FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099627538> ?p ?o ?g. }

• W2099627538 endingPage "41" @default.
• W2099627538 startingPage "834" @default.
• W2099627538 abstract "2-((2-((Dimethylamino)methyl)phenyl)thio)-5-(123)I-iodophenylamine ((123)I-ADAM) is a new radiopharmaceutical that selectively binds the central nervous system serotonin transporters. The purpose of this study was to measure its whole-body biokinetics and estimate its radiation dosimetry in healthy human volunteers. The study was conducted within a regulatory framework that required its pharmacologic safety to be assessed simultaneously.The sample included 7 subjects ranging in age from 22 to 54 y old. An average of 12.7 whole-body scans were acquired sequentially on a dual-head camera for up to 50 h after the intravenous administration of 185 MBq (5 mCi) (123)I-ADAM. The fraction of the administered dose in 13 regions of interest (ROIs) was quantified from the attenuation-corrected geometric mean counts in conjugate views. Multiexponential functions were iteratively fit to each time-activity curve using a nonlinear, least-squares regression algorithm. These curves were numerically integrated to yield source organ residence times. Gender-specific radiation doses were then estimated with the MIRD technique. SPECT brain scans obtained 3 h after injection were evaluated using an ROI analysis to determine the range of values for the region to cerebellum.There were no pharmacologic effects of the radiotracer on any of the subjects, including no change in heart rate, blood pressure, or laboratory results. Early planar images showed differentially increased activity in the lungs. SPECT images demonstrated that the radiopharmaceutical localized in the midbrain in a distribution that is consistent with selective transporter binding. The dose-limiting organ in both men and women was the distal colon, which received an average of 0.12 mGy/MBq (0.43 rad/mCi) (range, 0.098-0.15 mGy/MBq). The effective dose equivalent and effective dose for (123)I-ADAM were 0.037 +/- 0.003 mSv/MBq and 0.036 +/- 0.003 mSv/MBq, respectively. The mean adult male value of effective dose for (123)I-ADAM is similar in magnitude to that of (111)In-diethylenetriaminepentaacetic acid (0.035 mGy/MBq), half that of (111)In-pentetreotide (0.81 mGy/MBq), and approximately twice that of (123)I-inosine 5'-monophosphate (0.018 mGy/MBq). The differences in results between this study and a previous publication are most likely due to several factors, the most prominent being this dataset used attenuation correction of the scintigraphic data. Region-to-cerebellum ratios for the brain SPECT scans were 1.95 +/- 0.13 for the midbrain, 1.27 +/- 0.10 for the medial temporal regions, and 1.11 +/- 0.07 for the striatum.(123)I-ADAM may be a safe and effective radiotracer for imaging serotonin transporters in the brain and the body." @default.
• W2099627538 created "2016-06-24" @default.
• W2099627538 creator A5033687321 @default.
• W2099627538 creator A5037656770 @default.
• W2099627538 creator A5044095097 @default.
• W2099627538 creator A5044363701 @default.
• W2099627538 creator A5049249441 @default.
• W2099627538 creator A5055131918 @default.
• W2099627538 creator A5056259111 @default.
• W2099627538 creator A5078685289 @default.
• W2099627538 creator A5088003622 @default.
• W2099627538 date "2004-05-01" @default.
• W2099627538 modified "2023-09-23" @default.
• W2099627538 title "Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent." @default.
• W2099627538 cites W1495313272 @default.
• W2099627538 cites W1508982818 @default.
• W2099627538 cites W1923593445 @default.
• W2099627538 cites W1967978173 @default.
• W2099627538 cites W1976207565 @default.
• W2099627538 cites W2007102622 @default.
• W2099627538 cites W2010443735 @default.
• W2099627538 cites W2016071746 @default.
• W2099627538 cites W2018345883 @default.
• W2099627538 cites W2020944660 @default.
• W2099627538 cites W2027702949 @default.
• W2099627538 cites W2030633339 @default.
• W2099627538 cites W2033890123 @default.
• W2099627538 cites W2035394986 @default.
• W2099627538 cites W2042703635 @default.
• W2099627538 cites W2046575058 @default.
• W2099627538 cites W2059368060 @default.
• W2099627538 cites W2060724489 @default.
• W2099627538 cites W2078043779 @default.
• W2099627538 cites W2078961991 @default.
• W2099627538 cites W2090164763 @default.
• W2099627538 cites W2101331206 @default.
• W2099627538 cites W2125228745 @default.
• W2099627538 cites W2127939945 @default.
• W2099627538 cites W2142134806 @default.
• W2099627538 cites W2143369814 @default.
• W2099627538 cites W2169396775 @default.
• W2099627538 cites W2169496899 @default.
• W2099627538 cites W2186467965 @default.
• W2099627538 cites W2188455049 @default.
• W2099627538 cites W2188569672 @default.
• W2099627538 cites W2287312993 @default.
• W2099627538 cites W2340577613 @default.
• W2099627538 cites W2413896196 @default.
• W2099627538 cites W2116049862 @default.
• W2099627538 cites W2408938944 @default.
• W2099627538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15136634" @default.
• W2099627538 hasPublicationYear "2004" @default.
• W2099627538 type Work @default.
• W2099627538 sameAs 2099627538 @default.
• W2099627538 citedByCount "20" @default.
• W2099627538 countsByYear W20996275382012 @default.
• W2099627538 countsByYear W20996275382017 @default.
• W2099627538 countsByYear W20996275382018 @default.
• W2099627538 countsByYear W20996275382022 @default.
• W2099627538 crossrefType "journal-article" @default.
• W2099627538 hasAuthorship W2099627538A5033687321 @default.
• W2099627538 hasAuthorship W2099627538A5037656770 @default.
• W2099627538 hasAuthorship W2099627538A5044095097 @default.
• W2099627538 hasAuthorship W2099627538A5044363701 @default.
• W2099627538 hasAuthorship W2099627538A5049249441 @default.
• W2099627538 hasAuthorship W2099627538A5055131918 @default.
• W2099627538 hasAuthorship W2099627538A5056259111 @default.
• W2099627538 hasAuthorship W2099627538A5078685289 @default.
• W2099627538 hasAuthorship W2099627538A5088003622 @default.
• W2099627538 hasConcept C126322002 @default.
• W2099627538 hasConcept C150903083 @default.
• W2099627538 hasConcept C170493617 @default.
• W2099627538 hasConcept C185592680 @default.
• W2099627538 hasConcept C202751555 @default.
• W2099627538 hasConcept C207001950 @default.
• W2099627538 hasConcept C2775842073 @default.
• W2099627538 hasConcept C2775864247 @default.
• W2099627538 hasConcept C2777807558 @default.
• W2099627538 hasConcept C2778172261 @default.
• W2099627538 hasConcept C2778897192 @default.
• W2099627538 hasConcept C2779190346 @default.
• W2099627538 hasConcept C2984398910 @default.
• W2099627538 hasConcept C2989005 @default.
• W2099627538 hasConcept C55493867 @default.
• W2099627538 hasConcept C60592354 @default.
• W2099627538 hasConcept C71924100 @default.
• W2099627538 hasConcept C75088862 @default.
• W2099627538 hasConcept C86803240 @default.
• W2099627538 hasConceptScore W2099627538C126322002 @default.
• W2099627538 hasConceptScore W2099627538C150903083 @default.
• W2099627538 hasConceptScore W2099627538C170493617 @default.
• W2099627538 hasConceptScore W2099627538C185592680 @default.
• W2099627538 hasConceptScore W2099627538C202751555 @default.
• W2099627538 hasConceptScore W2099627538C207001950 @default.
• W2099627538 hasConceptScore W2099627538C2775842073 @default.
• W2099627538 hasConceptScore W2099627538C2775864247 @default.
• W2099627538 hasConceptScore W2099627538C2777807558 @default.
• W2099627538 hasConceptScore W2099627538C2778172261 @default.

• next