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• W2099350622 abstract "Helicobacter pylori is a gastric pathogen responsible for a high disease burden worldwide. Deregulated inflammatory responses, possibly involving macrophages, are implicated in H . pylori -induced pathology, and microRNAs, such as miR-155, have recently emerged as crucial regulators of innate immunity and inflammatory responses. miR-155 is regulated by Toll-like receptor (TLR) ligands in monocyte-derived cells and has been shown to be induced in macrophages during H . pylori infection. Here, we investigated the regulation of miR-155 expression in primary murine bone marrow-derived macrophages (BMMs) during H . pylori infection and examined the downstream mRNA targets of this microRNA using microarray analysis. We report TLR2/4- and NOD1/2-independent up-regulation of miR-155, which was found to be dependent on the major H . pylori pathogenicity determinant, the type IV secretion system (T4SS). miR-155 expression was dependent on NF-κB signaling but was independent of CagA. Microarray analysis identified known gene targets of miR-155 in BMMs during H . pylori infection that are proapoptotic. We also identified and validated miR-155 binding sites in the 3′ UTRs of the targets, Tspan14 , Lpin1 , and Pmaip1 . We observed that H . pylori -infected miR-155 −/− BMMs were significantly more susceptible to cisplatin DNA damage-induced apoptosis than were wild-type BMMs. Thus, our data suggest a function for the prototypical H . pylori pathogenicity factor, the T4SS, in the up-regulation of miR-155 in BMMs. We propose the antiapoptotic effects of miR-155 could enhance macrophage resistance to apoptosis induced by DNA damage during H . pylori infection." @default.
• W2099350622 created "2016-06-24" @default.
• W2099350622 creator A5024513852 @default.
• W2099350622 creator A5031782465 @default.
• W2099350622 creator A5067941504 @default.
• W2099350622 creator A5079499882 @default.
• W2099350622 date "2012-04-16" @default.
• W2099350622 modified "2023-10-14" @default.
• W2099350622 title "Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis" @default.
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• W2099350622 doi "https://doi.org/10.1073/pnas.1116125109" @default.
• W2099350622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3358876" @default.
• W2099350622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22509021" @default.
• W2099350622 hasPublicationYear "2012" @default.
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