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• W2099502405 abstract "The term metaplasticity refers to the modulation of the ability to induce synaptic plasticity of the form of long-term potentiation (LTP) or long-term depression (LTD) following prior activation of the synapses. While often electrophysiological manipulations are used to demonstrate this phenomenon, prior behavioral manipulations such as exposure to stress were also found to affect the ability to induce LTP and LTD. Interestingly, amygdala stimulation was found to have effects on subsequent LTP induction that resemble those of stress. Here, we report that exposure to stress or basolateral amygdala (BLA) stimulation induces a form of metaplasticity, which prevents the ability of a second episode of stress or BLA activation to suppress LTP in the ventral hippocampus-medial prefrontal cortex (mPFC) pathway. This form of metaplasticity is N-methyl-D-aspartic acid (NMDA)-dependent since the injection of the NMDA partial agonist D-cycloserine prevented the inhibition of LTP induced by prior exposure of stress or BLA activation. Furthermore, blocking NMDA receptors by MK801 before the exposure to stress prevented the ability of the emotional manipulation to inhibit the subsequent modulation of plasticity, resulting in impaired LTP in the mPFC. Taken together, these findings demonstrate a new form of NMDA-dependent emotional metaplasticity in the ventral hippocampus-mPFC pathway." @default.
• W2099502405 created "2016-06-24" @default.
• W2099502405 creator A5002158058 @default.
• W2099502405 creator A5019562081 @default.
• W2099502405 date "2010-01-15" @default.
• W2099502405 modified "2023-10-16" @default.
• W2099502405 title "Stress and Amygdala Suppression of Metaplasticity in the Medial Prefrontal Cortex" @default.
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• W2099502405 doi "https://doi.org/10.1093/cercor/bhp311" @default.
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