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• W2099600526 abstract "Cell differentiation and proliferation are coordinated during animal development, but the link between them remains uncharacterized. To examine this relationship, we combined single-molecule RNA imaging with time-lapse microscopy to generate high-resolution measurements of transcriptional dynamics in Caenorhabditis elegans embryogenesis. We found that globally slowing the overall development rate of the embryo by altering temperature or by mutation resulted in cell proliferation and transcription slowing, but maintaining, their relative timings, suggesting that cell division may directly control transcription. However, using mutants with specific defects in cell cycle pathways that lead to abnormal lineages, we found that the order between cell divisions and expression onset can switch, showing that expression of developmental regulators is not strictly dependent on cell division. Delaying cell divisions resulted in only slight changes in absolute expression time, suggesting that expression and proliferation are independently entrained to a separate clock-like process. These changes in relative timing can change the number of cells expressing a gene at a given time, suggesting that timing may help determine which cells adopt particular transcriptional patterns. Our results place limits on the types of mechanisms that are used during normal development to ensure that division timing and fate specification occur at appropriate times." @default.
• W2099600526 created "2016-06-24" @default.
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• W2099600526 date "2013-08-15" @default.
• W2099600526 modified "2023-10-03" @default.
• W2099600526 title "Gene transcription is coordinated with, but not dependent on, cell divisions during <i>C. elegans</i> embryonic fate specification" @default.
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• W2099600526 doi "https://doi.org/10.1242/dev.098012" @default.
• W2099600526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737719" @default.
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