FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099300699> ?p ?o ?g. }

• W2099300699 endingPage "317" @default.
• W2099300699 startingPage "312" @default.
• W2099300699 abstract "Allopurinol is a uric acid lowering drug used in the treatment of gout and the prevention of tumor lysis syndrome. Allopurinol and its active metabolite oxipurinol inhibit xanthine oxidase, which forms uric acid from xanthine and hypoxanthine. Therapeutic drug monitoring is an important option for evaluation and optimization of allopurinol treatment in case of renal impairment, interaction with uricosuric drugs or to verify patient adherence. In this study we developed and validated a simple quantitative assay using reverse phased high-performance liquid chromatography (HPLC) with UV-detection as a method for quantification of allopurinol and oxipurinol in human serum in the presence of different frequently used drugs. The HPLC–UV method uses a mobile phase consisting of sodium acetate (0.02 M; pH 4.5), at a flow rate of 1.0 mL/min. Allopurinol and oxipurinol are detected by UV-absorption at 254 nm with a retention time of 9.9 min for oxipurinol and 12.3 min for allopurinol. Aciclovir is used as internal standard. Validation showed for allopurinol lower and upper limits of quantification of 0.5 and 10 mg/L and for oxipurinol 1 and 40 mg/L, respectively. The assay was linear over the concentration range of 0.5–10 mg/L (allopurinol) and 1–40 mg/L (oxipurinol). Intra- and inter-day precision showed coefficients of variation <15% over the complete concentration range; accuracy was within 5% for allopurinol and oxipurinol. Endogenous purine-like compounds were separated from allopurinol, oxipurinol and aciclovir with a resolution factor >1.5. Exogenous purine-like compounds and co-medication frequently used by gout patients did not hinder the analysis due to the dichloromethane washing step or to low UV-absorpion at 253 nm. Serum levels of 66 patients prescribed allopurinol 300 mg/day were determined using this HPLC–UV method. Measured serum allopurinol and oxipurinol concentrations in clinical practice showed large variability with a range of <0.5–4.3 mg/L for allopurinol and <1.0–39.2 mg/L for oxipurinol, respectively. We developed an easy-to-operate and validated HPLC–UV method for the quantification of allopurinol and oxipurinol in human serum. This method was proven to be valid for samples of gout patients frequently using concomitant medications." @default.
• W2099300699 created "2016-06-24" @default.
• W2099300699 creator A5008395067 @default.
• W2099300699 creator A5019028031 @default.
• W2099300699 creator A5039628503 @default.
• W2099300699 creator A5075965403 @default.
• W2099300699 creator A5081300145 @default.
• W2099300699 creator A5089962390 @default.
• W2099300699 creator A5090959094 @default.
• W2099300699 date "2007-10-01" @default.
• W2099300699 modified "2023-09-26" @default.
• W2099300699 title "A simple method for quantification of allopurinol and oxipurinol in human serum by high-performance liquid chromatography with UV-detection" @default.
• W2099300699 cites W1940381250 @default.
• W2099300699 cites W1964410175 @default.
• W2099300699 cites W1972956425 @default.
• W2099300699 cites W1981970630 @default.
• W2099300699 cites W1994812722 @default.
• W2099300699 cites W2002030526 @default.
• W2099300699 cites W2012551445 @default.
• W2099300699 cites W2034582867 @default.
• W2099300699 cites W2043374304 @default.
• W2099300699 cites W2062465859 @default.
• W2099300699 cites W2068530452 @default.
• W2099300699 cites W2080721371 @default.
• W2099300699 cites W2081764619 @default.
• W2099300699 cites W2094748514 @default.
• W2099300699 cites W2098144815 @default.
• W2099300699 cites W2116064354 @default.
• W2099300699 cites W2150343898 @default.
• W2099300699 cites W2162095352 @default.
• W2099300699 cites W4229797689 @default.
• W2099300699 doi "https://doi.org/10.1016/j.jpba.2007.08.002" @default.
• W2099300699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17890037" @default.
• W2099300699 hasPublicationYear "2007" @default.
• W2099300699 type Work @default.
• W2099300699 sameAs 2099300699 @default.
• W2099300699 citedByCount "34" @default.
• W2099300699 countsByYear W20993006992012 @default.
• W2099300699 countsByYear W20993006992013 @default.
• W2099300699 countsByYear W20993006992014 @default.
• W2099300699 countsByYear W20993006992015 @default.
• W2099300699 countsByYear W20993006992016 @default.
• W2099300699 countsByYear W20993006992017 @default.
• W2099300699 countsByYear W20993006992018 @default.
• W2099300699 countsByYear W20993006992019 @default.
• W2099300699 countsByYear W20993006992020 @default.
• W2099300699 countsByYear W20993006992021 @default.
• W2099300699 countsByYear W20993006992022 @default.
• W2099300699 countsByYear W20993006992023 @default.
• W2099300699 crossrefType "journal-article" @default.
• W2099300699 hasAuthorship W2099300699A5008395067 @default.
• W2099300699 hasAuthorship W2099300699A5019028031 @default.
• W2099300699 hasAuthorship W2099300699A5039628503 @default.
• W2099300699 hasAuthorship W2099300699A5075965403 @default.
• W2099300699 hasAuthorship W2099300699A5081300145 @default.
• W2099300699 hasAuthorship W2099300699A5089962390 @default.
• W2099300699 hasAuthorship W2099300699A5090959094 @default.
• W2099300699 hasBestOaLocation W20993006992 @default.
• W2099300699 hasConcept C126322002 @default.
• W2099300699 hasConcept C179998833 @default.
• W2099300699 hasConcept C181199279 @default.
• W2099300699 hasConcept C185592680 @default.
• W2099300699 hasConcept C2778102346 @default.
• W2099300699 hasConcept C2779470414 @default.
• W2099300699 hasConcept C2779881121 @default.
• W2099300699 hasConcept C2780261098 @default.
• W2099300699 hasConcept C2781116151 @default.
• W2099300699 hasConcept C43617362 @default.
• W2099300699 hasConcept C55493867 @default.
• W2099300699 hasConcept C71924100 @default.
• W2099300699 hasConcept C98274493 @default.
• W2099300699 hasConceptScore W2099300699C126322002 @default.
• W2099300699 hasConceptScore W2099300699C179998833 @default.
• W2099300699 hasConceptScore W2099300699C181199279 @default.
• W2099300699 hasConceptScore W2099300699C185592680 @default.
• W2099300699 hasConceptScore W2099300699C2778102346 @default.
• W2099300699 hasConceptScore W2099300699C2779470414 @default.
• W2099300699 hasConceptScore W2099300699C2779881121 @default.
• W2099300699 hasConceptScore W2099300699C2780261098 @default.
• W2099300699 hasConceptScore W2099300699C2781116151 @default.
• W2099300699 hasConceptScore W2099300699C43617362 @default.
• W2099300699 hasConceptScore W2099300699C55493867 @default.
• W2099300699 hasConceptScore W2099300699C71924100 @default.
• W2099300699 hasConceptScore W2099300699C98274493 @default.
• W2099300699 hasIssue "2" @default.
• W2099300699 hasLocation W20993006991 @default.
• W2099300699 hasLocation W20993006992 @default.
• W2099300699 hasLocation W20993006993 @default.
• W2099300699 hasOpenAccess W2099300699 @default.
• W2099300699 hasPrimaryLocation W20993006991 @default.
• W2099300699 hasRelatedWork W145487393 @default.
• W2099300699 hasRelatedWork W1994945627 @default.
• W2099300699 hasRelatedWork W2007385407 @default.
• W2099300699 hasRelatedWork W2008095130 @default.
• W2099300699 hasRelatedWork W2063014250 @default.
• W2099300699 hasRelatedWork W2079378515 @default.
• W2099300699 hasRelatedWork W2475268662 @default.
• W2099300699 hasRelatedWork W2765766885 @default.

• next