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- W2099465497 abstract "A novel series of 1‐(thiophen‐2‐yl)‐9 H ‐pyrido [3,4‐ b ]indole derivatives were synthesized using DL ‐tryptophan as starting material. All the compounds were characterized by spectral analysis such as 1 H NMR , Mass, IR , elemental analysis and evaluated for inhibitory potency against HIV ‐1 replication. Among the reported analogues, compound 7g exhibited significant anti‐ HIV activity with EC 50 0.53 μ m and selectivity index 483; compounds 7e , 7i , and 7o displayed moderate activity with EC 50 3.8, 3.8, and 2.8 μ m and selectivity index >105, >105, and 3.85, respectively. Interestingly, compound 7g inhibited p24 antigen expression in acute HIV ‐1 IIIB infected cell line C8166 with EC 50 1.1 μ m . In this study, we also reported the Lipinski rule of 5 parameters, predicted toxicity profile, drug‐likeness, and drug score of the synthesized analogues." @default.
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- W2099465497 date "2014-11-06" @default.
- W2099465497 modified "2023-10-04" @default.
- W2099465497 title "Design, Synthesis, and Biological Evaluation of 1-(thiophen-2-yl)-9<i>H</i>-pyrido[3,4-<i>b</i>]indole Derivatives as Anti-HIV-1 Agents" @default.
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- W2099465497 doi "https://doi.org/10.1111/cbdd.12456" @default.
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