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• W2099472486 abstract "Rheumatic diseases encompass a wide range of conditions of poorly characterized etiopathology, many having both genetic and environmental susceptibility factors. Epigenetic studies are providing new insights into disease pathogenesis. Recent rheumatology literature related to DNA methylation studies-both epigenome-wide and candidate gene-are discussed, as well as methodological issues.A PubMed search for articles published until April 2013 was conducted using the following keywords: (methylation OR epigenetics) AND (rheumatoid arthritis OR lupus OR autoimmune disease OR osteoporosis OR osteoarthritis OR musculoskeletal disorder) and EWAS. The reference lists of identified articles were searched for further articles.Several genome-wide methylation studies have been reported recently, mostly in autoimmune rheumatic diseases. Overall, these studies have identified methylation signatures in disease, clustering of subgroups as well as new and known epigenetic associations. Methodological issues, small sample sizes and reduced coverage of methylation assays render many results preliminary.There have been a number of epigenetic advances in rheumatic diseases recently. The new technologies and emerging field of epigenome-wide association will provide novel perspectives in disease etiology, diagnosis, classification, and therapy." @default.
• W2099472486 created "2016-06-24" @default.
• W2099472486 creator A5002163035 @default.
• W2099472486 creator A5029476220 @default.
• W2099472486 creator A5054779890 @default.
• W2099472486 date "2014-04-01" @default.
• W2099472486 modified "2023-09-23" @default.
• W2099472486 title "Epigenetics and methylation in the rheumatic diseases" @default.
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• W2099472486 doi "https://doi.org/10.1016/j.semarthrit.2013.10.003" @default.
• W2099472486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24231066" @default.
• W2099472486 hasPublicationYear "2014" @default.
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