• W2099282022 cites W2001004678 @default.
• W2099282022 cites W2003886366 @default.
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• W2099282022 cites W2015291011 @default.
• W2099282022 cites W2029080338 @default.
• W2099282022 cites W2033369330 @default.
• W2099282022 cites W2034440981 @default.
• W2099282022 cites W2035975217 @default.
• W2099282022 cites W2038500217 @default.
• W2099282022 cites W2044588457 @default.
• W2099282022 cites W2044646351 @default.
• W2099282022 cites W2046085471 @default.
• W2099282022 cites W2049783958 @default.
• W2099282022 cites W2051506850 @default.
• W2099282022 cites W2055998880 @default.
• W2099282022 cites W2058184498 @default.
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• W2099282022 cites W2070831760 @default.
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• W2099282022 cites W2075279572 @default.
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• W2099282022 cites W2081412587 @default.
• W2099282022 cites W2082382637 @default.
• W2099282022 cites W2086096251 @default.
• W2099282022 cites W2086322317 @default.
• W2099282022 cites W2087404852 @default.
• W2099282022 cites W2090427824 @default.
• W2099282022 cites W2092492901 @default.
• W2099282022 cites W2095849929 @default.
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• W2099282022 cites W2121228733 @default.
• W2099282022 cites W2124614845 @default.
• W2099282022 cites W2129223886 @default.
• W2099282022 cites W2131308181 @default.
• W2099282022 cites W2131368686 @default.
• W2099282022 cites W2135981246 @default.
• W2099282022 cites W2141596803 @default.
• W2099282022 cites W2147131744 @default.
• W2099282022 cites W2150451425 @default.
• W2099282022 cites W2150802330 @default.
• W2099282022 cites W2151812144 @default.
• W2099282022 cites W2153586332 @default.
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• W2099282022 cites W2157127419 @default.
• W2099282022 cites W2159594827 @default.
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• W2099282022 cites W2168441639 @default.
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• W2099282022 doi "https://doi.org/10.1128/mcb.26.4.1170-1182.2006" @default.
• W2099282022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1367176" @default.
• W2099282022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16449633" @default.
• W2099282022 hasPublicationYear "2006" @default.
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