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• W2099291451 abstract "Host-adapted strains of Salmonella are capable of establishing a persistent infection in their host often in the absence of clinical disease. The mouse model of Salmonella infection has primarily been used as a model for the acute systemic disease. Therefore, the sites of long-term S. typhimurium persistence in the mouse are not known nor are the mechanisms of persistent infection clearly understood. Here, we show that S. typhimurium can persist for as long as 1 yr in the mesenteric lymph nodes (MLNs) of 129sv Nramp1(+)(/)(+) (Slc11a1(+)(/)(+)) mice despite the presence of high levels of anti-S. typhimurium antibody. Tissues from 129sv mice colonized for 60 d contain numerous inflammatory foci and lesions with features resembling S. typhi granulomas. Tissues from mice infected for 365 d have very few organized inflammatory lesions, but the bacteria continue to persist within macrophages in the MLN and the animals generally remain disease-free. Finally, chronically infected mice treated with an interferon-gamma neutralizing antibody exhibited symptoms of acute systemic infection, with evidence of high levels of bacterial replication in most tissues and high levels of fecal shedding. Thus, interferon-gamma, which may affect the level of macrophage activation, plays an essential role in the control of the persistent S. typhimurium infection in mice." @default.
• W2099291451 created "2016-06-24" @default.
• W2099291451 creator A5010248908 @default.
• W2099291451 creator A5031762888 @default.
• W2099291451 creator A5088938146 @default.
• W2099291451 date "2004-01-19" @default.
• W2099291451 modified "2023-10-02" @default.
• W2099291451 title "<i>Salmonella typhimurium</i> Persists within Macrophages in the Mesenteric Lymph Nodes of Chronically Infected <i>Nramp1</i>+<i>/</i>+ Mice and Can Be Reactivated by IFNγ Neutralization" @default.
• W2099291451 cites W1504182415 @default.
• W2099291451 cites W1531480112 @default.
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• W2099291451 cites W1649341603 @default.
• W2099291451 cites W1863369254 @default.
• W2099291451 cites W1878895457 @default.
• W2099291451 cites W1902026070 @default.
• W2099291451 cites W1916462614 @default.
• W2099291451 cites W1947143056 @default.
• W2099291451 cites W1966408108 @default.
• W2099291451 cites W1966894462 @default.
• W2099291451 cites W1971681859 @default.
• W2099291451 cites W1985316610 @default.
• W2099291451 cites W1989511723 @default.
• W2099291451 cites W1989820671 @default.
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• W2099291451 cites W2037442091 @default.
• W2099291451 cites W2038692332 @default.
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• W2099291451 doi "https://doi.org/10.1084/jem.20031319" @default.
• W2099291451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2211772" @default.
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• W2099291451 hasPublicationYear "2004" @default.
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