Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099608300> ?p ?o ?g. }
- W2099608300 endingPage "250" @default.
- W2099608300 startingPage "229" @default.
- W2099608300 abstract "The enzyme indoleamine 2,3-dioxygenase (IDO) regulates immune responses through the capacity to degrade the essential amino-acid tryptophan into kynurenine and other downstream metabolites that suppress effector T-cell function and favour the differentiation of regulatory T cells. The current experimental evidence indicates that IDO can be expressed by a variety of cell types, including dendritic cells, tumour cells and stromal cells. Recently, IDO has been implicated in B-cell stimulation and autoantibody production in experimental models of autoimmune diseases.Advances in the biochemistry of IDO and our understanding of the biological relevance of IDO-mediated tryptophan consumption to the establishment of immune tolerance are summarised and discussed. A selection of recent patents in the field are also reviewed and analysed.Readers will gain an overview of the patented compounds with IDO inhibitory activity from an immunologist's perspective. They will also learn about the companies that are main players in the field.Current evidence points to IDO as a molecular target for therapeutic intervention in order to restrain unwanted inflammatory/autoimmune responses and/or to boost antitumour immunity." @default.
- W2099608300 created "2016-06-24" @default.
- W2099608300 creator A5009430017 @default.
- W2099608300 creator A5029407987 @default.
- W2099608300 creator A5032994967 @default.
- W2099608300 creator A5066649201 @default.
- W2099608300 date "2010-01-25" @default.
- W2099608300 modified "2023-10-01" @default.
- W2099608300 title "Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds" @default.
- W2099608300 cites W1479698819 @default.
- W2099608300 cites W1487098616 @default.
- W2099608300 cites W1497497385 @default.
- W2099608300 cites W1498611516 @default.
- W2099608300 cites W1518552940 @default.
- W2099608300 cites W1519089655 @default.
- W2099608300 cites W1530044612 @default.
- W2099608300 cites W1543127122 @default.
- W2099608300 cites W1543787828 @default.
- W2099608300 cites W1563129071 @default.
- W2099608300 cites W1565145471 @default.
- W2099608300 cites W1579633491 @default.
- W2099608300 cites W1598309391 @default.
- W2099608300 cites W1605075022 @default.
- W2099608300 cites W1669486342 @default.
- W2099608300 cites W1781107874 @default.
- W2099608300 cites W1834981029 @default.
- W2099608300 cites W1896500173 @default.
- W2099608300 cites W1899684080 @default.
- W2099608300 cites W1928117283 @default.
- W2099608300 cites W1947375451 @default.
- W2099608300 cites W1964282557 @default.
- W2099608300 cites W1964609124 @default.
- W2099608300 cites W1965296796 @default.
- W2099608300 cites W1966912859 @default.
- W2099608300 cites W1970311191 @default.
- W2099608300 cites W1970319521 @default.
- W2099608300 cites W1970674279 @default.
- W2099608300 cites W1973251492 @default.
- W2099608300 cites W1974401900 @default.
- W2099608300 cites W1975929837 @default.
- W2099608300 cites W1976259414 @default.
- W2099608300 cites W1976707323 @default.
- W2099608300 cites W1977692898 @default.
- W2099608300 cites W1977753547 @default.
- W2099608300 cites W1980841783 @default.
- W2099608300 cites W1981525456 @default.
- W2099608300 cites W1983913853 @default.
- W2099608300 cites W1983923482 @default.
- W2099608300 cites W1986199117 @default.
- W2099608300 cites W1987171603 @default.
- W2099608300 cites W1987772726 @default.
- W2099608300 cites W1988941798 @default.
- W2099608300 cites W1991075838 @default.
- W2099608300 cites W1991295852 @default.
- W2099608300 cites W1991344565 @default.
- W2099608300 cites W1991526830 @default.
- W2099608300 cites W1991753815 @default.
- W2099608300 cites W1994426347 @default.
- W2099608300 cites W1994472314 @default.
- W2099608300 cites W1997582687 @default.
- W2099608300 cites W1998163040 @default.
- W2099608300 cites W1999028733 @default.
- W2099608300 cites W1999228398 @default.
- W2099608300 cites W1999601075 @default.
- W2099608300 cites W2000648336 @default.
- W2099608300 cites W2001070889 @default.
- W2099608300 cites W2003635644 @default.
- W2099608300 cites W2004464588 @default.
- W2099608300 cites W2006654139 @default.
- W2099608300 cites W2008249034 @default.
- W2099608300 cites W2009024574 @default.
- W2099608300 cites W2010343273 @default.
- W2099608300 cites W2010378562 @default.
- W2099608300 cites W2011062975 @default.
- W2099608300 cites W2011447282 @default.
- W2099608300 cites W2011678998 @default.
- W2099608300 cites W2011955626 @default.
- W2099608300 cites W2013729937 @default.
- W2099608300 cites W2015260577 @default.
- W2099608300 cites W2015919529 @default.
- W2099608300 cites W2018234318 @default.
- W2099608300 cites W2018781776 @default.
- W2099608300 cites W2020196369 @default.
- W2099608300 cites W2021888273 @default.
- W2099608300 cites W2022430924 @default.
- W2099608300 cites W2026417201 @default.
- W2099608300 cites W2026429388 @default.
- W2099608300 cites W2028303382 @default.
- W2099608300 cites W2030819248 @default.
- W2099608300 cites W2031585195 @default.
- W2099608300 cites W2032977462 @default.
- W2099608300 cites W2034291192 @default.
- W2099608300 cites W2036247758 @default.
- W2099608300 cites W2038163944 @default.
- W2099608300 cites W2038618605 @default.
- W2099608300 cites W2039183048 @default.
- W2099608300 cites W2040636315 @default.
- W2099608300 cites W2041676299 @default.