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- W2099304384 abstract "The Nek family of cell-cycle kinases is widely represented in eukaryotes and includes numerous proteins that were described only recently and remain poorly characterized. Comparing Neks in the context of clades allows us to examine the question of whether microbial eukaryotic Neks, although not strictly orthologs of their vertebrate counterparts, can provide clues to ancestral functions that might be retained in the vertebrate Neks. Relatives of the Nek2/NIMA proteins play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation. Nek6, Nek7 and Nek9 also seem to regulate mitosis. By contrast, Nek1 and Nek8 have been linked with polycystic kidney disease. Results of statistical analysis indicate that the family coevolved with centrioles that function as both microtubule-organizing centers and the basal bodies of cilia. This evolutionary perspective, taken together with functional studies of microbial Neks, provides new insights into the cellular roles of the proteins and disease with which some of them have been linked." @default.
- W2099304384 created "2016-06-24" @default.
- W2099304384 creator A5021180436 @default.
- W2099304384 creator A5074341050 @default.
- W2099304384 date "2005-11-15" @default.
- W2099304384 modified "2023-10-15" @default.
- W2099304384 title "Caught Nek-ing: cilia and centrioles" @default.
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- W2099304384 doi "https://doi.org/10.1242/jcs.02681" @default.
- W2099304384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16280549" @default.
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