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• W2099574788 startingPage "16671" @default.
• W2099574788 abstract "Atherosclerosis is associated with alterations in nitric oxide (NO)/cGMP signaling. In early stages of the disease, inflammatory and possibly other cells produce reactive oxygen species that scavenge vasoprotective NO. In addition to the oxidative stress, expression and activity of enzymes downstream to NO formation may also be affected. Here, we show in the aortas of chronically hypercholesterolemic rabbits (a model of late-stage atherosclerosis), both subunits and specific activity of the NO receptor soluble guanylyl cyclase (sGC) were significantly reduced, whereas overall NO synthase activity was unaffected. These changes were most prominent in the neointimal layer, wherein cGMP-dependent protein kinase I (cGK) levels also were reduced. Additionally, a protein (p38 nt ) that was constitutively tyrosine-nitrated was detected, and its expression was significantly reduced in atherosclerotic aorta. Phosphorylation of the cGK substrate vasodilator-stimulated phosphoprotein (VASP) at Ser-239, an established biochemical endpoint of NO/cGMP signaling, also was reduced. Thus, late-stage atherosclerosis is associated not only with enhanced NO breakdown but also with altered NO reception and cGMP signaling. Preferential down-regulation in neointima suggests a direct connection of these changes to neointimal proliferation and vascular dysfunction and provides a rationale for future pharmacotherapy using classical and novel sGC activators." @default.
• W2099574788 created "2016-06-24" @default.
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• W2099574788 date "2004-11-16" @default.
• W2099574788 modified "2023-09-24" @default.
• W2099574788 title "Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis" @default.
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• W2099574788 cites W1838917319 @default.
• W2099574788 cites W1964885406 @default.
• W2099574788 cites W1966149617 @default.
• W2099574788 cites W1969498857 @default.
• W2099574788 cites W1974766153 @default.
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• W2099574788 cites W1978969417 @default.
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• W2099574788 cites W2095862628 @default.
• W2099574788 cites W2096292525 @default.
• W2099574788 cites W2096964065 @default.
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• W2099574788 cites W2170497762 @default.
• W2099574788 cites W2316918019 @default.
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• W2099574788 doi "https://doi.org/10.1073/pnas.0405509101" @default.
• W2099574788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/534521" @default.
• W2099574788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15546990" @default.
• W2099574788 hasPublicationYear "2004" @default.
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