Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099523789> ?p ?o ?g. }
- W2099523789 endingPage "S120" @default.
- W2099523789 startingPage "S107" @default.
- W2099523789 abstract "A decade has passed since the first topical prostaglandin analog was prescribed to reduce intraocular pressure (IOP) for the treatment of glaucoma. Now four prostaglandin analogs are available for clinical use around the world and more are in development. The three most efficacious of these drugs are latanoprost, travoprost, and bimatoprost, and their effects on IOP and aqueous humor dynamics are similar. A consistent finding is a substantial increase in uveoscleral outflow and a less consistent finding is an increase in trabecular outflow facility. Aqueous flow appears to be slightly stimulated as well. Prostaglandin receptors and their associated mRNAs have been located in the trabecular meshwork, ciliary muscle, and sclera, providing evidence that endogenous prostaglandins have a functional role in aqueous humor drainage. Earlier evidence found that topical PG analogs release endogenous prostaglandins. One well-studied mechanism for the enhancement of outflow by prostaglandins is the regulation of matrix metalloproteinases and remodeling of extracellular matrix. Other proposed mechanisms include widening of the connective tissue-filled spaces and changes in the shape of cells. All of these mechanisms alter the permeability of tissues of the outflow pathways leading to changes in outflow resistance and/or outflow rates. This review summarizes recent (since 2000) animal and clinical studies of the effects of topical prostaglandin analogs on aqueous humor dynamics and recent cellular and molecular studies designed to clarify the outflow effects." @default.
- W2099523789 created "2016-06-24" @default.
- W2099523789 creator A5053051072 @default.
- W2099523789 creator A5056637572 @default.
- W2099523789 creator A5091104086 @default.
- W2099523789 date "2008-11-01" @default.
- W2099523789 modified "2023-10-14" @default.
- W2099523789 title "Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction" @default.
- W2099523789 cites W1491678226 @default.
- W2099523789 cites W1492933791 @default.
- W2099523789 cites W1711622231 @default.
- W2099523789 cites W187900115 @default.
- W2099523789 cites W1963522904 @default.
- W2099523789 cites W1968976228 @default.
- W2099523789 cites W1970284085 @default.
- W2099523789 cites W1972345417 @default.
- W2099523789 cites W1977730321 @default.
- W2099523789 cites W1985221337 @default.
- W2099523789 cites W1985689227 @default.
- W2099523789 cites W2000085293 @default.
- W2099523789 cites W2000935282 @default.
- W2099523789 cites W2001622302 @default.
- W2099523789 cites W2002854805 @default.
- W2099523789 cites W2004102565 @default.
- W2099523789 cites W2010608134 @default.
- W2099523789 cites W2015389748 @default.
- W2099523789 cites W2021085898 @default.
- W2099523789 cites W2023905396 @default.
- W2099523789 cites W2024413712 @default.
- W2099523789 cites W2024687535 @default.
- W2099523789 cites W2027629652 @default.
- W2099523789 cites W2028199718 @default.
- W2099523789 cites W2029528322 @default.
- W2099523789 cites W2035009454 @default.
- W2099523789 cites W2037682190 @default.
- W2099523789 cites W2041009121 @default.
- W2099523789 cites W2042080175 @default.
- W2099523789 cites W2042267316 @default.
- W2099523789 cites W2043769051 @default.
- W2099523789 cites W2045830688 @default.
- W2099523789 cites W2048686092 @default.
- W2099523789 cites W2049570329 @default.
- W2099523789 cites W2051918516 @default.
- W2099523789 cites W2056597240 @default.
- W2099523789 cites W2061207844 @default.
- W2099523789 cites W2065437588 @default.
- W2099523789 cites W2065486056 @default.
- W2099523789 cites W2071605868 @default.
- W2099523789 cites W2073300880 @default.
- W2099523789 cites W2074994063 @default.
- W2099523789 cites W2076821022 @default.
- W2099523789 cites W2077590596 @default.
- W2099523789 cites W2077915539 @default.
- W2099523789 cites W2080504583 @default.
- W2099523789 cites W2081283233 @default.
- W2099523789 cites W2083872239 @default.
- W2099523789 cites W2084169631 @default.
- W2099523789 cites W2085448595 @default.
- W2099523789 cites W2086364264 @default.
- W2099523789 cites W2088223428 @default.
- W2099523789 cites W2090868178 @default.
- W2099523789 cites W2100006930 @default.
- W2099523789 cites W2109823798 @default.
- W2099523789 cites W2125107554 @default.
- W2099523789 cites W2127722163 @default.
- W2099523789 cites W2128886702 @default.
- W2099523789 cites W2131833594 @default.
- W2099523789 cites W2136654293 @default.
- W2099523789 cites W2139833082 @default.
- W2099523789 cites W2140290681 @default.
- W2099523789 cites W2161294753 @default.
- W2099523789 cites W2163746393 @default.
- W2099523789 cites W2170476052 @default.
- W2099523789 doi "https://doi.org/10.1016/j.survophthal.2008.08.010" @default.
- W2099523789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2727743" @default.
- W2099523789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19038618" @default.
- W2099523789 hasPublicationYear "2008" @default.
- W2099523789 type Work @default.
- W2099523789 sameAs 2099523789 @default.
- W2099523789 citedByCount "259" @default.
- W2099523789 countsByYear W20995237892012 @default.
- W2099523789 countsByYear W20995237892013 @default.
- W2099523789 countsByYear W20995237892014 @default.
- W2099523789 countsByYear W20995237892015 @default.
- W2099523789 countsByYear W20995237892016 @default.
- W2099523789 countsByYear W20995237892017 @default.
- W2099523789 countsByYear W20995237892018 @default.
- W2099523789 countsByYear W20995237892019 @default.
- W2099523789 countsByYear W20995237892020 @default.
- W2099523789 countsByYear W20995237892021 @default.
- W2099523789 countsByYear W20995237892022 @default.
- W2099523789 countsByYear W20995237892023 @default.
- W2099523789 crossrefType "journal-article" @default.
- W2099523789 hasAuthorship W2099523789A5053051072 @default.
- W2099523789 hasAuthorship W2099523789A5056637572 @default.
- W2099523789 hasAuthorship W2099523789A5091104086 @default.
- W2099523789 hasBestOaLocation W20995237892 @default.
- W2099523789 hasConcept C118487528 @default.