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- W2099478560 abstract "Although the increased risk of premature heart disease in type 1 diabetes has been recognized for some time, the underlying pathogenesis is still poorly understood. The most likely factor, a priori, to account for this increased risk is hyperglycemia. However, despite recent evidence from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study that prior intensive glycemic control reduces cardiovascular disease (CVD), the epidemiologic association between glycemia and coronary heart disease (CHD) is surprisingly weak. This paradox is a focus of the current review, which also evaluates other major determinants of coronary artery disease (CAD) in type 1 diabetes, including the roles of insulin resistance, cytokines, inflammatory biomarkers, and, briefly, genetic factors. Finally, the clinical implications of this information are discussed.A high occurrence of, and mortality from, CHD in type 1 diabetes has been documented since the late 1970s (1,2). A 1984 registry reported a 10-fold or greater CHD mortality compared with that expected from U.S. national data (3). This very high relative risk, partly reflecting the extremely low CHD death rate in the general young-adult population, was subsequently confirmed by Joslin investigators (4), who reported that those with type 1 diabetes by 55 years of age experienced a sixfold greater cumulative CHD mortality compared with the rate expected using Framingham Study data. The Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) also reported a standardized mortality ratio (SMR) from ischemic heart disease of 9.1 (for men) and 13.5 (for women) for those with a diabetes diagnosis before 30 years of age (5).Two recent prospective epidemiologic studies, the Pittsburgh Epidemiology of Diabetes Complications (EDC) study (6) and Eurodiab (7), a multicenter, clinic-based study in Europe, confirmed these earlier reports and reported an incidence of total coronary events (including electrocardiogram [ECG] changes) …" @default.
- W2099478560 created "2016-06-24" @default.
- W2099478560 creator A5005102981 @default.
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- W2099478560 creator A5052856867 @default.
- W2099478560 creator A5053959156 @default.
- W2099478560 date "2006-11-01" @default.
- W2099478560 modified "2023-10-05" @default.
- W2099478560 title "Type 1 Diabetes and Coronary Artery Disease" @default.
- W2099478560 cites W133453726 @default.
- W2099478560 cites W1502524639 @default.
- W2099478560 cites W1569867225 @default.
- W2099478560 cites W166621268 @default.
- W2099478560 cites W1667957779 @default.
- W2099478560 cites W1814644851 @default.
- W2099478560 cites W1966307362 @default.
- W2099478560 cites W1969859915 @default.
- W2099478560 cites W1970598389 @default.
- W2099478560 cites W1971131796 @default.
- W2099478560 cites W1971439798 @default.
- W2099478560 cites W1975125777 @default.
- W2099478560 cites W1980668148 @default.
- W2099478560 cites W1981232461 @default.
- W2099478560 cites W1981261500 @default.
- W2099478560 cites W1984561364 @default.
- W2099478560 cites W1987170870 @default.
- W2099478560 cites W1988250078 @default.
- W2099478560 cites W1993399636 @default.
- W2099478560 cites W1997005770 @default.
- W2099478560 cites W1997101648 @default.
- W2099478560 cites W1998206832 @default.
- W2099478560 cites W1999165003 @default.
- W2099478560 cites W2000890755 @default.
- W2099478560 cites W2001544711 @default.
- W2099478560 cites W2004673584 @default.
- W2099478560 cites W2005935529 @default.
- W2099478560 cites W2006985588 @default.
- W2099478560 cites W2008232272 @default.
- W2099478560 cites W2010496144 @default.
- W2099478560 cites W2011513745 @default.
- W2099478560 cites W2012063435 @default.
- W2099478560 cites W2012749910 @default.
- W2099478560 cites W2012809706 @default.
- W2099478560 cites W2013524893 @default.
- W2099478560 cites W2015917040 @default.
- W2099478560 cites W2015959086 @default.
- W2099478560 cites W2018152764 @default.
- W2099478560 cites W2021341468 @default.
- W2099478560 cites W2021875549 @default.
- W2099478560 cites W2022206315 @default.
- W2099478560 cites W2028467547 @default.
- W2099478560 cites W2033964057 @default.
- W2099478560 cites W2039352760 @default.
- W2099478560 cites W2040119629 @default.
- W2099478560 cites W2040725678 @default.
- W2099478560 cites W2041294505 @default.
- W2099478560 cites W2041646451 @default.
- W2099478560 cites W2042068980 @default.
- W2099478560 cites W2045599577 @default.
- W2099478560 cites W2046751658 @default.
- W2099478560 cites W2047641691 @default.
- W2099478560 cites W2047676937 @default.
- W2099478560 cites W2048728045 @default.
- W2099478560 cites W2051884485 @default.
- W2099478560 cites W2054603499 @default.
- W2099478560 cites W2054785925 @default.
- W2099478560 cites W2054965006 @default.
- W2099478560 cites W2057567286 @default.
- W2099478560 cites W2057698273 @default.
- W2099478560 cites W2058224902 @default.
- W2099478560 cites W2062384018 @default.
- W2099478560 cites W2063936663 @default.
- W2099478560 cites W2065697164 @default.
- W2099478560 cites W2067679923 @default.
- W2099478560 cites W2067787078 @default.
- W2099478560 cites W2068150037 @default.
- W2099478560 cites W2068359901 @default.
- W2099478560 cites W2068485932 @default.
- W2099478560 cites W2068684373 @default.
- W2099478560 cites W2069959009 @default.
- W2099478560 cites W2074680189 @default.
- W2099478560 cites W2076881073 @default.
- W2099478560 cites W2077498612 @default.
- W2099478560 cites W2078698271 @default.
- W2099478560 cites W2078757199 @default.
- W2099478560 cites W2079871987 @default.
- W2099478560 cites W2082605744 @default.
- W2099478560 cites W2083110820 @default.
- W2099478560 cites W2083659471 @default.
- W2099478560 cites W2084413838 @default.
- W2099478560 cites W2084626868 @default.
- W2099478560 cites W2085070381 @default.
- W2099478560 cites W2085369605 @default.
- W2099478560 cites W2085602501 @default.
- W2099478560 cites W2086243072 @default.
- W2099478560 cites W2090173574 @default.
- W2099478560 cites W2090338227 @default.
- W2099478560 cites W2096473999 @default.