Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099396593> ?p ?o ?g. }
- W2099396593 endingPage "6848" @default.
- W2099396593 startingPage "6840" @default.
- W2099396593 abstract "Abstract The requirements for B7 costimulation during an in vivo humoral response to an intact extracellular bacteria have not been reported. In this study we immunized mice with Streptococcus pneumoniae (R36A) to determine the B7 requirements for induction of Ig, specific for two determinants on R36A, the phosphorylcholine (PC) determinant of C-polysaccharide and pneumococcal surface protein A (PspA). We show that the primary anti-PspA response, the development of PspA-specific memory, and the induction of the secondary anti-PspA response in primed mice were completely dependent upon B7 costimulation. Of note, costimulation was required only briefly after the secondary immunization compared with after the primary immunization for optimal induction of Ig. Blockade of B7 costimulation at the time of secondary immunization also completely abrogated the established state of memory, but did not induce tolerance. In contrast to the anti-PspA response, the primary anti-PC response involved only a very short period of B7 costimulation. Whereas B7-2 alone was required for induction of the primary anti-PspA and anti-PC responses, a redundant role for B7-1 and B7-2 was noted for the PspA-specific secondary response. CTLA4Ig blocked both the anti-PC and anti-PspA responses equally well over a wide range of bacterial doses. These studies demonstrate a critical, but variable, role for B7-dependent costimulation during an Ig response to an extracellular bacteria." @default.
- W2099396593 created "2016-06-24" @default.
- W2099396593 creator A5005922624 @default.
- W2099396593 creator A5010740129 @default.
- W2099396593 creator A5011615487 @default.
- W2099396593 creator A5015484712 @default.
- W2099396593 creator A5037984313 @default.
- W2099396593 creator A5046741238 @default.
- W2099396593 creator A5060192865 @default.
- W2099396593 creator A5063304740 @default.
- W2099396593 creator A5067957698 @default.
- W2099396593 date "2000-12-15" @default.
- W2099396593 modified "2023-09-23" @default.
- W2099396593 title "B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to<i>Streptococcus pneumoniae</i>" @default.
- W2099396593 cites W1485596855 @default.
- W2099396593 cites W1488500980 @default.
- W2099396593 cites W1497963394 @default.
- W2099396593 cites W1514247226 @default.
- W2099396593 cites W1524214352 @default.
- W2099396593 cites W1527802692 @default.
- W2099396593 cites W1570594698 @default.
- W2099396593 cites W1599080309 @default.
- W2099396593 cites W1621209507 @default.
- W2099396593 cites W1647115901 @default.
- W2099396593 cites W1658073345 @default.
- W2099396593 cites W1678411211 @default.
- W2099396593 cites W1826859465 @default.
- W2099396593 cites W1911500455 @default.
- W2099396593 cites W1945298789 @default.
- W2099396593 cites W1969466880 @default.
- W2099396593 cites W1974381902 @default.
- W2099396593 cites W1979674588 @default.
- W2099396593 cites W1981699748 @default.
- W2099396593 cites W1982878221 @default.
- W2099396593 cites W1983626365 @default.
- W2099396593 cites W1983824988 @default.
- W2099396593 cites W1988422289 @default.
- W2099396593 cites W1991531286 @default.
- W2099396593 cites W2006256724 @default.
- W2099396593 cites W2012912776 @default.
- W2099396593 cites W2017080462 @default.
- W2099396593 cites W2019291297 @default.
- W2099396593 cites W2023406155 @default.
- W2099396593 cites W2029865350 @default.
- W2099396593 cites W2037374883 @default.
- W2099396593 cites W2044163622 @default.
- W2099396593 cites W2045654426 @default.
- W2099396593 cites W2048172864 @default.
- W2099396593 cites W2056616704 @default.
- W2099396593 cites W2057809738 @default.
- W2099396593 cites W2062029576 @default.
- W2099396593 cites W2062058886 @default.
- W2099396593 cites W2073204838 @default.
- W2099396593 cites W2073352481 @default.
- W2099396593 cites W2074220343 @default.
- W2099396593 cites W2075453847 @default.
- W2099396593 cites W2077334888 @default.
- W2099396593 cites W2077389439 @default.
- W2099396593 cites W2088237595 @default.
- W2099396593 cites W2090481553 @default.
- W2099396593 cites W2092233067 @default.
- W2099396593 cites W2095808278 @default.
- W2099396593 cites W2105678831 @default.
- W2099396593 cites W2122153462 @default.
- W2099396593 cites W2122520351 @default.
- W2099396593 cites W2123856608 @default.
- W2099396593 cites W2129844449 @default.
- W2099396593 cites W2133619856 @default.
- W2099396593 cites W2138067578 @default.
- W2099396593 cites W2139208419 @default.
- W2099396593 cites W2141666769 @default.
- W2099396593 cites W2145473252 @default.
- W2099396593 cites W2146907765 @default.
- W2099396593 cites W2150343901 @default.
- W2099396593 cites W2154753397 @default.
- W2099396593 cites W2162856391 @default.
- W2099396593 cites W2214620900 @default.
- W2099396593 cites W4313377153 @default.
- W2099396593 doi "https://doi.org/10.4049/jimmunol.165.12.6840" @default.
- W2099396593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11120807" @default.
- W2099396593 hasPublicationYear "2000" @default.
- W2099396593 type Work @default.
- W2099396593 sameAs 2099396593 @default.
- W2099396593 citedByCount "44" @default.
- W2099396593 countsByYear W20993965932012 @default.
- W2099396593 countsByYear W20993965932013 @default.
- W2099396593 countsByYear W20993965932014 @default.
- W2099396593 countsByYear W20993965932015 @default.
- W2099396593 countsByYear W20993965932018 @default.
- W2099396593 countsByYear W20993965932019 @default.
- W2099396593 countsByYear W20993965932021 @default.
- W2099396593 crossrefType "journal-article" @default.
- W2099396593 hasAuthorship W2099396593A5005922624 @default.
- W2099396593 hasAuthorship W2099396593A5010740129 @default.
- W2099396593 hasAuthorship W2099396593A5011615487 @default.
- W2099396593 hasAuthorship W2099396593A5015484712 @default.
- W2099396593 hasAuthorship W2099396593A5037984313 @default.
- W2099396593 hasAuthorship W2099396593A5046741238 @default.