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- W2099456670 abstract "The mitochondrial respiratory chain produces reactive oxygen species (ROS) during normal electron transport. Despite producing ROS, mitochondria are vulnerable to oxidative stress. Mitochondrial dysfunction has been associated with many degenerative diseases, making it important to identify compounds that protect mitochondria from ROS‐mediated toxicity. Here we report that ciclopirox (CPX) blocks H 2 O 2 ‐induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Δ ψm ). CPX completely blocked H 2 O 2 ‐stimulated release of lactate dehydrogenase (a marker of cell death) and decrease in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK‐HEP‐1 cells. H 2 O 2 rapidly depolarized the Δ ψm , and CPX blocked this H 2 O 2 ‐stimulated Δ ψm decrease. Similar data were obtained in experiments using mitochondria isolated from rat liver. Furthermore, CPX effectively inhibited H 2 O 2 ‐induced mitochondrial permeability transition pore (MPTP) opening. In de‐energized mitochondria, however, CPX did not inhibit Ca 2+ ‐evoked MPTP opening, indicating that CPX is not a direct inhibitor of the MPTP. Oxygen consumption studies showed that in the presence of pyruvate and malate CPX restored the rate of state 3 to state 4 respiration decreased by H 2 O 2 . Consistent with this, CPX replenished ATP levels lowered by H 2 O 2 . The present results indicate that CPX protects SK‐HEP‐1 cells from H 2 O 2 cytotoxicity by inhibiting Δ ψm decrease and indirectly preventing MPTP opening. British Journal of Pharmacology (2005) 145 , 469–476. doi: 10.1038/sj.bjp.0706206" @default.
- W2099456670 created "2016-06-24" @default.
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- W2099456670 date "2005-06-01" @default.
- W2099456670 modified "2023-10-17" @default.
- W2099456670 title "Ciclopirox protects mitochondria from hydrogen peroxide toxicity" @default.
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- W2099456670 doi "https://doi.org/10.1038/sj.bjp.0706206" @default.
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