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- W2099551469 endingPage "112" @default.
- W2099551469 startingPage "87" @default.
- W2099551469 abstract "This review investigates some key aspects of transport mechanisms and recent advances in our understanding of this ubiquitous cellular process. The prevailing model of cotransport is the alternating access model, which suggests that large conformational changes in the transporter protein accompany cotransport. This model rests on decades of research and has received substantial support because many transporter characteristics are explained using its premises. New experiments, however, have revealed the existence of channels in transporters, an idea that is in conflict with traditional models. The alternating access model is the subject of previous detailed reviews. Here we concentrate on the relatively recent data that document primarily the channel properties of transporters. In some cases, namely, the observation of single-transporter currents, the evidence is direct. In other cases the evidence--for example, from fluctuation analysis or transporter currents too large to be described as anything other than channel-like--is indirect. Although the existence of channels in transporters is not in doubt, we are far from understanding the significance of this property. In the online Supplemental Material , we review some pertinent aspects of ion channel theory and cotransport physiology to provide background for the channels and transporters presented here. We discuss the existence of channels in transporters, and we speculate on the biological significance of this newly unveiled property of transport proteins." @default.
- W2099551469 created "2016-06-24" @default.
- W2099551469 creator A5049876115 @default.
- W2099551469 creator A5051139835 @default.
- W2099551469 date "2007-03-01" @default.
- W2099551469 modified "2023-09-24" @default.
- W2099551469 title "Transporters as Channels" @default.
- W2099551469 cites W1462411641 @default.
- W2099551469 cites W1497611224 @default.
- W2099551469 cites W1522221384 @default.
- W2099551469 cites W1545941184 @default.
- W2099551469 cites W1568628619 @default.
- W2099551469 cites W1575146932 @default.
- W2099551469 cites W1587837383 @default.
- W2099551469 cites W1598676150 @default.
- W2099551469 cites W1609863923 @default.
- W2099551469 cites W1618487358 @default.
- W2099551469 cites W1953585322 @default.
- W2099551469 cites W1964246617 @default.
- W2099551469 cites W1966663884 @default.
- W2099551469 cites W1970425507 @default.
- W2099551469 cites W1972500547 @default.
- W2099551469 cites W1973351968 @default.
- W2099551469 cites W1974935655 @default.
- W2099551469 cites W1975715220 @default.
- W2099551469 cites W1976533269 @default.
- W2099551469 cites W1982140992 @default.
- W2099551469 cites W1983523125 @default.
- W2099551469 cites W1985354493 @default.
- W2099551469 cites W1985670872 @default.
- W2099551469 cites W1987018129 @default.
- W2099551469 cites W1987110948 @default.
- W2099551469 cites W1988384792 @default.
- W2099551469 cites W1990935108 @default.
- W2099551469 cites W1991220984 @default.
- W2099551469 cites W1994088425 @default.
- W2099551469 cites W1994349958 @default.
- W2099551469 cites W1994710858 @default.
- W2099551469 cites W1995087505 @default.
- W2099551469 cites W1995691299 @default.
- W2099551469 cites W1996732956 @default.
- W2099551469 cites W1997107960 @default.
- W2099551469 cites W1997432723 @default.
- W2099551469 cites W1997748997 @default.
- W2099551469 cites W1999452661 @default.
- W2099551469 cites W2002096718 @default.
- W2099551469 cites W2002985134 @default.
- W2099551469 cites W2005501525 @default.
- W2099551469 cites W2008470626 @default.
- W2099551469 cites W2015199368 @default.
- W2099551469 cites W2016532705 @default.
- W2099551469 cites W2016821205 @default.
- W2099551469 cites W2018678300 @default.
- W2099551469 cites W2019870906 @default.
- W2099551469 cites W2019965714 @default.
- W2099551469 cites W2020939449 @default.
- W2099551469 cites W2021676916 @default.
- W2099551469 cites W2023817459 @default.
- W2099551469 cites W2024534908 @default.
- W2099551469 cites W2026271507 @default.
- W2099551469 cites W2026756819 @default.
- W2099551469 cites W2028811283 @default.
- W2099551469 cites W2031130299 @default.
- W2099551469 cites W2031553442 @default.
- W2099551469 cites W2032226112 @default.
- W2099551469 cites W2032734987 @default.
- W2099551469 cites W2032957429 @default.
- W2099551469 cites W2033690159 @default.
- W2099551469 cites W2033829712 @default.
- W2099551469 cites W2036629661 @default.
- W2099551469 cites W2038136908 @default.
- W2099551469 cites W2041836266 @default.
- W2099551469 cites W2046656363 @default.
- W2099551469 cites W2050529989 @default.
- W2099551469 cites W2051918534 @default.
- W2099551469 cites W2052116640 @default.
- W2099551469 cites W2054927476 @default.
- W2099551469 cites W2056828670 @default.
- W2099551469 cites W2057668357 @default.
- W2099551469 cites W2058436800 @default.
- W2099551469 cites W2065878733 @default.
- W2099551469 cites W2067081534 @default.
- W2099551469 cites W2067312729 @default.
- W2099551469 cites W2071307719 @default.
- W2099551469 cites W2072914802 @default.
- W2099551469 cites W2073703547 @default.
- W2099551469 cites W2074807783 @default.
- W2099551469 cites W2078310394 @default.
- W2099551469 cites W2081730365 @default.
- W2099551469 cites W2086843278 @default.
- W2099551469 cites W2087803534 @default.
- W2099551469 cites W2090857098 @default.
- W2099551469 cites W2092358916 @default.
- W2099551469 cites W2094673798 @default.
- W2099551469 cites W2095267065 @default.
- W2099551469 cites W2096664748 @default.
- W2099551469 cites W2104622728 @default.
- W2099551469 cites W2109229946 @default.