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- W2099512500 abstract "A vicious circle of sleep disorder and chronic pain has been nvisaged in recent years. Clearly, painful stimulimaycausearousal nd awakening; however, deprivation of sleepmay aswell increase he perception of pain as demonstrated by experimental data, upported also by clinical studies [1]. Mechanisms of action leadng to lower pain thresholds in sleep deprivation are not as yet stablished. Using pain hypersensitivity models being unrelated to leep, previous investigations in mice and rats indicate that spinal xidative stress may play a role, an observation which is further upported in recent studies [2,3]. In the present issue of the Joural, a paper by Wei et al. [4] is testing the hypothesis whether pinal oxidative stressmay contribute to pain-like hypersensitivity nduced by REM (rapid-eye-movement) sleep deprivation. Using n experimental technique that included intrathecal administraion of antioxidants and a reactive oxygen species (ROS) donor, the uthors provide new knowledge by indicating oxidative stress as a ontributing link between sleep deprivation and the generation of ain." @default.
- W2099512500 created "2016-06-24" @default.
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- W2099512500 date "2011-04-01" @default.
- W2099512500 modified "2023-10-04" @default.
- W2099512500 title "Poor sleep and pain: Does spinal oxidative stress play a role?" @default.
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- W2099512500 doi "https://doi.org/10.1016/j.sjpain.2011.03.001" @default.
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