FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099334479> ?p ?o ?g. }

• W2099334479 endingPage "1934" @default.
• W2099334479 startingPage "1928" @default.
• W2099334479 abstract "Abstract Purpose: To determine the maximum-tolerated dose, toxicity profile, and pharmacokinetics of a fixed dose of paclitaxel followed by increasing doses of carboplatin, given weekly to patients with advanced esophageal or gastric junction cancer. Experimental Design: Paclitaxel was administered on day 1 as a 1-h infusion at a fixed dose of 100 mg/m2 followed by a 1-h infusion of carboplatin targeting an area under the curve (AUC) of 2–5 mg × min/ml, with cycles repeated on days 8, 15, 29, 36, and 43. Results: Forty patients [36 males; median (range) age, 57 (40–74) years] were enrolled. Dose-limiting toxicity was observed at a carboplatin AUC of 5 mg × min/ml and consisted of treatment delay attributable to myelosuppression. No grade 3/4 treatment-related nonhematological toxicity was observed. The highest dose intensity (&gt;95% of the planned dose over time) was achieved with a carboplatin AUC of 4 mg × min/ml. The mean (±SD) AUCs of unbound (Cu) and total paclitaxel were 0.662 ± 0.186 and 7.37 ± 1.33 μm × h, respectively. Clearance of Cu was 188 ± 44.6 liter/h/m2, which is not significantly different from historical data (P = 0.52). Cremophor EL clearance was 123 ± 23 ml/h/m2, similar to previous findings. Of 37 patients evaluable for response, 1 had complete response, 19 had partial response, and 10 had stable disease, accounting for an overall response rate of 54%. Conclusions: This regimen is very tolerable and effective, and the recommended doses for additional studies are paclitaxel (100 mg/m2), with carboplatin targeting an AUC of 4 mg × min/ml." @default.
• W2099334479 created "2016-06-24" @default.
• W2099334479 creator A5010810138 @default.
• W2099334479 creator A5011819733 @default.
• W2099334479 creator A5037696756 @default.
• W2099334479 creator A5050803774 @default.
• W2099334479 creator A5065279964 @default.
• W2099334479 creator A5068302495 @default.
• W2099334479 creator A5074784071 @default.
• W2099334479 creator A5086888617 @default.
• W2099334479 date "2004-03-15" @default.
• W2099334479 modified "2023-10-10" @default.
• W2099334479 title "A Phase I and Pharmacokinetic Study of Weekly Paclitaxel and Carboplatin in Patients with Metastatic Esophageal Cancer" @default.
• W2099334479 cites W1831311262 @default.
• W2099334479 cites W1839380746 @default.
• W2099334479 cites W1843791750 @default.
• W2099334479 cites W1848862702 @default.
• W2099334479 cites W1920900131 @default.
• W2099334479 cites W1946759281 @default.
• W2099334479 cites W1946819517 @default.
• W2099334479 cites W1947624718 @default.
• W2099334479 cites W1964010321 @default.
• W2099334479 cites W1976791784 @default.
• W2099334479 cites W1983192532 @default.
• W2099334479 cites W1998489771 @default.
• W2099334479 cites W2000437985 @default.
• W2099334479 cites W2007367046 @default.
• W2099334479 cites W2010070428 @default.
• W2099334479 cites W2011662336 @default.
• W2099334479 cites W2027298808 @default.
• W2099334479 cites W2034009362 @default.
• W2099334479 cites W2075743108 @default.
• W2099334479 cites W2080673255 @default.
• W2099334479 cites W2094748575 @default.
• W2099334479 cites W2101283263 @default.
• W2099334479 cites W2116996913 @default.
• W2099334479 cites W2122049931 @default.
• W2099334479 cites W2122352172 @default.
• W2099334479 cites W2172032259 @default.
• W2099334479 cites W2182396377 @default.
• W2099334479 cites W2223406810 @default.
• W2099334479 cites W2314540303 @default.
• W2099334479 cites W4237418050 @default.
• W2099334479 doi "https://doi.org/10.1158/1078-0432.ccr-03-0319" @default.
• W2099334479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15041708" @default.
• W2099334479 hasPublicationYear "2004" @default.
• W2099334479 type Work @default.
• W2099334479 sameAs 2099334479 @default.
• W2099334479 citedByCount "32" @default.
• W2099334479 countsByYear W20993344792013 @default.
• W2099334479 countsByYear W20993344792014 @default.
• W2099334479 countsByYear W20993344792015 @default.
• W2099334479 countsByYear W20993344792016 @default.
• W2099334479 countsByYear W20993344792018 @default.
• W2099334479 countsByYear W20993344792019 @default.
• W2099334479 countsByYear W20993344792020 @default.
• W2099334479 countsByYear W20993344792021 @default.
• W2099334479 countsByYear W20993344792023 @default.
• W2099334479 crossrefType "journal-article" @default.
• W2099334479 hasAuthorship W2099334479A5010810138 @default.
• W2099334479 hasAuthorship W2099334479A5011819733 @default.
• W2099334479 hasAuthorship W2099334479A5037696756 @default.
• W2099334479 hasAuthorship W2099334479A5050803774 @default.
• W2099334479 hasAuthorship W2099334479A5065279964 @default.
• W2099334479 hasAuthorship W2099334479A5068302495 @default.
• W2099334479 hasAuthorship W2099334479A5074784071 @default.
• W2099334479 hasAuthorship W2099334479A5086888617 @default.
• W2099334479 hasBestOaLocation W20993344791 @default.
• W2099334479 hasConcept C112705442 @default.
• W2099334479 hasConcept C126322002 @default.
• W2099334479 hasConcept C126894567 @default.
• W2099334479 hasConcept C2776694085 @default.
• W2099334479 hasConcept C2777292972 @default.
• W2099334479 hasConcept C2778239845 @default.
• W2099334479 hasConcept C2781413609 @default.
• W2099334479 hasConcept C2781451048 @default.
• W2099334479 hasConcept C29730261 @default.
• W2099334479 hasConcept C31760486 @default.
• W2099334479 hasConcept C71924100 @default.
• W2099334479 hasConcept C76318530 @default.
• W2099334479 hasConcept C90924648 @default.
• W2099334479 hasConceptScore W2099334479C112705442 @default.
• W2099334479 hasConceptScore W2099334479C126322002 @default.
• W2099334479 hasConceptScore W2099334479C126894567 @default.
• W2099334479 hasConceptScore W2099334479C2776694085 @default.
• W2099334479 hasConceptScore W2099334479C2777292972 @default.
• W2099334479 hasConceptScore W2099334479C2778239845 @default.
• W2099334479 hasConceptScore W2099334479C2781413609 @default.
• W2099334479 hasConceptScore W2099334479C2781451048 @default.
• W2099334479 hasConceptScore W2099334479C29730261 @default.
• W2099334479 hasConceptScore W2099334479C31760486 @default.
• W2099334479 hasConceptScore W2099334479C71924100 @default.
• W2099334479 hasConceptScore W2099334479C76318530 @default.
• W2099334479 hasConceptScore W2099334479C90924648 @default.
• W2099334479 hasIssue "6" @default.
• W2099334479 hasLocation W20993344791 @default.
• W2099334479 hasLocation W20993344792 @default.
• W2099334479 hasLocation W20993344793 @default.

• next