FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099547048> ?p ?o ?g. }

• W2099547048 endingPage "e1002065" @default.
• W2099547048 startingPage "e1002065" @default.
• W2099547048 abstract "An ability to sense pathogens by a number of specialized cell types including the dendritic cells plays a central role in host's defenses. Activation of these cells through the stimulation of the pathogen-recognition receptors induces the production of a number of cytokines including Type I interferons (IFNs) that mediate the diverse mechanisms of innate immunity. Type I IFNs interact with the Type I IFN receptor, composed of IFNAR1 and IFNAR2 chains, to mount the host defense responses. However, at the same time, Type I IFNs elicit potent anti-proliferative and pro-apoptotic effects that could be detrimental for IFN-producing cells. Here, we report that the activation of p38 kinase in response to pathogen-recognition receptors stimulation results in a series of phosphorylation events within the IFNAR1 chain of the Type I IFN receptor. This phosphorylation promotes IFNAR1 ubiquitination and accelerates the proteolytic turnover of this receptor leading to an attenuation of Type I IFN signaling and the protection of activated dendritic cells from the cytotoxic effects of autocrine or paracrine Type I IFN. In this paper we discuss a potential role of this mechanism in regulating the processes of innate immunity." @default.
• W2099547048 created "2016-06-24" @default.
• W2099547048 creator A5013600050 @default.
• W2099547048 creator A5037447718 @default.
• W2099547048 creator A5041236541 @default.
• W2099547048 creator A5051848486 @default.
• W2099547048 creator A5076213121 @default.
• W2099547048 creator A5077457004 @default.
• W2099547048 creator A5084130569 @default.
• W2099547048 creator A5091065261 @default.
• W2099547048 date "2011-06-09" @default.
• W2099547048 modified "2023-09-24" @default.
• W2099547048 title "Pathogen Recognition Receptor Signaling Accelerates Phosphorylation-Dependent Degradation of IFNAR1" @default.
• W2099547048 cites W1544033113 @default.
• W2099547048 cites W1576499008 @default.
• W2099547048 cites W1599671085 @default.
• W2099547048 cites W1605033827 @default.
• W2099547048 cites W1676455561 @default.
• W2099547048 cites W1971692313 @default.
• W2099547048 cites W1974924668 @default.
• W2099547048 cites W1980768668 @default.
• W2099547048 cites W1986217661 @default.
• W2099547048 cites W1987274954 @default.
• W2099547048 cites W1989752867 @default.
• W2099547048 cites W1992752678 @default.
• W2099547048 cites W1994828005 @default.
• W2099547048 cites W1997965901 @default.
• W2099547048 cites W2004547943 @default.
• W2099547048 cites W2004724554 @default.
• W2099547048 cites W2007666820 @default.
• W2099547048 cites W2014188630 @default.
• W2099547048 cites W2017405330 @default.
• W2099547048 cites W2022651196 @default.
• W2099547048 cites W2025633900 @default.
• W2099547048 cites W2027244390 @default.
• W2099547048 cites W2029010559 @default.
• W2099547048 cites W2034275921 @default.
• W2099547048 cites W2043188148 @default.
• W2099547048 cites W2047861330 @default.
• W2099547048 cites W2056618213 @default.
• W2099547048 cites W2060351820 @default.
• W2099547048 cites W2060745847 @default.
• W2099547048 cites W2062813693 @default.
• W2099547048 cites W2065234696 @default.
• W2099547048 cites W2066028474 @default.
• W2099547048 cites W2066728093 @default.
• W2099547048 cites W2078844752 @default.
• W2099547048 cites W2082538292 @default.
• W2099547048 cites W2089198803 @default.
• W2099547048 cites W2094318390 @default.
• W2099547048 cites W2097262511 @default.
• W2099547048 cites W2100935357 @default.
• W2099547048 cites W2109095539 @default.
• W2099547048 cites W2112385479 @default.
• W2099547048 cites W2116452604 @default.
• W2099547048 cites W2123257865 @default.
• W2099547048 cites W2125100593 @default.
• W2099547048 cites W2128657750 @default.
• W2099547048 cites W2138651252 @default.
• W2099547048 cites W2139669901 @default.
• W2099547048 cites W2141700417 @default.
• W2099547048 cites W2142853998 @default.
• W2099547048 cites W2144099695 @default.
• W2099547048 cites W2148178789 @default.
• W2099547048 cites W2148810559 @default.
• W2099547048 cites W2156313733 @default.
• W2099547048 cites W2157926318 @default.
• W2099547048 cites W2159803503 @default.
• W2099547048 cites W2160313021 @default.
• W2099547048 cites W2166411505 @default.
• W2099547048 cites W2168687405 @default.
• W2099547048 doi "https://doi.org/10.1371/journal.ppat.1002065" @default.
• W2099547048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3111542" @default.
• W2099547048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21695243" @default.
• W2099547048 hasPublicationYear "2011" @default.
• W2099547048 type Work @default.
• W2099547048 sameAs 2099547048 @default.
• W2099547048 citedByCount "39" @default.
• W2099547048 countsByYear W20995470482012 @default.
• W2099547048 countsByYear W20995470482013 @default.
• W2099547048 countsByYear W20995470482014 @default.
• W2099547048 countsByYear W20995470482015 @default.
• W2099547048 countsByYear W20995470482016 @default.
• W2099547048 countsByYear W20995470482017 @default.
• W2099547048 countsByYear W20995470482018 @default.
• W2099547048 countsByYear W20995470482019 @default.
• W2099547048 countsByYear W20995470482020 @default.
• W2099547048 countsByYear W20995470482021 @default.
• W2099547048 countsByYear W20995470482022 @default.
• W2099547048 crossrefType "journal-article" @default.
• W2099547048 hasAuthorship W2099547048A5013600050 @default.
• W2099547048 hasAuthorship W2099547048A5037447718 @default.
• W2099547048 hasAuthorship W2099547048A5041236541 @default.
• W2099547048 hasAuthorship W2099547048A5051848486 @default.
• W2099547048 hasAuthorship W2099547048A5076213121 @default.
• W2099547048 hasAuthorship W2099547048A5077457004 @default.
• W2099547048 hasAuthorship W2099547048A5084130569 @default.
• W2099547048 hasAuthorship W2099547048A5091065261 @default.

• next