Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099471224> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2099471224 endingPage "694" @default.
- W2099471224 startingPage "685" @default.
- W2099471224 abstract "Several α-melanotropin (α-MSH) analogues with para substituted aromatic and nonaromatic amino acids in the 7-position of the hormone were prepared and their melanotropic activities determined in the frog (Rana pipiens) and lizard (Anolis carolinensis) skin bioassays. D and L-Phe(p-NO2), D- and L-Tyr, D- and L-Ala, and Gly were substituted in the 7-position. The use of substituted D or L-aromatic amino acids in the 7th position of the central Ac-[Nle4] -α-MSH4–11 - NH2 fragment resulted in a loss in potency relative to the corresponding phenylalanine-containing analogue. The loss in potency cannot be due entirely to steric hindrance at the melanophore receptor, since nonaromatic amino acids substituted in the 7th position of this octapeptide fragment also generally led to a loss in biological activity. We reported previously that replacement of phenylalanine-7 by its D enantiomer led to a marked increase in potency in each fragment analogue tested. Analogues containing other D amino acids in the 7th position also were more potent than their L amino acid-containing analogues with one exception: Ac-[Nle4, Ala7]-α-MSH4–11-NH2 was more potent than Ac-[Nle4, D-Ala7]-α-MSH4–11-NH2 in the frog skin bioassay. Replacement of phenylalanine-7 by glycine resulted in a large decrease in potency in both bioassays, illustrating the importance of the side chain group, in this position of α-MSH, to biological potency of the hormone." @default.
- W2099471224 created "2016-06-24" @default.
- W2099471224 creator A5005713744 @default.
- W2099471224 creator A5015632214 @default.
- W2099471224 creator A5030613467 @default.
- W2099471224 creator A5071668584 @default.
- W2099471224 creator A5076760321 @default.
- W2099471224 date "2009-01-12" @default.
- W2099471224 modified "2023-09-24" @default.
- W2099471224 title "Comparative biological activities of potent analogues of α-melanotropin" @default.
- W2099471224 cites W1508660970 @default.
- W2099471224 cites W1513008031 @default.
- W2099471224 cites W1964847660 @default.
- W2099471224 cites W1970716955 @default.
- W2099471224 cites W1975066452 @default.
- W2099471224 cites W1990332976 @default.
- W2099471224 cites W1990641940 @default.
- W2099471224 cites W2000251108 @default.
- W2099471224 cites W2005577583 @default.
- W2099471224 cites W2017470279 @default.
- W2099471224 cites W2017960049 @default.
- W2099471224 cites W2024827335 @default.
- W2099471224 cites W2025871035 @default.
- W2099471224 cites W2040051140 @default.
- W2099471224 cites W2042790746 @default.
- W2099471224 cites W2048528168 @default.
- W2099471224 cites W2061117194 @default.
- W2099471224 cites W2063830468 @default.
- W2099471224 cites W2081093272 @default.
- W2099471224 cites W2085513357 @default.
- W2099471224 cites W2087730018 @default.
- W2099471224 cites W2122695273 @default.
- W2099471224 cites W2149430538 @default.
- W2099471224 doi "https://doi.org/10.1111/j.1399-3011.1986.tb01066.x" @default.
- W2099471224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3489682" @default.
- W2099471224 hasPublicationYear "2009" @default.
- W2099471224 type Work @default.
- W2099471224 sameAs 2099471224 @default.
- W2099471224 citedByCount "4" @default.
- W2099471224 crossrefType "journal-article" @default.
- W2099471224 hasAuthorship W2099471224A5005713744 @default.
- W2099471224 hasAuthorship W2099471224A5015632214 @default.
- W2099471224 hasAuthorship W2099471224A5030613467 @default.
- W2099471224 hasAuthorship W2099471224A5071668584 @default.
- W2099471224 hasAuthorship W2099471224A5076760321 @default.
- W2099471224 hasConcept C104488531 @default.
- W2099471224 hasConcept C116073593 @default.
- W2099471224 hasConcept C185592680 @default.
- W2099471224 hasConcept C18903297 @default.
- W2099471224 hasConcept C201194858 @default.
- W2099471224 hasConcept C202751555 @default.
- W2099471224 hasConcept C2777431362 @default.
- W2099471224 hasConcept C515207424 @default.
- W2099471224 hasConcept C55493867 @default.
- W2099471224 hasConcept C57992300 @default.
- W2099471224 hasConcept C71240020 @default.
- W2099471224 hasConcept C86803240 @default.
- W2099471224 hasConceptScore W2099471224C104488531 @default.
- W2099471224 hasConceptScore W2099471224C116073593 @default.
- W2099471224 hasConceptScore W2099471224C185592680 @default.
- W2099471224 hasConceptScore W2099471224C18903297 @default.
- W2099471224 hasConceptScore W2099471224C201194858 @default.
- W2099471224 hasConceptScore W2099471224C202751555 @default.
- W2099471224 hasConceptScore W2099471224C2777431362 @default.
- W2099471224 hasConceptScore W2099471224C515207424 @default.
- W2099471224 hasConceptScore W2099471224C55493867 @default.
- W2099471224 hasConceptScore W2099471224C57992300 @default.
- W2099471224 hasConceptScore W2099471224C71240020 @default.
- W2099471224 hasConceptScore W2099471224C86803240 @default.
- W2099471224 hasIssue "6" @default.
- W2099471224 hasLocation W20994712241 @default.
- W2099471224 hasLocation W20994712242 @default.
- W2099471224 hasOpenAccess W2099471224 @default.
- W2099471224 hasPrimaryLocation W20994712241 @default.
- W2099471224 hasRelatedWork W1599715067 @default.
- W2099471224 hasRelatedWork W1981229103 @default.
- W2099471224 hasRelatedWork W1987220066 @default.
- W2099471224 hasRelatedWork W2011920770 @default.
- W2099471224 hasRelatedWork W2019122761 @default.
- W2099471224 hasRelatedWork W2090290655 @default.
- W2099471224 hasRelatedWork W2093862344 @default.
- W2099471224 hasRelatedWork W2099471224 @default.
- W2099471224 hasRelatedWork W2988592540 @default.
- W2099471224 hasRelatedWork W2065660933 @default.
- W2099471224 hasVolume "27" @default.
- W2099471224 isParatext "false" @default.
- W2099471224 isRetracted "false" @default.
- W2099471224 magId "2099471224" @default.
- W2099471224 workType "article" @default.