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- W2099380079 abstract "textabstractEncased within the bones of the body, there exists an organ system, the bonemarrow, in which a large number of different cell types develops. Most bonemarrow (BM) cells belong to the hemopoietic and lymphatic lineages (i.e.erythrocytes, platelets, granulocytes, macrophages and lymphocytes). Other celltypes have also been shown to be derived from precursor cells that are presentin the BM: tissue mast cells (Kitamura et al., 1977 and 1981), dendritic cells(Steinman et al., 1974; Pugh et al, 1983), Kupffer cells (van Furth, 1980;Bouwens and Wisse, 1980) and osteoclasts (Ash et al, 1980). The bone marrow isthus a source of cells which have a wide variety of functions and which can befound in many tissues of the body. Most BM cells are mature cells. Althoughthe mature cells are important for the homeostasis of the body, they will not beconsidered in this thesis.Many experiments have been and still are performed with the intention tocharacterize and isolate the cell(s) that give rise to the above mentionedmature cell types. The concept of a pluripotent hemopoietic stem cell {PHSC)has arisen from these experiments. It has been hypothesized that the PHSC,after the proper stimulation, can give rise to all BM derived cell types.Another important characteristic of the PHSC is its capacity for self renewal.This will be discussed below.Other experiments have pointed to the existence of cells in the BM that haveonly a limited capacity for differentiating and self renewal potential whencompared to the PHSC. These restricted stem cells can only give rise todescendants in one or two closely related differentiation pathways. These stemcells are often referred to as progenitor cells or committed precursor cells andas uni(or bi)potent hemopoietic stem cells. This stem cell type receives littleattention in this thesis." @default.
- W2099380079 created "2016-06-24" @default.
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- W2099380079 date "1986-09-10" @default.
- W2099380079 modified "2023-09-23" @default.
- W2099380079 title "Differentiation of hemopoietic stem cells in the thymus" @default.
- W2099380079 hasPublicationYear "1986" @default.
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