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• W2099355613 abstract "Stable RNAs must form specific three-dimensional structures, yet many RNAs become kinetically trapped in misfolded conformations. To understand the factors that control the accuracy of RNA folding in the cell, the self-splicing activity of the Tetrahymena group I intron was compared in different genetic contexts in budding yeast. The extent of splicing was 98% when the intron was placed in its natural rDNA context, but only 3% when the intron was expressed in an exogenous pre-mRNA. Further experiments showed that the probability of forming the active intron structure depends on local sequence context and transcription by Pol I. Pre-rRNAs decayed at similar rates, whether the intron was wild type or inactivated by an internal deletion, suggesting that most of the unreacted pre-rRNA is incompetent to splice. Northern blots and complementation assays showed that mutations that destabilize the intron tertiary structure inhibited self-splicing and processing of internal transcribed spacer 2. The data are consistent with partitioning of pre-rRNAs into active and inactive populations. The misfolded RNAs are sequestered and degraded without refolding to a significant extent. Thus, the initial fidelity of folding can dictate the intracellular fate of transcripts containing this group I intron." @default.
• W2099355613 created "2016-06-24" @default.
• W2099355613 creator A5013819044 @default.
• W2099355613 creator A5062535756 @default.
• W2099355613 creator A5078281937 @default.
• W2099355613 date "2006-10-24" @default.
• W2099355613 modified "2023-09-27" @default.
• W2099355613 title "Self-splicing of a group I intron reveals partitioning of native and misfolded RNA populations in yeast" @default.
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• W2099355613 doi "https://doi.org/10.1261/rna.184206" @default.
• W2099355613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1664722" @default.
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