Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099416170> ?p ?o ?g. }
- W2099416170 endingPage "484" @default.
- W2099416170 startingPage "475" @default.
- W2099416170 abstract "There is a history dependence of skeletal muscle contraction: stretching activated muscles induces a long-lasting force enhancement, while shortening activated muscles induces a long-lasting force depression. These history-dependent properties cannot be explained by the current model of muscle contraction, and its mechanism is unknown. The purposes of this study were (i) to evaluate if force enhancement and force depression are present at short lengths (the ascending limb of the force-length (FL) relationship), (ii) to evaluate if the history-dependent properties are associated with sarcomere length (SL) non-uniformity and (iii) to determine the effects of cross-bridge (de)activation on force depression. Rabbit psoas myofibrils were isolated and attached between two microneedles for force measurements. Images of the myofibrils were projected onto a linear photodiode array for measurements of SL. Myofibrils were activated by either Ca(2+) or MgADP; the latter induces cross-bridge attachment to actin independently of Ca(2+). Activated myofibrils were subjected to three stretches or shortenings (approx. 4% SL at approx. 0.07 microm s(-1) sarcomere(-1)) along the ascending limb of the FL relationship separated by periods (approx. 5 s) of isometric contraction. Force after stretch was higher than force after shortening at similar SLs. The differences in force could not be explained by SL non-uniformity. The FL relationship produced by Ca(2+)- and MgADP-activated myofibrils were similar in stretch experiments, but after shortening MgADP activation produced forces that were higher than Ca(2+) activation. Since MgADP induces the formation of strongly bound cross-bridges, this result suggests that force depression following shortening is associated with cross-bridge deactivation." @default.
- W2099416170 created "2016-06-24" @default.
- W2099416170 creator A5051531603 @default.
- W2099416170 creator A5068512846 @default.
- W2099416170 creator A5082239940 @default.
- W2099416170 date "2009-10-21" @default.
- W2099416170 modified "2023-10-02" @default.
- W2099416170 title "History-dependent properties of skeletal muscle myofibrils contracting along the ascending limb of the force–length relationship" @default.
- W2099416170 cites W143481990 @default.
- W2099416170 cites W1577214112 @default.
- W2099416170 cites W1901823973 @default.
- W2099416170 cites W1963605011 @default.
- W2099416170 cites W1973557647 @default.
- W2099416170 cites W1975714515 @default.
- W2099416170 cites W1982374095 @default.
- W2099416170 cites W1989255509 @default.
- W2099416170 cites W1990542086 @default.
- W2099416170 cites W1991467446 @default.
- W2099416170 cites W1998451216 @default.
- W2099416170 cites W2001056402 @default.
- W2099416170 cites W2014383313 @default.
- W2099416170 cites W2017681545 @default.
- W2099416170 cites W2017745285 @default.
- W2099416170 cites W2020998038 @default.
- W2099416170 cites W2021616768 @default.
- W2099416170 cites W2028490275 @default.
- W2099416170 cites W2063786696 @default.
- W2099416170 cites W2066695812 @default.
- W2099416170 cites W2079341009 @default.
- W2099416170 cites W2089114409 @default.
- W2099416170 cites W2092905842 @default.
- W2099416170 cites W2095554109 @default.
- W2099416170 cites W2095806733 @default.
- W2099416170 cites W2097857897 @default.
- W2099416170 cites W2105944799 @default.
- W2099416170 cites W2134816291 @default.
- W2099416170 cites W2142557974 @default.
- W2099416170 cites W2147685289 @default.
- W2099416170 cites W2153646540 @default.
- W2099416170 cites W2153744832 @default.
- W2099416170 cites W2161183120 @default.
- W2099416170 cites W2169291811 @default.
- W2099416170 cites W2169400659 @default.
- W2099416170 cites W2170989552 @default.
- W2099416170 cites W789458867 @default.
- W2099416170 doi "https://doi.org/10.1098/rspb.2009.1579" @default.
- W2099416170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2842654" @default.
- W2099416170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19846455" @default.
- W2099416170 hasPublicationYear "2009" @default.
- W2099416170 type Work @default.
- W2099416170 sameAs 2099416170 @default.
- W2099416170 citedByCount "38" @default.
- W2099416170 countsByYear W20994161702012 @default.
- W2099416170 countsByYear W20994161702013 @default.
- W2099416170 countsByYear W20994161702014 @default.
- W2099416170 countsByYear W20994161702015 @default.
- W2099416170 countsByYear W20994161702016 @default.
- W2099416170 countsByYear W20994161702017 @default.
- W2099416170 countsByYear W20994161702018 @default.
- W2099416170 countsByYear W20994161702019 @default.
- W2099416170 countsByYear W20994161702020 @default.
- W2099416170 countsByYear W20994161702021 @default.
- W2099416170 countsByYear W20994161702022 @default.
- W2099416170 countsByYear W20994161702023 @default.
- W2099416170 crossrefType "journal-article" @default.
- W2099416170 hasAuthorship W2099416170A5051531603 @default.
- W2099416170 hasAuthorship W2099416170A5068512846 @default.
- W2099416170 hasAuthorship W2099416170A5082239940 @default.
- W2099416170 hasBestOaLocation W20994161701 @default.
- W2099416170 hasConcept C103486182 @default.
- W2099416170 hasConcept C105702510 @default.
- W2099416170 hasConcept C12554922 @default.
- W2099416170 hasConcept C134018914 @default.
- W2099416170 hasConcept C163415756 @default.
- W2099416170 hasConcept C185592680 @default.
- W2099416170 hasConcept C207200792 @default.
- W2099416170 hasConcept C2776050358 @default.
- W2099416170 hasConcept C2779959927 @default.
- W2099416170 hasConcept C42407357 @default.
- W2099416170 hasConcept C55493867 @default.
- W2099416170 hasConcept C68731436 @default.
- W2099416170 hasConcept C7301908 @default.
- W2099416170 hasConcept C86803240 @default.
- W2099416170 hasConcept C95444343 @default.
- W2099416170 hasConceptScore W2099416170C103486182 @default.
- W2099416170 hasConceptScore W2099416170C105702510 @default.
- W2099416170 hasConceptScore W2099416170C12554922 @default.
- W2099416170 hasConceptScore W2099416170C134018914 @default.
- W2099416170 hasConceptScore W2099416170C163415756 @default.
- W2099416170 hasConceptScore W2099416170C185592680 @default.
- W2099416170 hasConceptScore W2099416170C207200792 @default.
- W2099416170 hasConceptScore W2099416170C2776050358 @default.
- W2099416170 hasConceptScore W2099416170C2779959927 @default.
- W2099416170 hasConceptScore W2099416170C42407357 @default.
- W2099416170 hasConceptScore W2099416170C55493867 @default.
- W2099416170 hasConceptScore W2099416170C68731436 @default.
- W2099416170 hasConceptScore W2099416170C7301908 @default.
- W2099416170 hasConceptScore W2099416170C86803240 @default.