Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099293847> ?p ?o ?g. }
- W2099293847 endingPage "1061" @default.
- W2099293847 startingPage "1052" @default.
- W2099293847 abstract "Breast cancer is the most prevalent cancer in women worldwide with a high mortality rate, and the identification of new biomarkers and targets for this disease is greatly needed. Here we present evidence that microtubule-associated protein (MAP) 7 domain-containing protein 3 (Mdp3) is highly expressed in clinical samples and cell lines of breast cancer. The expression of Mdp3 correlates with clinicopathological parameters indicating breast cancer malignancy. In addition, Mdp3 promotes breast cancer cell proliferation and motility in vitro and stimulates breast cancer growth and metastasis in mice. Mechanistic studies reveal that γ-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. These findings suggest a critical role for Mdp3 in the growth and metastasis of breast cancer and may have important implications for the management of this disease." @default.
- W2099293847 created "2016-06-24" @default.
- W2099293847 creator A5000409712 @default.
- W2099293847 creator A5003499278 @default.
- W2099293847 creator A5007035858 @default.
- W2099293847 creator A5017353282 @default.
- W2099293847 creator A5022169204 @default.
- W2099293847 creator A5040954728 @default.
- W2099293847 creator A5058127847 @default.
- W2099293847 creator A5065615188 @default.
- W2099293847 creator A5071184125 @default.
- W2099293847 creator A5072728610 @default.
- W2099293847 date "2014-01-01" @default.
- W2099293847 modified "2023-10-11" @default.
- W2099293847 title "Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis" @default.
- W2099293847 cites W1501874901 @default.
- W2099293847 cites W1979487028 @default.
- W2099293847 cites W1981777994 @default.
- W2099293847 cites W1985034396 @default.
- W2099293847 cites W1987045145 @default.
- W2099293847 cites W1994265469 @default.
- W2099293847 cites W1994840091 @default.
- W2099293847 cites W1997980682 @default.
- W2099293847 cites W2004105273 @default.
- W2099293847 cites W2010873092 @default.
- W2099293847 cites W2013346204 @default.
- W2099293847 cites W2030916076 @default.
- W2099293847 cites W2037834300 @default.
- W2099293847 cites W2040512792 @default.
- W2099293847 cites W2040679153 @default.
- W2099293847 cites W2046786106 @default.
- W2099293847 cites W2047370811 @default.
- W2099293847 cites W2048939997 @default.
- W2099293847 cites W2049135828 @default.
- W2099293847 cites W2051147623 @default.
- W2099293847 cites W2054688293 @default.
- W2099293847 cites W2059822676 @default.
- W2099293847 cites W2061516335 @default.
- W2099293847 cites W2076176011 @default.
- W2099293847 cites W2079078036 @default.
- W2099293847 cites W2106787323 @default.
- W2099293847 cites W2106890990 @default.
- W2099293847 cites W2113080446 @default.
- W2099293847 cites W2124371549 @default.
- W2099293847 cites W2136155557 @default.
- W2099293847 cites W2138078973 @default.
- W2099293847 cites W2162010595 @default.
- W2099293847 cites W2164890615 @default.
- W2099293847 doi "https://doi.org/10.7150/thno.9727" @default.
- W2099293847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143944" @default.
- W2099293847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25161703" @default.
- W2099293847 hasPublicationYear "2014" @default.
- W2099293847 type Work @default.
- W2099293847 sameAs 2099293847 @default.
- W2099293847 citedByCount "28" @default.
- W2099293847 countsByYear W20992938472014 @default.
- W2099293847 countsByYear W20992938472015 @default.
- W2099293847 countsByYear W20992938472016 @default.
- W2099293847 countsByYear W20992938472017 @default.
- W2099293847 countsByYear W20992938472018 @default.
- W2099293847 countsByYear W20992938472019 @default.
- W2099293847 countsByYear W20992938472020 @default.
- W2099293847 countsByYear W20992938472021 @default.
- W2099293847 crossrefType "journal-article" @default.
- W2099293847 hasAuthorship W2099293847A5000409712 @default.
- W2099293847 hasAuthorship W2099293847A5003499278 @default.
- W2099293847 hasAuthorship W2099293847A5007035858 @default.
- W2099293847 hasAuthorship W2099293847A5017353282 @default.
- W2099293847 hasAuthorship W2099293847A5022169204 @default.
- W2099293847 hasAuthorship W2099293847A5040954728 @default.
- W2099293847 hasAuthorship W2099293847A5058127847 @default.
- W2099293847 hasAuthorship W2099293847A5065615188 @default.
- W2099293847 hasAuthorship W2099293847A5071184125 @default.
- W2099293847 hasAuthorship W2099293847A5072728610 @default.
- W2099293847 hasBestOaLocation W20992938471 @default.
- W2099293847 hasConcept C10447061 @default.
- W2099293847 hasConcept C118646709 @default.
- W2099293847 hasConcept C121608353 @default.
- W2099293847 hasConcept C126322002 @default.
- W2099293847 hasConcept C143998085 @default.
- W2099293847 hasConcept C20418707 @default.
- W2099293847 hasConcept C2779013556 @default.
- W2099293847 hasConcept C2779399171 @default.
- W2099293847 hasConcept C29537977 @default.
- W2099293847 hasConcept C502942594 @default.
- W2099293847 hasConcept C530470458 @default.
- W2099293847 hasConcept C54355233 @default.
- W2099293847 hasConcept C58207958 @default.
- W2099293847 hasConcept C62112901 @default.
- W2099293847 hasConcept C71924100 @default.
- W2099293847 hasConcept C86803240 @default.
- W2099293847 hasConcept C95444343 @default.
- W2099293847 hasConcept C96232424 @default.
- W2099293847 hasConceptScore W2099293847C10447061 @default.
- W2099293847 hasConceptScore W2099293847C118646709 @default.
- W2099293847 hasConceptScore W2099293847C121608353 @default.
- W2099293847 hasConceptScore W2099293847C126322002 @default.
- W2099293847 hasConceptScore W2099293847C143998085 @default.