Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099536586> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2099536586 abstract "The treatment of right ventricular failure is closely linked to effects on pulmonary vascular resistance and thus the right ventricular (RV) afterload. Medical therapy includes afterload-decreasing drugs such as nitric oxide and prostacycline. However, current devices for mechanical unloading of the right ventricle aim at a decrease in preload increasing the pulmonary volume loading. In our concept study, we tested a minimally invasive right ventricular assist device (MIRVAD) that specifically reduces the afterload.The MIRVAD is supposed to be a foldable device for temporary transvascular placement in the pulmonary artery. We incorporated a MIRVAD prototype into a mock circulatory loop that can reproduce haemodynamic interaction between the pump and the physiological system. Pulmonary hypertension (PH), right heart failure (RHF) and MIRVAD-assisted cases were simulated. The key haemodynamic parameters for RV unloading were recorded.Mock loop simulation attested to a sufficient right ventricular unloading by serial application of a miniaturized impeller pump in the pulmonary artery. The afterload, represented by the pulmonary arterial root pressure, was recovered to the healthy range (32.62-10.93 mmHg) for the simulated PH case. In the simulated RHF case, the impaired pulmonary perfusion increased from 43.4 to 88.8% of the healthy level and the total ventricular work reduced from 0.381 to 0.197 J at a pump speed of 3500 rpm. At pump speeds higher than 3500 rpm, the pulmonary valve remains constantly open and the right ventricular configuration changes into a simple perfused hollow body.The feasibility of RV unloading by a selective decrease in RV afterload was proved in principle. By alternation of the pump speed, gradual reloading in sense of a myocardial training may be achieved. The results will be validated by future animal trials where the relationship between the level of support and pulmonary vascular pressure can be investigated in vivo. Further device design concerning foldable impeller leaflets will be carried out. At a final stage, the crimped version is supposed to reach a size below 1 cm to facilitate minimally invasive insertion." @default.
- W2099536586 created "2016-06-24" @default.
- W2099536586 creator A5001054097 @default.
- W2099536586 creator A5009940944 @default.
- W2099536586 creator A5023948123 @default.
- W2099536586 creator A5024996568 @default.
- W2099536586 creator A5048871541 @default.
- W2099536586 creator A5059039862 @default.
- W2099536586 creator A5061203619 @default.
- W2099536586 creator A5066631322 @default.
- W2099536586 creator A5072062278 @default.
- W2099536586 creator A5088160089 @default.
- W2099536586 date "2014-03-26" @default.
- W2099536586 modified "2023-09-24" @default.
- W2099536586 title "Selective reduction of afterload in right heart assist therapy: a mock loop study" @default.
- W2099536586 cites W1672779881 @default.
- W2099536586 cites W1978880936 @default.
- W2099536586 cites W1991276230 @default.
- W2099536586 cites W2034445777 @default.
- W2099536586 cites W2132973204 @default.
- W2099536586 cites W2140078760 @default.
- W2099536586 cites W2157217100 @default.
- W2099536586 doi "https://doi.org/10.1093/icvts/ivu067" @default.
- W2099536586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24670773" @default.
- W2099536586 hasPublicationYear "2014" @default.
- W2099536586 type Work @default.
- W2099536586 sameAs 2099536586 @default.
- W2099536586 citedByCount "4" @default.
- W2099536586 countsByYear W20995365862014 @default.
- W2099536586 countsByYear W20995365862017 @default.
- W2099536586 countsByYear W20995365862020 @default.
- W2099536586 countsByYear W20995365862021 @default.
- W2099536586 crossrefType "journal-article" @default.
- W2099536586 hasAuthorship W2099536586A5001054097 @default.
- W2099536586 hasAuthorship W2099536586A5009940944 @default.
- W2099536586 hasAuthorship W2099536586A5023948123 @default.
- W2099536586 hasAuthorship W2099536586A5024996568 @default.
- W2099536586 hasAuthorship W2099536586A5048871541 @default.
- W2099536586 hasAuthorship W2099536586A5059039862 @default.
- W2099536586 hasAuthorship W2099536586A5061203619 @default.
- W2099536586 hasAuthorship W2099536586A5066631322 @default.
- W2099536586 hasAuthorship W2099536586A5072062278 @default.
- W2099536586 hasAuthorship W2099536586A5088160089 @default.
- W2099536586 hasConcept C123576724 @default.
- W2099536586 hasConcept C126322002 @default.
- W2099536586 hasConcept C139940330 @default.
- W2099536586 hasConcept C164705383 @default.
- W2099536586 hasConcept C178853913 @default.
- W2099536586 hasConcept C2778198053 @default.
- W2099536586 hasConcept C2778774980 @default.
- W2099536586 hasConcept C2778921608 @default.
- W2099536586 hasConcept C2780930700 @default.
- W2099536586 hasConcept C2780940725 @default.
- W2099536586 hasConcept C42219234 @default.
- W2099536586 hasConcept C48277249 @default.
- W2099536586 hasConcept C58245268 @default.
- W2099536586 hasConcept C71924100 @default.
- W2099536586 hasConceptScore W2099536586C123576724 @default.
- W2099536586 hasConceptScore W2099536586C126322002 @default.
- W2099536586 hasConceptScore W2099536586C139940330 @default.
- W2099536586 hasConceptScore W2099536586C164705383 @default.
- W2099536586 hasConceptScore W2099536586C178853913 @default.
- W2099536586 hasConceptScore W2099536586C2778198053 @default.
- W2099536586 hasConceptScore W2099536586C2778774980 @default.
- W2099536586 hasConceptScore W2099536586C2778921608 @default.
- W2099536586 hasConceptScore W2099536586C2780930700 @default.
- W2099536586 hasConceptScore W2099536586C2780940725 @default.
- W2099536586 hasConceptScore W2099536586C42219234 @default.
- W2099536586 hasConceptScore W2099536586C48277249 @default.
- W2099536586 hasConceptScore W2099536586C58245268 @default.
- W2099536586 hasConceptScore W2099536586C71924100 @default.
- W2099536586 hasLocation W20995365861 @default.
- W2099536586 hasLocation W20995365862 @default.
- W2099536586 hasOpenAccess W2099536586 @default.
- W2099536586 hasPrimaryLocation W20995365861 @default.
- W2099536586 hasRelatedWork W1996266797 @default.
- W2099536586 hasRelatedWork W2000020652 @default.
- W2099536586 hasRelatedWork W2166962125 @default.
- W2099536586 hasRelatedWork W2169190460 @default.
- W2099536586 hasRelatedWork W2185066832 @default.
- W2099536586 hasRelatedWork W2370205175 @default.
- W2099536586 hasRelatedWork W2405276391 @default.
- W2099536586 hasRelatedWork W2472410476 @default.
- W2099536586 hasRelatedWork W2513447928 @default.
- W2099536586 hasRelatedWork W4220680471 @default.
- W2099536586 isParatext "false" @default.
- W2099536586 isRetracted "false" @default.
- W2099536586 magId "2099536586" @default.
- W2099536586 workType "article" @default.