FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099520227> ?p ?o ?g. }

• W2099520227 endingPage "1198" @default.
• W2099520227 startingPage "1191" @default.
• W2099520227 abstract "Abstract The activity of growth factors is crucial for tumor progression. We previously characterized a secreted fibroblast growth factor–binding protein (FGF-BP1) as a chaperone molecule, which enhances the biological functions of FGFs by releasing FGFs from the extracellular matrix. Here, we characterize the frequency and pattern of FGF-BP1 expression during the malignant progression of pancreas and colorectal carcinoma. For this, we generated monoclonal antibodies that detect FGF-BP1 protein in formalin-fixed, paraffin-embedded tissues and applied in situ hybridization to detect FGF-BP1 mRNA in adjacent tissue sections. FGF-BP1 protein and mRNA were found up-regulated (&gt;70% positive) in parallel (r = 0.70, P &lt; 0.0001) in colon adenoma (n = 9) as well as primary (n = 46) and metastatic (n = 71) colorectal cancers relative to normal colon epithelia (all P &lt; 0.0001, versus normal). Similarly, pancreatitis (n = 17), pancreatic intraepithelial neoplasia (n = 80), and pancreatic adenocarcinoma (n = 67) showed a significant up-regulation of FGF-BP1 compared with normal pancreas (n = 42; all P &lt; 0.0001, relative to normal). Furthermore, the biological activity of FGF-BP1 is neutralized by one of the antibodies, suggesting the potential for antibody-based therapeutic targeting. We propose that the up-regulation of the secreted FGF-BP1 protein during initiation of pancreas and colon neoplasia could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions. (Cancer Res 2006; 66(2): 1191-8)" @default.
• W2099520227 created "2016-06-24" @default.
• W2099520227 creator A5016983822 @default.
• W2099520227 creator A5031572649 @default.
• W2099520227 creator A5037314856 @default.
• W2099520227 creator A5048073439 @default.
• W2099520227 creator A5048768333 @default.
• W2099520227 creator A5066053536 @default.
• W2099520227 creator A5071384045 @default.
• W2099520227 creator A5076845153 @default.
• W2099520227 date "2006-01-15" @default.
• W2099520227 modified "2023-10-14" @default.
• W2099520227 title "Expression of a Fibroblast Growth Factor–Binding Protein during the Development of Adenocarcinoma of the Pancreas and Colon" @default.
• W2099520227 cites W1531658692 @default.
• W2099520227 cites W1581923812 @default.
• W2099520227 cites W1808638478 @default.
• W2099520227 cites W1965081294 @default.
• W2099520227 cites W1968428223 @default.
• W2099520227 cites W1974024713 @default.
• W2099520227 cites W1980447806 @default.
• W2099520227 cites W1982509041 @default.
• W2099520227 cites W1985804036 @default.
• W2099520227 cites W1988323532 @default.
• W2099520227 cites W1992534738 @default.
• W2099520227 cites W1992928961 @default.
• W2099520227 cites W1999926496 @default.
• W2099520227 cites W2007692648 @default.
• W2099520227 cites W2021485034 @default.
• W2099520227 cites W2030522563 @default.
• W2099520227 cites W2030747778 @default.
• W2099520227 cites W2032499003 @default.
• W2099520227 cites W2033351371 @default.
• W2099520227 cites W2034269086 @default.
• W2099520227 cites W2046172352 @default.
• W2099520227 cites W2048967458 @default.
• W2099520227 cites W2051450207 @default.
• W2099520227 cites W2059972525 @default.
• W2099520227 cites W2061716134 @default.
• W2099520227 cites W2076415360 @default.
• W2099520227 cites W2088743964 @default.
• W2099520227 cites W2091651881 @default.
• W2099520227 cites W2095478806 @default.
• W2099520227 cites W2122295620 @default.
• W2099520227 cites W2124606152 @default.
• W2099520227 cites W2125871683 @default.
• W2099520227 cites W2138178479 @default.
• W2099520227 cites W2158743409 @default.
• W2099520227 cites W2335310975 @default.
• W2099520227 doi "https://doi.org/10.1158/0008-5472.can-05-2926" @default.
• W2099520227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16424058" @default.
• W2099520227 hasPublicationYear "2006" @default.
• W2099520227 type Work @default.
• W2099520227 sameAs 2099520227 @default.
• W2099520227 citedByCount "42" @default.
• W2099520227 countsByYear W20995202272012 @default.
• W2099520227 countsByYear W20995202272013 @default.
• W2099520227 countsByYear W20995202272014 @default.
• W2099520227 countsByYear W20995202272015 @default.
• W2099520227 countsByYear W20995202272016 @default.
• W2099520227 countsByYear W20995202272017 @default.
• W2099520227 countsByYear W20995202272018 @default.
• W2099520227 countsByYear W20995202272019 @default.
• W2099520227 countsByYear W20995202272021 @default.
• W2099520227 countsByYear W20995202272022 @default.
• W2099520227 countsByYear W20995202272023 @default.
• W2099520227 crossrefType "journal-article" @default.
• W2099520227 hasAuthorship W2099520227A5016983822 @default.
• W2099520227 hasAuthorship W2099520227A5031572649 @default.
• W2099520227 hasAuthorship W2099520227A5037314856 @default.
• W2099520227 hasAuthorship W2099520227A5048073439 @default.
• W2099520227 hasAuthorship W2099520227A5048768333 @default.
• W2099520227 hasAuthorship W2099520227A5066053536 @default.
• W2099520227 hasAuthorship W2099520227A5071384045 @default.
• W2099520227 hasAuthorship W2099520227A5076845153 @default.
• W2099520227 hasBestOaLocation W20995202271 @default.
• W2099520227 hasConcept C121608353 @default.
• W2099520227 hasConcept C126322002 @default.
• W2099520227 hasConcept C134018914 @default.
• W2099520227 hasConcept C142724271 @default.
• W2099520227 hasConcept C159654299 @default.
• W2099520227 hasConcept C170493617 @default.
• W2099520227 hasConcept C203014093 @default.
• W2099520227 hasConcept C2778764654 @default.
• W2099520227 hasConcept C2780210213 @default.
• W2099520227 hasConcept C2781182431 @default.
• W2099520227 hasConcept C502942594 @default.
• W2099520227 hasConcept C526805850 @default.
• W2099520227 hasConcept C71924100 @default.
• W2099520227 hasConcept C74373430 @default.
• W2099520227 hasConcept C86803240 @default.
• W2099520227 hasConceptScore W2099520227C121608353 @default.
• W2099520227 hasConceptScore W2099520227C126322002 @default.
• W2099520227 hasConceptScore W2099520227C134018914 @default.
• W2099520227 hasConceptScore W2099520227C142724271 @default.
• W2099520227 hasConceptScore W2099520227C159654299 @default.
• W2099520227 hasConceptScore W2099520227C170493617 @default.
• W2099520227 hasConceptScore W2099520227C203014093 @default.
• W2099520227 hasConceptScore W2099520227C2778764654 @default.

• next