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- W2099339984 abstract "Atrial fibrillation (AF) is a cardiac arrhythmia that results in a rapid and irregular activation of the atrial myocardium. In humans, activation rates during AF can be as high as 400–600 pulses per minute. 1 Nattel S. New ideas about atrial fibrillation 50 years on. Nature. 2002; 415: 219-226 Crossref PubMed Scopus (1213) Google Scholar About 2–5 million people in the United States are afflicted by AF, and the incidence of the arrhythmia increases with age, affecting ∼10% of the octogenarian population. 1 Nattel S. New ideas about atrial fibrillation 50 years on. Nature. 2002; 415: 219-226 Crossref PubMed Scopus (1213) Google Scholar , 2 Chen S.A. Hsieh M.H. Tai C.T. et al. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation. 1999; 100: 1879-1886 Crossref PubMed Scopus (1358) Google Scholar AF is the number one cause of hospitalization for arrhythmias, and its incidence is predicted to double in two decades. 3 Nattel S. Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?. Cardiovasc Res. 2002; 54: 347-360 Crossref PubMed Scopus (90) Google Scholar Yet the therapeutic management for AF is challenging; antiarrhythmic drug therapies are partially effective, some of which are proarrhythmic. Thus, AF is a major challenge in cardiac electrophysiology, and a large percentage of AF patients await novel therapies for the treatment of the arrhythmia. Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilationHeart RhythmVol. 8Issue 3PreviewAcute atrial dilation increases the susceptibility to atrial fibrillation (AF). However, the mechanisms by which atrial stretch may contribute to the initiation and perpetuation of AF remain to be determined. Full-Text PDF" @default.
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- W2099339984 date "2011-03-01" @default.
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- W2099339984 title "Activation of Isac promotes atrial fibrillation initiation and perpetuation: is this a stretch?" @default.
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- W2099339984 doi "https://doi.org/10.1016/j.hrthm.2010.12.020" @default.
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