Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099472238> ?p ?o ?g. }
- W2099472238 abstract "Bacterial cancer therapy is a concept more than 100 years old - yet, all things considered, it is still in early development. While the use of many passive therapeutics is hindered by the complexity of tumor biology, bacteria offer unique features that can overcome these limitations. Microbial metabolism, motility and sensitivity can lead to site-specific treatment, highly focused on the tumor and safe to other tissues. Activation of tumor-specific immunity is another important mechanism of such therapies. Several bacterial strains have been evaluated as cancer therapeutics so far, Salmonella Typhimurium being one of the most promising. S. Typhimurium and its derivatives have been used both as direct tumoricidal agents and as cancer vaccine vectors. VNP20009, an attenuated mutant of S. Typhimurium, shows significant native toxicity against murine tumors and was studied in a first-in-man phase I clinical trial for toxicity and anticancer activity. While proved to be safe in cancer patients, insufficient tumor colonization of VNP20009 was identified as a major limitation for further clinical development. Antibody-fragment-based targeting of cancer cells is one of the few approaches proposed to overcome this drawback." @default.
- W2099472238 created "2016-06-24" @default.
- W2099472238 creator A5011676658 @default.
- W2099472238 creator A5045461602 @default.
- W2099472238 creator A5071551125 @default.
- W2099472238 creator A5074068851 @default.
- W2099472238 date "2013-07-05" @default.
- W2099472238 modified "2023-10-14" @default.
- W2099472238 title "Salmonella and cancer: from pathogens to therapeutics." @default.
- W2099472238 cites W120179083 @default.
- W2099472238 cites W143157507 @default.
- W2099472238 cites W1484817497 @default.
- W2099472238 cites W1510865194 @default.
- W2099472238 cites W1515269881 @default.
- W2099472238 cites W1536249747 @default.
- W2099472238 cites W1546823560 @default.
- W2099472238 cites W1798512519 @default.
- W2099472238 cites W1919759039 @default.
- W2099472238 cites W1938034723 @default.
- W2099472238 cites W1964065596 @default.
- W2099472238 cites W1964108510 @default.
- W2099472238 cites W1964822107 @default.
- W2099472238 cites W1965912821 @default.
- W2099472238 cites W1966130292 @default.
- W2099472238 cites W1966351266 @default.
- W2099472238 cites W1967992429 @default.
- W2099472238 cites W1971412620 @default.
- W2099472238 cites W1977686084 @default.
- W2099472238 cites W1978513643 @default.
- W2099472238 cites W1979507175 @default.
- W2099472238 cites W1979960455 @default.
- W2099472238 cites W1990076541 @default.
- W2099472238 cites W1991860284 @default.
- W2099472238 cites W1995564543 @default.
- W2099472238 cites W1996239683 @default.
- W2099472238 cites W1997005784 @default.
- W2099472238 cites W2000225649 @default.
- W2099472238 cites W2006353047 @default.
- W2099472238 cites W2007642628 @default.
- W2099472238 cites W2011067750 @default.
- W2099472238 cites W2012611655 @default.
- W2099472238 cites W2017090013 @default.
- W2099472238 cites W2018056701 @default.
- W2099472238 cites W2019772285 @default.
- W2099472238 cites W2020661064 @default.
- W2099472238 cites W2022980605 @default.
- W2099472238 cites W2023594725 @default.
- W2099472238 cites W2028466368 @default.
- W2099472238 cites W2029466803 @default.
- W2099472238 cites W2031351453 @default.
- W2099472238 cites W2034420518 @default.
- W2099472238 cites W2035878965 @default.
- W2099472238 cites W2037051030 @default.
- W2099472238 cites W2043617535 @default.
- W2099472238 cites W2046105954 @default.
- W2099472238 cites W2046894146 @default.
- W2099472238 cites W2047117366 @default.
- W2099472238 cites W2049049721 @default.
- W2099472238 cites W2051630712 @default.
- W2099472238 cites W2054717287 @default.
- W2099472238 cites W2057650563 @default.
- W2099472238 cites W2058235525 @default.
- W2099472238 cites W2058550226 @default.
- W2099472238 cites W2064580048 @default.
- W2099472238 cites W2073864358 @default.
- W2099472238 cites W2077098686 @default.
- W2099472238 cites W2077496684 @default.
- W2099472238 cites W2079374141 @default.
- W2099472238 cites W2082013458 @default.
- W2099472238 cites W2084586968 @default.
- W2099472238 cites W2084822737 @default.
- W2099472238 cites W2086332218 @default.
- W2099472238 cites W2087906374 @default.
- W2099472238 cites W2088291142 @default.
- W2099472238 cites W2088592373 @default.
- W2099472238 cites W2097221730 @default.
- W2099472238 cites W2097888283 @default.
- W2099472238 cites W2097996896 @default.
- W2099472238 cites W2100388833 @default.
- W2099472238 cites W2101647433 @default.
- W2099472238 cites W2101706701 @default.
- W2099472238 cites W2105548768 @default.
- W2099472238 cites W2111176922 @default.
- W2099472238 cites W2111372869 @default.
- W2099472238 cites W2112010454 @default.
- W2099472238 cites W2115998125 @default.
- W2099472238 cites W2117628715 @default.
- W2099472238 cites W2120008778 @default.
- W2099472238 cites W2120576045 @default.
- W2099472238 cites W2127598826 @default.
- W2099472238 cites W2127946912 @default.
- W2099472238 cites W2128677869 @default.
- W2099472238 cites W2131722151 @default.
- W2099472238 cites W2137749186 @default.
- W2099472238 cites W2139115350 @default.
- W2099472238 cites W2141902291 @default.
- W2099472238 cites W2142189619 @default.
- W2099472238 cites W2143036860 @default.
- W2099472238 cites W2146288137 @default.
- W2099472238 cites W2148052765 @default.