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- W2099620922 abstract "Epithelial-to-mesenchymal transitions (EMTs) are crucial for morphogenesis and carcinoma metastasis, yet mechanisms controlling the underlying cell behaviors are poorly understood. RhoGTPase signaling has been implicated in EMT; however, previous studies have yielded conflicting results regarding Rho function, and its role in EMT remains poorly understood. Elucidation of precise Rho functions has been challenging because Rho signaling is highly context dependent and its activity is tightly regulated spatiotemporally within the cell. To date, few studies have examined how Rho affects cell motility in intact organisms, and the pattern of Rho activity during motile cell behaviors of EMT has not been determined in any system. Here, we image endogenous active Rho during EMT in vivo, and analyze effects of Rho and Rho-kinase (ROCK) manipulation on cell motility in vivo. We show that Rho is activated in a discrete apical region of premigratory neural crest cells during EMT, and Rho-ROCK signaling is essential for apical detachment and generation of motility within the neuroepithelium, a process that has been poorly understood. Furthermore, we find that Arhgap1 restricts Rho activation to apical areas, and this restriction is necessary for detachment. Our results provide new insight into mechanisms controlling local Rho activation and how it affects dynamic cell behaviors and actomyosin contraction during key steps of EMT in an intact living organism." @default.
- W2099620922 created "2016-06-24" @default.
- W2099620922 creator A5012361666 @default.
- W2099620922 creator A5060632662 @default.
- W2099620922 date "2013-08-01" @default.
- W2099620922 modified "2023-10-12" @default.
- W2099620922 title "Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition" @default.
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- W2099620922 doi "https://doi.org/10.1242/dev.095448" @default.
- W2099620922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3931734" @default.
- W2099620922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23804498" @default.
- W2099620922 hasPublicationYear "2013" @default.
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