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• W2099642308 abstract "In the primate visual cortex, the birthdate of neurons in homologous layers differ on either side of the 17-18 border suggesting that there might be different timetables of laminar histogenesis in these two areas (Dehay et al. [1993] Nature 366:464–466 and Kennedy et al. [1996] Soc. Neurosci. Abst. 22:525). Because of the potential importance of these findings for understanding mechanisms that generate areal identity, we have developed an experimental approach that makes it possible to accurately compute the timetable of laminar histogenesis from birthdating experiments. Here we report the results of an exhaustive examination of the tempo of layer production in five cortical areas of the mouse. Tritiated thymidine pulse injections were made during embryonic development and labeled neurons were examined in three frontoparietal areas (areas 3, 4, and 6) and two occipital areas (areas 17 and 18a) of the adult cortex. The correlation between the radial distribution of neurons and the intensities of labeling enabled us to reliably identify first generation neurons (i.e., those neurons that quit the cell-cycle in the first round of mitosis after injection). For each cortical layer, the percentage of first generation neurons with respect to the total number of neurons defined a laminar labeling index. Changes of the laminar labeling index over time determined the timetable of layer formation. The onset and duration of layer formation was identical in the two occipital areas. This finding contrasted with the frontoparietal areas where there were important differences in the timing of infragranular and granular layer formation and noticeably production of layers VIa, V, and IV occurs earlier in area 3 than in area 6. The timing of laminar production of areas 17 and 18a resembles more that of area 3 than that of area 6. With respect to areas 3 and 6, area 4 shows an intermediate but significantly different timetable of layer production. These marked areal differences in the timetable of laminar histogenesis contrasted with the relative homogeneity within areas so that we have been able to demonstrate that the interareal differences are not merely the expression of known neurogenic gradients. These results suggest that in the mouse frontoparietal isocortex, neighbouring regions of the ventricular zone that will give rise to distinct areas follow distinct programs of layer production. These areal differences occur before thalamic innervation and suggest an early regionalisation of laminar histogenesis. J. Comp. Neurol. 385:95–116, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2099642308 created "2016-06-24" @default.
• W2099642308 creator A5002062661 @default.
• W2099642308 creator A5038021199 @default.
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• W2099642308 date "1997-08-18" @default.
• W2099642308 modified "2023-10-16" @default.
• W2099642308 title "The timetable of laminar neurogenesis contributes to the specification of cortical areas in mouse isocortex" @default.
• W2099642308 cites W1483007837 @default.
• W2099642308 cites W1484845624 @default.
• W2099642308 cites W1537081661 @default.
• W2099642308 cites W1561541164 @default.
• W2099642308 cites W1574303566 @default.
• W2099642308 cites W1575064426 @default.
• W2099642308 cites W1582081614 @default.
• W2099642308 cites W1766321086 @default.
• W2099642308 cites W1773629427 @default.
• W2099642308 cites W1836854223 @default.
• W2099642308 cites W191076591 @default.
• W2099642308 cites W1916653587 @default.
• W2099642308 cites W1964371761 @default.
• W2099642308 cites W1966266921 @default.
• W2099642308 cites W1967533792 @default.
• W2099642308 cites W1972541892 @default.
• W2099642308 cites W1973303770 @default.
• W2099642308 cites W1976084841 @default.
• W2099642308 cites W1979060895 @default.
• W2099642308 cites W1979531153 @default.
• W2099642308 cites W1979682928 @default.
• W2099642308 cites W1979952856 @default.
• W2099642308 cites W1981164058 @default.
• W2099642308 cites W1981276731 @default.
• W2099642308 cites W1982733952 @default.
• W2099642308 cites W1984376163 @default.
• W2099642308 cites W1988066135 @default.
• W2099642308 cites W1991752595 @default.
• W2099642308 cites W1993208320 @default.
• W2099642308 cites W1994406909 @default.
• W2099642308 cites W1995194777 @default.
• W2099642308 cites W1995953333 @default.
• W2099642308 cites W1996562234 @default.
• W2099642308 cites W1998884675 @default.
• W2099642308 cites W1999450284 @default.
• W2099642308 cites W2001931290 @default.
• W2099642308 cites W2004483817 @default.
• W2099642308 cites W2004902519 @default.
• W2099642308 cites W2005509660 @default.
• W2099642308 cites W2005746771 @default.
• W2099642308 cites W2007251940 @default.
• W2099642308 cites W2011959916 @default.
• W2099642308 cites W2014348091 @default.
• W2099642308 cites W2016855785 @default.
• W2099642308 cites W2019402991 @default.
• W2099642308 cites W2021495455 @default.
• W2099642308 cites W2022274052 @default.
• W2099642308 cites W2022734611 @default.
• W2099642308 cites W2024490431 @default.
• W2099642308 cites W2024760815 @default.
• W2099642308 cites W2027314305 @default.
• W2099642308 cites W2032674296 @default.
• W2099642308 cites W2035017568 @default.
• W2099642308 cites W2036337207 @default.
• W2099642308 cites W2037832186 @default.
• W2099642308 cites W2038913473 @default.
• W2099642308 cites W2042489699 @default.
• W2099642308 cites W2046520081 @default.
• W2099642308 cites W2050394167 @default.
• W2099642308 cites W2054621947 @default.
• W2099642308 cites W2054875089 @default.
• W2099642308 cites W2056823516 @default.
• W2099642308 cites W2059038971 @default.
• W2099642308 cites W2062376214 @default.
• W2099642308 cites W2069845809 @default.
• W2099642308 cites W2070671082 @default.
• W2099642308 cites W2071535176 @default.
• W2099642308 cites W2072673889 @default.
• W2099642308 cites W2076936296 @default.
• W2099642308 cites W2077167737 @default.
• W2099642308 cites W2080570820 @default.
• W2099642308 cites W2081028995 @default.
• W2099642308 cites W2082281194 @default.
• W2099642308 cites W2085462960 @default.
• W2099642308 cites W2089987432 @default.
• W2099642308 cites W2093712120 @default.
• W2099642308 cites W2095184569 @default.
• W2099642308 cites W2102409931 @default.
• W2099642308 cites W2106306931 @default.
• W2099642308 cites W2106352424 @default.
• W2099642308 cites W2114843411 @default.
• W2099642308 cites W2117584148 @default.
• W2099642308 cites W2122384252 @default.
• W2099642308 cites W2127714237 @default.
• W2099642308 cites W2129318325 @default.
• W2099642308 cites W2129824959 @default.
• W2099642308 cites W2130793535 @default.
• W2099642308 cites W2135758711 @default.
• W2099642308 cites W2142003657 @default.
• W2099642308 cites W2142999142 @default.

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