FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099331835> ?p ?o ?g. }

• W2099331835 endingPage "1831" @default.
• W2099331835 startingPage "1822" @default.
• W2099331835 abstract "To review the efficacy, safety, pharmacologic, and pharmacokinetic data of agomelatine to better understand its potential role in the treatment of patients with major depressive disorder.A MEDLINE search (1966-October 2008) was conducted using the following terms: agomelatine, antidepressant, S20098, melatonin, serotonin, 5-HT(2C), MT, efficacy, safety, adverse effect, pharmacology, pharmacokinetic, receptor binding, depression, major depressive disorder, and mood disorder.All articles in English identified from the data sources were evaluated. Randomized, controlled trials involving humans were prioritized in the review. The references of published articles identified in the initial search process were also examined for any additional studies appropriate for the review.Agomelatine, a potent agonist at type 1 and 2 melatonin receptors, selectively inhibits serotonin. It is extensively metabolized via cytochrome P450 isoenyzmes 1A1, 1A2, and 2C9 to metabolites with less activity than the parent drug. Five randomized controlled studies were identified that examined the efficacy and safety of agomelatine in major depressive disorder. In general, agomelatine was found to produce significant improvements in depressive symptoms compared with placebo on many, but not all, rating scales. Three of the trials had active comparator arms (ie, venlafaxine, paroxetine). In these 3 investigations, agomelatine produced effects on depressive symptoms similar to those of the comparator drugs. A small number of studies have demonstrated sleep benefits with the use of agomelatine in depressed patients. Positive findings also exist for the use of agomelatine in seasonal affective disorder and bipolar depression. The most common adverse effects reported with agomelatine use were headache, nasopharyngitis, and gastrointestinal complaints. The magnitude of agomelatine-related adverse effects appears to be at least similar to some currently marketed antidepressants.Overall, agomelatine is a promising and well-tolerated medication for the treatment of major depressive disorder. More large-scale controlled trials are needed to gain a better understanding of the relative efficacy and safety of agomelatine." @default.
• W2099331835 created "2016-06-24" @default.
• W2099331835 creator A5015672760 @default.
• W2099331835 creator A5033425681 @default.
• W2099331835 creator A5053821334 @default.
• W2099331835 date "2008-11-18" @default.
• W2099331835 modified "2023-10-17" @default.
• W2099331835 title "Agomelatine Treatment of Major Depressive Disorder" @default.
• W2099331835 cites W1580029690 @default.
• W2099331835 cites W1964666670 @default.
• W2099331835 cites W1965988574 @default.
• W2099331835 cites W1977708183 @default.
• W2099331835 cites W1982665253 @default.
• W2099331835 cites W1994792053 @default.
• W2099331835 cites W1995403973 @default.
• W2099331835 cites W1998894503 @default.
• W2099331835 cites W2000023854 @default.
• W2099331835 cites W2009259832 @default.
• W2099331835 cites W2022032351 @default.
• W2099331835 cites W2022083293 @default.
• W2099331835 cites W2023518349 @default.
• W2099331835 cites W2025224792 @default.
• W2099331835 cites W2030313035 @default.
• W2099331835 cites W2031809759 @default.
• W2099331835 cites W2034737967 @default.
• W2099331835 cites W2035467193 @default.
• W2099331835 cites W2037264357 @default.
• W2099331835 cites W2037831322 @default.
• W2099331835 cites W2052098936 @default.
• W2099331835 cites W2052487000 @default.
• W2099331835 cites W2060126636 @default.
• W2099331835 cites W2063056774 @default.
• W2099331835 cites W2065813249 @default.
• W2099331835 cites W2070631875 @default.
• W2099331835 cites W2072188825 @default.
• W2099331835 cites W2080350725 @default.
• W2099331835 cites W2080424914 @default.
• W2099331835 cites W2084088430 @default.
• W2099331835 cites W2085321777 @default.
• W2099331835 cites W2087371709 @default.
• W2099331835 cites W2089441939 @default.
• W2099331835 cites W2090310653 @default.
• W2099331835 cites W2094469738 @default.
• W2099331835 cites W2097252156 @default.
• W2099331835 cites W2101544610 @default.
• W2099331835 cites W2103044052 @default.
• W2099331835 cites W2103431948 @default.
• W2099331835 cites W2120729007 @default.
• W2099331835 cites W2130100911 @default.
• W2099331835 cites W2132270063 @default.
• W2099331835 cites W2135297770 @default.
• W2099331835 cites W2137296158 @default.
• W2099331835 cites W2143247032 @default.
• W2099331835 cites W2149402043 @default.
• W2099331835 cites W2163789824 @default.
• W2099331835 cites W2411513431 @default.
• W2099331835 cites W2416693632 @default.
• W2099331835 cites W3187516820 @default.
• W2099331835 cites W4230100419 @default.
• W2099331835 cites W4231622706 @default.
• W2099331835 doi "https://doi.org/10.1345/aph.1l296" @default.
• W2099331835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19033480" @default.
• W2099331835 hasPublicationYear "2008" @default.
• W2099331835 type Work @default.
• W2099331835 sameAs 2099331835 @default.
• W2099331835 citedByCount "64" @default.
• W2099331835 countsByYear W20993318352012 @default.
• W2099331835 countsByYear W20993318352013 @default.
• W2099331835 countsByYear W20993318352014 @default.
• W2099331835 countsByYear W20993318352015 @default.
• W2099331835 countsByYear W20993318352016 @default.
• W2099331835 countsByYear W20993318352018 @default.
• W2099331835 countsByYear W20993318352019 @default.
• W2099331835 countsByYear W20993318352020 @default.
• W2099331835 countsByYear W20993318352021 @default.
• W2099331835 countsByYear W20993318352023 @default.
• W2099331835 crossrefType "journal-article" @default.
• W2099331835 hasAuthorship W2099331835A5015672760 @default.
• W2099331835 hasAuthorship W2099331835A5033425681 @default.
• W2099331835 hasAuthorship W2099331835A5053821334 @default.
• W2099331835 hasConcept C118552586 @default.
• W2099331835 hasConcept C126322002 @default.
• W2099331835 hasConcept C168563851 @default.
• W2099331835 hasConcept C197934379 @default.
• W2099331835 hasConcept C2776466888 @default.
• W2099331835 hasConcept C2778182776 @default.
• W2099331835 hasConcept C2779177272 @default.
• W2099331835 hasConcept C2780051608 @default.
• W2099331835 hasConcept C2780733359 @default.
• W2099331835 hasConcept C2780798758 @default.
• W2099331835 hasConcept C558461103 @default.
• W2099331835 hasConcept C71924100 @default.
• W2099331835 hasConcept C98274493 @default.
• W2099331835 hasConceptScore W2099331835C118552586 @default.
• W2099331835 hasConceptScore W2099331835C126322002 @default.
• W2099331835 hasConceptScore W2099331835C168563851 @default.
• W2099331835 hasConceptScore W2099331835C197934379 @default.
• W2099331835 hasConceptScore W2099331835C2776466888 @default.

• next