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- W2099355940 endingPage "117" @default.
- W2099355940 startingPage "109" @default.
- W2099355940 abstract "Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New blood vessel formation is crucial during both primary bone development as well as fracture repair in adults. Both bone repair and bone remodeling involve the activation and complex interaction between angiogenic and osteogenic pathways. Interestingly studies have demonstrated that angiogenesis precedes the onset of osteogenesis. Indeed reduced or inadequate blood flow has been linked to impaired fracture healing and old age related low bone mass disorders such as osteoporosis. Similarly the slow penetration of host blood vessels in large engineered bone tissue grafts has been cited as one of the major hurdle still impeding current bone construction engineering strategies. This article reviews the current knowledge elaborating the importance of vascularization during bone healing and remodeling, and the current therapeutic strategies being adapted to promote and improve angiogenesis." @default.
- W2099355940 created "2016-06-24" @default.
- W2099355940 creator A5005176596 @default.
- W2099355940 creator A5049564325 @default.
- W2099355940 creator A5057490217 @default.
- W2099355940 date "2014-11-01" @default.
- W2099355940 modified "2023-10-17" @default.
- W2099355940 title "Role of angiogenesis in bone repair" @default.
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