FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099681945> ?p ?o ?g. }

• W2099681945 endingPage "2366" @default.
• W2099681945 startingPage "2359" @default.
• W2099681945 abstract "Dorsal-ventral patterning in vertebrate embryos is regulated by members of the TGF-beta family of growth and differentiation factors. In Xenopus the activins and Vg1 are potent dorsal mesoderm inducers while members of the bone morphogenetic protein (BMP) subclass pattern ventral mesoderm and regulate ectodermal cell fates. Receptors for ligands in the TGF-beta superfamily are serine-threonine kinases, but little is known about the components of the signal transduction pathway leading away from these receptors. In Drosophila the decapentaplegic protein (dpp), a homolog of vertebrate BMP-2 and BMP-4, functions in dorsal-ventral axial patterning, and a genetic screen for components involved in signaling by dpp has identified a gene named mothers against decapentaplegic (Mad). Mad encodes a unique, predicted cytoplasmic, protein containing no readily identified functional motifs. This report demonstrates that a gene closely related to Drosophila Mad exists in Xenopus (called XMad) and it exhibits activities consistent with a role in BMP signaling. XMad protein induces ventral mesoderm when overexpressed in isolated animal caps and it ventralizes embryos. Furthermore, XMad rescues phenotypes generated by a signaling-defective, dominant-negative, BMP-2/4 receptor. These results furnish evidence that XMad protein participates in vertebrate embryonic dorsal-ventral patterning by functioning in BMP-2/4 receptor signal transduction." @default.
• W2099681945 created "2016-06-24" @default.
• W2099681945 creator A5025099877 @default.
• W2099681945 date "1996-08-01" @default.
• W2099681945 modified "2023-10-14" @default.
• W2099681945 title "<i>Xenopus mothers against decapentaplegic</i> is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor" @default.
• W2099681945 cites W1488242188 @default.
• W2099681945 cites W1494055834 @default.
• W2099681945 cites W1530364143 @default.
• W2099681945 cites W1563545224 @default.
• W2099681945 cites W1594765203 @default.
• W2099681945 cites W1606814949 @default.
• W2099681945 cites W1911890413 @default.
• W2099681945 cites W1973812449 @default.
• W2099681945 cites W1974162083 @default.
• W2099681945 cites W1976353556 @default.
• W2099681945 cites W1978308857 @default.
• W2099681945 cites W1979506161 @default.
• W2099681945 cites W1981177192 @default.
• W2099681945 cites W1983086133 @default.
• W2099681945 cites W1993154580 @default.
• W2099681945 cites W1995560695 @default.
• W2099681945 cites W2006322727 @default.
• W2099681945 cites W2010206624 @default.
• W2099681945 cites W2011175428 @default.
• W2099681945 cites W2024279589 @default.
• W2099681945 cites W2024514628 @default.
• W2099681945 cites W2024946238 @default.
• W2099681945 cites W2027432488 @default.
• W2099681945 cites W2038073573 @default.
• W2099681945 cites W2040306164 @default.
• W2099681945 cites W2041823687 @default.
• W2099681945 cites W2046597024 @default.
• W2099681945 cites W2056050429 @default.
• W2099681945 cites W2066248992 @default.
• W2099681945 cites W2068132469 @default.
• W2099681945 cites W2070849620 @default.
• W2099681945 cites W2074597244 @default.
• W2099681945 cites W2076023969 @default.
• W2099681945 cites W2081956249 @default.
• W2099681945 cites W2092911887 @default.
• W2099681945 cites W2096590212 @default.
• W2099681945 cites W2100522747 @default.
• W2099681945 cites W2105884976 @default.
• W2099681945 cites W2107141327 @default.
• W2099681945 cites W2125068279 @default.
• W2099681945 cites W2130662470 @default.
• W2099681945 cites W2138270253 @default.
• W2099681945 cites W2144446831 @default.
• W2099681945 cites W2185643875 @default.
• W2099681945 cites W2205083200 @default.
• W2099681945 cites W2234549232 @default.
• W2099681945 cites W2294929520 @default.
• W2099681945 cites W2347083990 @default.
• W2099681945 cites W2424345117 @default.
• W2099681945 cites W4321429223 @default.
• W2099681945 doi "https://doi.org/10.1242/dev.122.8.2359" @default.
• W2099681945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8756281" @default.
• W2099681945 hasPublicationYear "1996" @default.
• W2099681945 type Work @default.
• W2099681945 sameAs 2099681945 @default.
• W2099681945 citedByCount "162" @default.
• W2099681945 countsByYear W20996819452012 @default.
• W2099681945 countsByYear W20996819452014 @default.
• W2099681945 countsByYear W20996819452017 @default.
• W2099681945 countsByYear W20996819452020 @default.
• W2099681945 crossrefType "journal-article" @default.
• W2099681945 hasAuthorship W2099681945A5025099877 @default.
• W2099681945 hasConcept C104317684 @default.
• W2099681945 hasConcept C145103041 @default.
• W2099681945 hasConcept C2776735322 @default.
• W2099681945 hasConcept C2779535977 @default.
• W2099681945 hasConcept C2780104201 @default.
• W2099681945 hasConcept C2780915607 @default.
• W2099681945 hasConcept C31507581 @default.
• W2099681945 hasConcept C54355233 @default.
• W2099681945 hasConcept C62478195 @default.
• W2099681945 hasConcept C73834784 @default.
• W2099681945 hasConcept C86803240 @default.
• W2099681945 hasConcept C91986751 @default.
• W2099681945 hasConcept C95444343 @default.
• W2099681945 hasConceptScore W2099681945C104317684 @default.
• W2099681945 hasConceptScore W2099681945C145103041 @default.
• W2099681945 hasConceptScore W2099681945C2776735322 @default.
• W2099681945 hasConceptScore W2099681945C2779535977 @default.
• W2099681945 hasConceptScore W2099681945C2780104201 @default.
• W2099681945 hasConceptScore W2099681945C2780915607 @default.
• W2099681945 hasConceptScore W2099681945C31507581 @default.
• W2099681945 hasConceptScore W2099681945C54355233 @default.
• W2099681945 hasConceptScore W2099681945C62478195 @default.
• W2099681945 hasConceptScore W2099681945C73834784 @default.
• W2099681945 hasConceptScore W2099681945C86803240 @default.
• W2099681945 hasConceptScore W2099681945C91986751 @default.
• W2099681945 hasConceptScore W2099681945C95444343 @default.
• W2099681945 hasIssue "8" @default.
• W2099681945 hasLocation W20996819451 @default.
• W2099681945 hasLocation W20996819452 @default.
• W2099681945 hasOpenAccess W2099681945 @default.

• next