FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099428718> ?p ?o ?g. }

• W2099428718 endingPage "6521" @default.
• W2099428718 startingPage "6515" @default.
• W2099428718 abstract "Abstract Sorafenib is a multikinase inhibitor whose targets include B-RAF and C-RAF, both of which function in the extracellular signal-regulated kinase (ERK) signaling pathway but which also have distinct downstream targets. The relative effects of sorafenib on B-RAF and C-RAF signaling in tumor cells remain unclear, however. We have now examined the effects of sorafenib as well as of B-RAF or C-RAF depletion by RNA interference on cell growth and ERK signaling in non–small cell lung cancer (NSCLC) cell lines with or without KRAS mutations. Sorafenib inhibited ERK phosphorylation in cells with wild-type KRAS but not in those with mutant KRAS. Despite this difference, sorafenib inhibited cell growth and induced G1 arrest in both cell types. Depletion of B-RAF, but not that of C-RAF, inhibited ERK phosphorylation as well as suppressed cell growth and induced G1 arrest in cells with wild-type KRAS. In contrast, depletion of C-RAF inhibited cell growth and induced G1 arrest, without affecting ERK phosphorylation, in cells with mutant KRAS; depletion of B-RAF did not induce G1 arrest in these cells. These data suggest that B-RAF-ERK signaling and C-RAF signaling play the dominant roles in regulation of cell growth in NSCLC cells with wild-type or mutant KRAS, respectively. The G1 arrest induced by either C-RAF depletion or sorafenib in cells with mutant KRAS was associated with down-regulation of cyclin E. Our results thus suggest that sorafenib inhibits NSCLC cell growth by targeting B-RAF in cells with wild-type KRAS and C-RAF in those with mutant KRAS. [Cancer Res 2009;69(16):6515–21]" @default.
• W2099428718 created "2016-06-24" @default.
• W2099428718 creator A5000304341 @default.
• W2099428718 creator A5017396574 @default.
• W2099428718 creator A5024261346 @default.
• W2099428718 creator A5026973085 @default.
• W2099428718 creator A5040004004 @default.
• W2099428718 creator A5042374252 @default.
• W2099428718 creator A5072724155 @default.
• W2099428718 date "2009-08-12" @default.
• W2099428718 modified "2023-09-23" @default.
• W2099428718 title "Sorafenib Inhibits Non–Small Cell Lung Cancer Cell Growth by Targeting B-RAF in <i>KRAS</i> Wild-Type Cells and C-RAF in <i>KRAS</i> Mutant Cells" @default.
• W2099428718 cites W1589959819 @default.
• W2099428718 cites W1894308363 @default.
• W2099428718 cites W1965097080 @default.
• W2099428718 cites W1980534531 @default.
• W2099428718 cites W1989188414 @default.
• W2099428718 cites W1990774346 @default.
• W2099428718 cites W2013492212 @default.
• W2099428718 cites W2022426817 @default.
• W2099428718 cites W2032751670 @default.
• W2099428718 cites W2037048868 @default.
• W2099428718 cites W2041687747 @default.
• W2099428718 cites W2043103956 @default.
• W2099428718 cites W2048672579 @default.
• W2099428718 cites W2049171090 @default.
• W2099428718 cites W2061338920 @default.
• W2099428718 cites W2062657417 @default.
• W2099428718 cites W2069158176 @default.
• W2099428718 cites W2070396671 @default.
• W2099428718 cites W2100516555 @default.
• W2099428718 cites W2101024186 @default.
• W2099428718 cites W2101789374 @default.
• W2099428718 cites W2101951251 @default.
• W2099428718 cites W2109075732 @default.
• W2099428718 cites W2111888201 @default.
• W2099428718 cites W2118004874 @default.
• W2099428718 cites W2121389354 @default.
• W2099428718 cites W2127342594 @default.
• W2099428718 cites W2130673296 @default.
• W2099428718 cites W2134490812 @default.
• W2099428718 cites W2137715268 @default.
• W2099428718 cites W2140765540 @default.
• W2099428718 cites W2147415859 @default.
• W2099428718 cites W2151507583 @default.
• W2099428718 cites W2151898419 @default.
• W2099428718 cites W2154209447 @default.
• W2099428718 cites W2155381255 @default.
• W2099428718 cites W2156887503 @default.
• W2099428718 cites W2161614082 @default.
• W2099428718 cites W2229860909 @default.
• W2099428718 cites W2249182920 @default.
• W2099428718 cites W2316297264 @default.
• W2099428718 cites W2320138981 @default.
• W2099428718 cites W2337358073 @default.
• W2099428718 cites W2418447573 @default.
• W2099428718 cites W2517521286 @default.
• W2099428718 cites W2589867092 @default.
• W2099428718 doi "https://doi.org/10.1158/0008-5472.can-09-1076" @default.
• W2099428718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19638574" @default.
• W2099428718 hasPublicationYear "2009" @default.
• W2099428718 type Work @default.
• W2099428718 sameAs 2099428718 @default.
• W2099428718 citedByCount "80" @default.
• W2099428718 countsByYear W20994287182012 @default.
• W2099428718 countsByYear W20994287182013 @default.
• W2099428718 countsByYear W20994287182014 @default.
• W2099428718 countsByYear W20994287182015 @default.
• W2099428718 countsByYear W20994287182016 @default.
• W2099428718 countsByYear W20994287182017 @default.
• W2099428718 countsByYear W20994287182018 @default.
• W2099428718 countsByYear W20994287182019 @default.
• W2099428718 countsByYear W20994287182020 @default.
• W2099428718 countsByYear W20994287182021 @default.
• W2099428718 countsByYear W20994287182022 @default.
• W2099428718 countsByYear W20994287182023 @default.
• W2099428718 crossrefType "journal-article" @default.
• W2099428718 hasAuthorship W2099428718A5000304341 @default.
• W2099428718 hasAuthorship W2099428718A5017396574 @default.
• W2099428718 hasAuthorship W2099428718A5024261346 @default.
• W2099428718 hasAuthorship W2099428718A5026973085 @default.
• W2099428718 hasAuthorship W2099428718A5040004004 @default.
• W2099428718 hasAuthorship W2099428718A5042374252 @default.
• W2099428718 hasAuthorship W2099428718A5072724155 @default.
• W2099428718 hasConcept C121608353 @default.
• W2099428718 hasConcept C1491633281 @default.
• W2099428718 hasConcept C184235292 @default.
• W2099428718 hasConcept C185592680 @default.
• W2099428718 hasConcept C2778019345 @default.
• W2099428718 hasConcept C2778695046 @default.
• W2099428718 hasConcept C2781187634 @default.
• W2099428718 hasConcept C29537977 @default.
• W2099428718 hasConcept C502942594 @default.
• W2099428718 hasConcept C526805850 @default.
• W2099428718 hasConcept C54355233 @default.
• W2099428718 hasConcept C55493867 @default.
• W2099428718 hasConcept C57074206 @default.
• W2099428718 hasConcept C62112901 @default.

• next