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• W2099386776 startingPage "4374" @default.
• W2099386776 abstract "In the past few years, many studies have attempted to measure the strength of a single molecular bond. In general, these experiments consisted in pulling on the bond and measuring the force necessary to dissociate the molecules. However, seemingly contradictory experimental results led to draw the intriguing conclusion that the strength of the bond could depend on the experiment even if the pulling conditions are similar: this paradox was first observed on the widely used streptavidin-biotin bond. Here, by doing supplementary measurements and by reanalyzing the controversial experimental results using Kramers' theory, we show that they can be conciliated. This allows us to show that the strength of a bond is very sensitive to the history of its formation, which is the key to the paradox." @default.
• W2099386776 created "2016-06-24" @default.
• W2099386776 creator A5020176772 @default.
• W2099386776 creator A5045553702 @default.
• W2099386776 date "2005-12-01" @default.
• W2099386776 modified "2023-10-15" @default.
• W2099386776 title "The Solution to the Streptavidin-Biotin Paradox: The Influence of History on the Strength of Single Molecular Bonds" @default.
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• W2099386776 doi "https://doi.org/10.1529/biophysj.105.067769" @default.
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