FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099452973> ?p ?o ?g. }

• W2099452973 endingPage "314" @default.
• W2099452973 startingPage "309" @default.
• W2099452973 abstract "Abstract: Peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) agonists have been found to have potent anti‐inflammatory actions and suggested as potential therapies for brain ischaemia. Glutamate is the most common excitatory neurotransmitter in the central nervous system and is released excessively during ischaemia. Stroke therapy will require combinations of drug classes, because no single drug class has yet been proven efficacious in human beings. The present study was conducted to assess whether N‐methyl‐ d ‐aspartate (NMDA) receptor antagonist (MK‐801) treatment can improve recovery from ischaemic brain injury and whether rosiglitazone, a PPAR‐γ ligand, can increase its neuroprotective effect in an embolic model of stroke. Stroke was induced in rats by embolizing a preformed clot into the middle cerebral artery. Rosiglitazone (0.1 mg/kg, intraperitoneally) and MK‐801 (0.1 mg/kg, intravenously) were injected immediately after embolization. Forty‐eight hours later, the brains were removed, sectioned and stained with triphenyltetrazolum chloride and analysed by a commercial image processing software programme. Rosiglitazone and MK‐801 alone or in combination decreased infarct volume by 49.16%, 50.26% and 81.32%, respectively (P < 0.001). Moreover, the combination therapy significantly decreased the infarct volume when compared to any drug used alone (P < 0.05). MK‐801 reduced the brain oedema by 68% compared to the control group (P < 0.05), but rosiglitazone or combination did not show any significant effect. The drugs alone or in combination also demonstrated improved neurological function, but combination therapy was more effective on neurological deficits improving. Our data show that the combination of MK‐801 and rosiglitazone is more neuroprotective in thromboembolic stroke than given alone; this effect perhaps represents a possible additive effect in the brain infarction." @default.
• W2099452973 created "2016-06-24" @default.
• W2099452973 creator A5003435929 @default.
• W2099452973 creator A5016889206 @default.
• W2099452973 creator A5030057156 @default.
• W2099452973 creator A5059240200 @default.
• W2099452973 date "2007-08-29" @default.
• W2099452973 modified "2023-10-15" @default.
• W2099452973 title "Combination Therapy of Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-? Ligand, and NMDA Receptor Antagonist (MK-801) on Experimental Embolic Stroke in Rats" @default.
• W2099452973 cites W1965348397 @default.
• W2099452973 cites W1968462732 @default.
• W2099452973 cites W1973491513 @default.
• W2099452973 cites W1976804370 @default.
• W2099452973 cites W1978922638 @default.
• W2099452973 cites W1984699557 @default.
• W2099452973 cites W1987703942 @default.
• W2099452973 cites W1989584113 @default.
• W2099452973 cites W2008839943 @default.
• W2099452973 cites W2011455771 @default.
• W2099452973 cites W2020827630 @default.
• W2099452973 cites W2022317515 @default.
• W2099452973 cites W2023459898 @default.
• W2099452973 cites W2055113811 @default.
• W2099452973 cites W2058902596 @default.
• W2099452973 cites W2064848476 @default.
• W2099452973 cites W2066132259 @default.
• W2099452973 cites W2068568529 @default.
• W2099452973 cites W2070547475 @default.
• W2099452973 cites W2072158510 @default.
• W2099452973 cites W2078820838 @default.
• W2099452973 cites W2081092754 @default.
• W2099452973 cites W2085973940 @default.
• W2099452973 cites W2102772338 @default.
• W2099452973 cites W2103946141 @default.
• W2099452973 cites W2125683177 @default.
• W2099452973 cites W2126328573 @default.
• W2099452973 cites W2134912263 @default.
• W2099452973 cites W2138684097 @default.
• W2099452973 cites W2146712080 @default.
• W2099452973 cites W2153019981 @default.
• W2099452973 cites W2157903932 @default.
• W2099452973 cites W4319308372 @default.
• W2099452973 doi "https://doi.org/10.1111/j.1742-7843.2007.00127.x" @default.
• W2099452973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17910613" @default.
• W2099452973 hasPublicationYear "2007" @default.
• W2099452973 type Work @default.
• W2099452973 sameAs 2099452973 @default.
• W2099452973 citedByCount "37" @default.
• W2099452973 countsByYear W20994529732012 @default.
• W2099452973 countsByYear W20994529732013 @default.
• W2099452973 countsByYear W20994529732014 @default.
• W2099452973 countsByYear W20994529732015 @default.
• W2099452973 countsByYear W20994529732016 @default.
• W2099452973 countsByYear W20994529732017 @default.
• W2099452973 countsByYear W20994529732018 @default.
• W2099452973 countsByYear W20994529732019 @default.
• W2099452973 countsByYear W20994529732020 @default.
• W2099452973 countsByYear W20994529732021 @default.
• W2099452973 crossrefType "journal-article" @default.
• W2099452973 hasAuthorship W2099452973A5003435929 @default.
• W2099452973 hasAuthorship W2099452973A5016889206 @default.
• W2099452973 hasAuthorship W2099452973A5030057156 @default.
• W2099452973 hasAuthorship W2099452973A5059240200 @default.
• W2099452973 hasBestOaLocation W20994529731 @default.
• W2099452973 hasConcept C126322002 @default.
• W2099452973 hasConcept C127413603 @default.
• W2099452973 hasConcept C170493617 @default.
• W2099452973 hasConcept C187345961 @default.
• W2099452973 hasConcept C25498285 @default.
• W2099452973 hasConcept C2776885963 @default.
• W2099452973 hasConcept C2776999253 @default.
• W2099452973 hasConcept C2778122271 @default.
• W2099452973 hasConcept C2780152017 @default.
• W2099452973 hasConcept C2780645631 @default.
• W2099452973 hasConcept C42219234 @default.
• W2099452973 hasConcept C61174792 @default.
• W2099452973 hasConcept C67018056 @default.
• W2099452973 hasConcept C71924100 @default.
• W2099452973 hasConcept C78519656 @default.
• W2099452973 hasConcept C98274493 @default.
• W2099452973 hasConceptScore W2099452973C126322002 @default.
• W2099452973 hasConceptScore W2099452973C127413603 @default.
• W2099452973 hasConceptScore W2099452973C170493617 @default.
• W2099452973 hasConceptScore W2099452973C187345961 @default.
• W2099452973 hasConceptScore W2099452973C25498285 @default.
• W2099452973 hasConceptScore W2099452973C2776885963 @default.
• W2099452973 hasConceptScore W2099452973C2776999253 @default.
• W2099452973 hasConceptScore W2099452973C2778122271 @default.
• W2099452973 hasConceptScore W2099452973C2780152017 @default.
• W2099452973 hasConceptScore W2099452973C2780645631 @default.
• W2099452973 hasConceptScore W2099452973C42219234 @default.
• W2099452973 hasConceptScore W2099452973C61174792 @default.
• W2099452973 hasConceptScore W2099452973C67018056 @default.
• W2099452973 hasConceptScore W2099452973C71924100 @default.
• W2099452973 hasConceptScore W2099452973C78519656 @default.
• W2099452973 hasConceptScore W2099452973C98274493 @default.
• W2099452973 hasIssue "5" @default.
• W2099452973 hasLocation W20994529731 @default.

• next