FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099680004> ?p ?o ?g. }

• W2099680004 endingPage "53" @default.
• W2099680004 startingPage "42" @default.
• W2099680004 abstract "That 3alpha-hydroxy-5alpha/beta-pregnane steroids (GABA steroids) have modulatory effects on the GABA-A receptor is well known. In behavioral studies in animals high exogenous dosages give concentrations not usually reached in the brain under physiological conditions. Animal and human studies show that GABA-A receptor-positive modulators like barbiturates, benzodiazepines, alcohol, and allopregnanolone have a bimodal effect. In pharmacological concentrations they are CNS depressants, anesthetic, antiepileptic, and anxiolytic. In low dosages and concentrations, reached endogenously, they can induce adverse emotional reactions in up to 20% of individuals. GABA steroids can also induce tolerance to themselves and similar substances, and rebound occurs at withdrawal. Menstrual cycle-linked disorders can be understood by the concept that they are caused by the action of endogenously produced GABA-steroids through three mechanisms: (a) direct action, (b) tolerance induction, and (c) withdrawal effect. Examples of symptoms and disorders caused by the direct action of GABA steroids are sedation, memory and learning disturbance, clumsiness, increased appetite, worsening of petit mal epilepsy, negative mood as tension, irritability and depression during hormone treatments, and the premenstrual dysphoric disorder (PMDD). A continuous exposure to GABA steroids causes tolerance, and women with PMDD are less sensitive to GABA-A modulators. A malfunctioning GABA-A receptor system is related to stress sensitivity, concentration difficulties, loss of impulse control, irritability, anxiety, and depression. An example of withdrawal effect is catamenial epilepsy, when seizures increase during menstruation after the withdrawal of GABA steroids. Similar phenomena occur at stress since the adrenals produce GABA steroids during stress." @default.
• W2099680004 created "2016-06-24" @default.
• W2099680004 creator A5000155113 @default.
• W2099680004 creator A5001156611 @default.
• W2099680004 creator A5011141133 @default.
• W2099680004 creator A5013006975 @default.
• W2099680004 creator A5044340940 @default.
• W2099680004 creator A5047753878 @default.
• W2099680004 creator A5050091833 @default.
• W2099680004 creator A5053480244 @default.
• W2099680004 creator A5054798161 @default.
• W2099680004 creator A5060350356 @default.
• W2099680004 creator A5060720043 @default.
• W2099680004 creator A5065815798 @default.
• W2099680004 creator A5066421292 @default.
• W2099680004 creator A5069605748 @default.
• W2099680004 creator A5070177200 @default.
• W2099680004 creator A5070973875 @default.
• W2099680004 creator A5072230774 @default.
• W2099680004 creator A5078736873 @default.
• W2099680004 creator A5080336788 @default.
• W2099680004 creator A5090716945 @default.
• W2099680004 creator A5091896026 @default.
• W2099680004 date "2003-12-01" @default.
• W2099680004 modified "2023-10-10" @default.
• W2099680004 title "Pathogenesis in Menstrual Cycle-Linked CNS Disorders" @default.
• W2099680004 cites W1488634403 @default.
• W2099680004 cites W1553661754 @default.
• W2099680004 cites W1575526572 @default.
• W2099680004 cites W1647312149 @default.
• W2099680004 cites W1969104605 @default.
• W2099680004 cites W1970025047 @default.
• W2099680004 cites W1977787204 @default.
• W2099680004 cites W1980751240 @default.
• W2099680004 cites W1989518267 @default.
• W2099680004 cites W1990804897 @default.
• W2099680004 cites W2000904191 @default.
• W2099680004 cites W2001753178 @default.
• W2099680004 cites W2003902982 @default.
• W2099680004 cites W2007019222 @default.
• W2099680004 cites W2008392190 @default.
• W2099680004 cites W2009410204 @default.
• W2099680004 cites W2009415563 @default.
• W2099680004 cites W2012453718 @default.
• W2099680004 cites W2012767314 @default.
• W2099680004 cites W2015423211 @default.
• W2099680004 cites W2017741148 @default.
• W2099680004 cites W2021471098 @default.
• W2099680004 cites W2022761702 @default.
• W2099680004 cites W2022848383 @default.
• W2099680004 cites W2024344189 @default.
• W2099680004 cites W2024566047 @default.
• W2099680004 cites W2027879303 @default.
• W2099680004 cites W2034812041 @default.
• W2099680004 cites W2037046144 @default.
• W2099680004 cites W2037379410 @default.
• W2099680004 cites W2040500197 @default.
• W2099680004 cites W2041296308 @default.
• W2099680004 cites W2043414873 @default.
• W2099680004 cites W2044676056 @default.
• W2099680004 cites W2045355683 @default.
• W2099680004 cites W2046110224 @default.
• W2099680004 cites W2049764374 @default.
• W2099680004 cites W2051629347 @default.
• W2099680004 cites W2058210702 @default.
• W2099680004 cites W2058611708 @default.
• W2099680004 cites W2063995940 @default.
• W2099680004 cites W2070294313 @default.
• W2099680004 cites W2072627631 @default.
• W2099680004 cites W2074439899 @default.
• W2099680004 cites W2077253592 @default.
• W2099680004 cites W2078558962 @default.
• W2099680004 cites W2080641383 @default.
• W2099680004 cites W2082080730 @default.
• W2099680004 cites W2083447043 @default.
• W2099680004 cites W2088604715 @default.
• W2099680004 cites W2090951885 @default.
• W2099680004 cites W2103328620 @default.
• W2099680004 cites W2105739669 @default.
• W2099680004 cites W2115182798 @default.
• W2099680004 cites W2119347851 @default.
• W2099680004 cites W2121587872 @default.
• W2099680004 cites W2123331750 @default.
• W2099680004 cites W2127436611 @default.
• W2099680004 cites W2136916269 @default.
• W2099680004 cites W2140449396 @default.
• W2099680004 cites W2140896143 @default.
• W2099680004 cites W2147682916 @default.
• W2099680004 cites W2157744185 @default.
• W2099680004 cites W2163191129 @default.
• W2099680004 cites W2168540482 @default.
• W2099680004 cites W2169213189 @default.
• W2099680004 cites W2170244784 @default.
• W2099680004 cites W2316154595 @default.
• W2099680004 cites W2334920044 @default.
• W2099680004 cites W3158160561 @default.
• W2099680004 cites W4231367257 @default.
• W2099680004 cites W4233635697 @default.

• next