Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099382906> ?p ?o ?g. }
- W2099382906 endingPage "1915" @default.
- W2099382906 startingPage "1908" @default.
- W2099382906 abstract "Excessive dietary intake of carbohydrates and fats has been linked to the development of obesity. However, the mechanism by which these dietary factors interact to bring about metabolic changes has not been elucidated. We examined the combined effects of different types of dietary carbohydrates and fats on the etiology of obesity and its complications in the Zucker fatty (fa/fa) rat, a model of obesity. Specifically, these rats were fed an isocaloric diet containing various combinations of carbohydrates [palatinose (P), an insulin-sparing sucrose analogue, and sucrose (S)] and fatty acids [oleic acid (O) and linoleic acid (L)]. After 8 wk, palatinose feeding (PO and PL) led to significant reductions in visceral fat mass, adipocyte cell size, hyperglycemia, and hyperlipidemia compared with sucrose feeding (SO and SL); pancreatic islet hypertrophy was also prevented by palatinose feeding. Linoleic-acid-fed rats (PL and SL) exhibited reduced insulin-immunoreactive staining of the pancreatic islets, enhanced macrophage infiltration in adipose tissue, and an elevated plasma tumor necrosis factor-alpha concentration when compared with oleic-acid-fed rats (PO and SO). Furthermore, sucrose and linoleic acid synergistically increased the expression of genes involved in hepatic gluconeogenesis and lipogenesis [sterol regulatory-element binding protein (SREBP)-1c and SREBP-2]. In conclusion, a diet containing palatinose and oleic acid may prevent diet-induced metabolic abnormalities. The combination of palatinose and oleic acid holds promise for a new approach to preventing and treating obesity and its complications." @default.
- W2099382906 created "2016-06-24" @default.
- W2099382906 creator A5007789093 @default.
- W2099382906 creator A5020065888 @default.
- W2099382906 creator A5047877300 @default.
- W2099382906 creator A5055461853 @default.
- W2099382906 creator A5056217295 @default.
- W2099382906 creator A5064554088 @default.
- W2099382906 creator A5066544844 @default.
- W2099382906 creator A5068286366 @default.
- W2099382906 creator A5069467740 @default.
- W2099382906 creator A5089275347 @default.
- W2099382906 creator A5090554854 @default.
- W2099382906 date "2007-08-01" @default.
- W2099382906 modified "2023-10-14" @default.
- W2099382906 title "Dietary Palatinose and Oleic Acid Ameliorate Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats , ,3" @default.
- W2099382906 cites W1500096867 @default.
- W2099382906 cites W1529323684 @default.
- W2099382906 cites W1534360145 @default.
- W2099382906 cites W1768540043 @default.
- W2099382906 cites W1918244654 @default.
- W2099382906 cites W1933010308 @default.
- W2099382906 cites W1938254948 @default.
- W2099382906 cites W1968631573 @default.
- W2099382906 cites W1975299615 @default.
- W2099382906 cites W1975962309 @default.
- W2099382906 cites W1983143451 @default.
- W2099382906 cites W1987031993 @default.
- W2099382906 cites W1991401793 @default.
- W2099382906 cites W2004812742 @default.
- W2099382906 cites W2005530469 @default.
- W2099382906 cites W2007096428 @default.
- W2099382906 cites W2007972080 @default.
- W2099382906 cites W2018636748 @default.
- W2099382906 cites W2029115838 @default.
- W2099382906 cites W2036852488 @default.
- W2099382906 cites W2060070399 @default.
- W2099382906 cites W2067909508 @default.
- W2099382906 cites W2072287994 @default.
- W2099382906 cites W2077904086 @default.
- W2099382906 cites W2081991528 @default.
- W2099382906 cites W2099903211 @default.
- W2099382906 cites W2100737381 @default.
- W2099382906 cites W2103116278 @default.
- W2099382906 cites W2103206138 @default.
- W2099382906 cites W2110963123 @default.
- W2099382906 cites W2111601150 @default.
- W2099382906 cites W2111739792 @default.
- W2099382906 cites W2112097932 @default.
- W2099382906 cites W2114472618 @default.
- W2099382906 cites W2117537998 @default.
- W2099382906 cites W2128473384 @default.
- W2099382906 cites W2129213331 @default.
- W2099382906 cites W2132981882 @default.
- W2099382906 cites W2135433897 @default.
- W2099382906 cites W2136928072 @default.
- W2099382906 cites W2147597228 @default.
- W2099382906 cites W2153540284 @default.
- W2099382906 cites W2168526937 @default.
- W2099382906 cites W2175933285 @default.
- W2099382906 cites W2340325420 @default.
- W2099382906 cites W3023533824 @default.
- W2099382906 cites W4238497443 @default.
- W2099382906 cites W4249727000 @default.
- W2099382906 doi "https://doi.org/10.1093/jn/137.8.1908" @default.
- W2099382906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17634263" @default.
- W2099382906 hasPublicationYear "2007" @default.
- W2099382906 type Work @default.
- W2099382906 sameAs 2099382906 @default.
- W2099382906 citedByCount "48" @default.
- W2099382906 countsByYear W20993829062012 @default.
- W2099382906 countsByYear W20993829062014 @default.
- W2099382906 countsByYear W20993829062015 @default.
- W2099382906 countsByYear W20993829062016 @default.
- W2099382906 countsByYear W20993829062017 @default.
- W2099382906 countsByYear W20993829062018 @default.
- W2099382906 countsByYear W20993829062020 @default.
- W2099382906 countsByYear W20993829062021 @default.
- W2099382906 countsByYear W20993829062023 @default.
- W2099382906 crossrefType "journal-article" @default.
- W2099382906 hasAuthorship W2099382906A5007789093 @default.
- W2099382906 hasAuthorship W2099382906A5020065888 @default.
- W2099382906 hasAuthorship W2099382906A5047877300 @default.
- W2099382906 hasAuthorship W2099382906A5055461853 @default.
- W2099382906 hasAuthorship W2099382906A5056217295 @default.
- W2099382906 hasAuthorship W2099382906A5064554088 @default.
- W2099382906 hasAuthorship W2099382906A5066544844 @default.
- W2099382906 hasAuthorship W2099382906A5068286366 @default.
- W2099382906 hasAuthorship W2099382906A5069467740 @default.
- W2099382906 hasAuthorship W2099382906A5089275347 @default.
- W2099382906 hasAuthorship W2099382906A5090554854 @default.
- W2099382906 hasBestOaLocation W20993829061 @default.
- W2099382906 hasConcept C126322002 @default.
- W2099382906 hasConcept C134018914 @default.
- W2099382906 hasConcept C141359234 @default.
- W2099382906 hasConcept C171089720 @default.
- W2099382906 hasConcept C185592680 @default.
- W2099382906 hasConcept C2779306644 @default.