FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099349590> ?p ?o ?g. }

• W2099349590 endingPage "H1066" @default.
• W2099349590 startingPage "H1056" @default.
• W2099349590 abstract "To assess the hypothesis that gap junctions (GJs) participate on leukocyte-endothelium interactions in the inflammatory response, we compared leukocyte adhesion and transmigration elicited by cytokine stimulation in the presence or absence of GJ blockers in the hamster cheek pouch and also in the cremaster muscle of wild-type (WT) and endothelium-specific connexin 43 (Cx43) null mice (Cx43e(-/-)). In the cheek pouch, topical tumor necrosis factor-alpha (TNF-alpha; 150 ng/ml, 15 min) caused a sustained increment in the number of leukocytes adhered to venular endothelium (LAV) and located at perivenular regions (LPV). Superfusion with the GJ blockers 18-alpha-glycyrrhetinic acid (AGA; 75 microM) or 18-beta-glycyrrhetinic acid (50 microM) abolished the TNF-alpha-induced increase in LAV and LPV; carbenoxolone (75 microM) or oleamide (100 microM) reduced LAV by 50 and 75%, respectively, and LPV to a lesser extent. None of these GJ blockers modified venular diameter, blood flow, or leukocyte rolling. In contrast, glycyrrhizin (75 microM), a non-GJ blocker analog of AGA, was devoid of effect. Interestingly, when AGA was removed 90 min after TNF-alpha stimulation, LAV started to rise at a similar rate as in control. Conversely, application of AGA 90 min after TNF-alpha reduced the number of previously adhered cells. In WT mice, intrascrotal injection of TNF-alpha (0.5 microg/0.3 ml) increased LAV (fourfold) and LPV (threefold) compared with saline-injected controls. In contrast to the observations in WT animals, TNF-alpha stimulation did not increase LAV or LPV in Cx43e(-/-) mice. These results demonstrate an important role for GJ communication in leukocyte adhesion and transmigration during acute inflammation in vivo and further suggest that endothelial Cx43 is key in these processes." @default.
• W2099349590 created "2016-06-24" @default.
• W2099349590 creator A5006939155 @default.
• W2099349590 creator A5009773603 @default.
• W2099349590 creator A5035827100 @default.
• W2099349590 creator A5048172219 @default.
• W2099349590 creator A5063236840 @default.
• W2099349590 date "2008-09-01" @default.
• W2099349590 modified "2023-10-18" @default.
• W2099349590 title "Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo" @default.
• W2099349590 cites W1480224469 @default.
• W2099349590 cites W1594840853 @default.
• W2099349590 cites W188099180 @default.
• W2099349590 cites W1951903104 @default.
• W2099349590 cites W1964613075 @default.
• W2099349590 cites W1965834069 @default.
• W2099349590 cites W1969841262 @default.
• W2099349590 cites W1971126975 @default.
• W2099349590 cites W1975272337 @default.
• W2099349590 cites W1978901091 @default.
• W2099349590 cites W1994803846 @default.
• W2099349590 cites W1999978883 @default.
• W2099349590 cites W2005234088 @default.
• W2099349590 cites W2019534872 @default.
• W2099349590 cites W2022273251 @default.
• W2099349590 cites W2034521763 @default.
• W2099349590 cites W2035012227 @default.
• W2099349590 cites W2041310039 @default.
• W2099349590 cites W2052286881 @default.
• W2099349590 cites W2058740279 @default.
• W2099349590 cites W2060563738 @default.
• W2099349590 cites W2076046109 @default.
• W2099349590 cites W2080244520 @default.
• W2099349590 cites W2083313042 @default.
• W2099349590 cites W2087917186 @default.
• W2099349590 cites W2089168958 @default.
• W2099349590 cites W2093687979 @default.
• W2099349590 cites W2108739220 @default.
• W2099349590 cites W2111555798 @default.
• W2099349590 cites W2120249750 @default.
• W2099349590 cites W2123983977 @default.
• W2099349590 cites W2129522937 @default.
• W2099349590 cites W2135207317 @default.
• W2099349590 cites W2137141750 @default.
• W2099349590 cites W2138492071 @default.
• W2099349590 cites W2139998550 @default.
• W2099349590 cites W2167425930 @default.
• W2099349590 cites W2170289247 @default.
• W2099349590 cites W2181671393 @default.
• W2099349590 cites W2185776949 @default.
• W2099349590 cites W2262029677 @default.
• W2099349590 cites W2417258083 @default.
• W2099349590 doi "https://doi.org/10.1152/ajpheart.00266.2008" @default.
• W2099349590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2544495" @default.
• W2099349590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599597" @default.
• W2099349590 hasPublicationYear "2008" @default.
• W2099349590 type Work @default.
• W2099349590 sameAs 2099349590 @default.
• W2099349590 citedByCount "43" @default.
• W2099349590 countsByYear W20993495902012 @default.
• W2099349590 countsByYear W20993495902013 @default.
• W2099349590 countsByYear W20993495902014 @default.
• W2099349590 countsByYear W20993495902015 @default.
• W2099349590 countsByYear W20993495902016 @default.
• W2099349590 countsByYear W20993495902017 @default.
• W2099349590 countsByYear W20993495902018 @default.
• W2099349590 countsByYear W20993495902019 @default.
• W2099349590 countsByYear W20993495902020 @default.
• W2099349590 countsByYear W20993495902021 @default.
• W2099349590 countsByYear W20993495902022 @default.
• W2099349590 countsByYear W20993495902023 @default.
• W2099349590 crossrefType "journal-article" @default.
• W2099349590 hasAuthorship W2099349590A5006939155 @default.
• W2099349590 hasAuthorship W2099349590A5009773603 @default.
• W2099349590 hasAuthorship W2099349590A5035827100 @default.
• W2099349590 hasAuthorship W2099349590A5048172219 @default.
• W2099349590 hasAuthorship W2099349590A5063236840 @default.
• W2099349590 hasBestOaLocation W20993495902 @default.
• W2099349590 hasConcept C126322002 @default.
• W2099349590 hasConcept C134018914 @default.
• W2099349590 hasConcept C150903083 @default.
• W2099349590 hasConcept C17991360 @default.
• W2099349590 hasConcept C185592680 @default.
• W2099349590 hasConcept C203014093 @default.
• W2099349590 hasConcept C207001950 @default.
• W2099349590 hasConcept C24998067 @default.
• W2099349590 hasConcept C2776992346 @default.
• W2099349590 hasConcept C2778575167 @default.
• W2099349590 hasConcept C2778690821 @default.
• W2099349590 hasConcept C34439696 @default.
• W2099349590 hasConcept C71924100 @default.
• W2099349590 hasConcept C86803240 @default.
• W2099349590 hasConcept C98274493 @default.
• W2099349590 hasConceptScore W2099349590C126322002 @default.
• W2099349590 hasConceptScore W2099349590C134018914 @default.
• W2099349590 hasConceptScore W2099349590C150903083 @default.
• W2099349590 hasConceptScore W2099349590C17991360 @default.
• W2099349590 hasConceptScore W2099349590C185592680 @default.

• next