FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099682100> ?p ?o ?g. }

• W2099682100 endingPage "e56116" @default.
• W2099682100 startingPage "e56116" @default.
• W2099682100 abstract "Hepatic stellate cells (HSCs) play a major role in the pathogenesis of liver fibrosis. Working on primary HSCs requires difficult isolation procedures; therefore we have generated and here characterize a mouse hepatic stellate cell line expressing GFP under control of the collagen 1(I) promoter/enhancer. These cells are responsive to pro-fibrogenic stimuIi, such as PDGF or TGF-β1, and are able to activate intracellular signalling pathways including Smads and MAP kinases. Nevertheless, due to the basal level of activation, TGF-β1 did not significantly induce GFP expression contrasting the TGF-β1 regulated endogenous collagen I expression. We could demonstrate that the accessory TGF-β-receptor endoglin, which is endogenously expressed at very low levels, has a differential effect on signalling of these cells when transiently overexpressed. In the presence of endoglin activation of Smad1/5/8 was drastically enhanced. Moreover, the phosphorylation of ERK1/2 was increased, and the expression of vimentin, α-smooth muscle actin and connective tissue growth factor was upregulated. Endoglin induced a slight increase in expression of the inhibitor of differentiation-2 while the amount of endogenous collagen type I was reduced. Therefore, this profibrogenic cell line with hepatic stellate cell origin is not only a promising novel experimental tool, which can be used in vivo for cell tracing experiments. Furthermore it allows investigating the impact of various regulatory proteins (e.g. endoglin) on profibrogenic signal transduction, differentiation and hepatic stellate cell biology." @default.
• W2099682100 created "2016-06-24" @default.
• W2099682100 creator A5003455999 @default.
• W2099682100 creator A5006242340 @default.
• W2099682100 creator A5027968167 @default.
• W2099682100 creator A5032402107 @default.
• W2099682100 creator A5035647487 @default.
• W2099682100 creator A5055719124 @default.
• W2099682100 creator A5067699379 @default.
• W2099682100 creator A5069198374 @default.
• W2099682100 creator A5087817221 @default.
• W2099682100 date "2013-02-20" @default.
• W2099682100 modified "2023-10-13" @default.
• W2099682100 title "Overexpression of Endoglin Modulates TGF-β1-Signalling Pathways in a Novel Immortalized Mouse Hepatic Stellate Cell Line" @default.
• W2099682100 cites W1523878042 @default.
• W2099682100 cites W1960272757 @default.
• W2099682100 cites W1980325398 @default.
• W2099682100 cites W1988047146 @default.
• W2099682100 cites W1997133459 @default.
• W2099682100 cites W2001575993 @default.
• W2099682100 cites W2002733746 @default.
• W2099682100 cites W2003608352 @default.
• W2099682100 cites W2004121042 @default.
• W2099682100 cites W2011285940 @default.
• W2099682100 cites W2012260101 @default.
• W2099682100 cites W2018225189 @default.
• W2099682100 cites W2022659261 @default.
• W2099682100 cites W2023952437 @default.
• W2099682100 cites W2024040797 @default.
• W2099682100 cites W2026025275 @default.
• W2099682100 cites W2030225842 @default.
• W2099682100 cites W2032228059 @default.
• W2099682100 cites W2034705121 @default.
• W2099682100 cites W2037320477 @default.
• W2099682100 cites W2039426167 @default.
• W2099682100 cites W2059284026 @default.
• W2099682100 cites W2074078019 @default.
• W2099682100 cites W2081827418 @default.
• W2099682100 cites W2088724129 @default.
• W2099682100 cites W2091764094 @default.
• W2099682100 cites W2092824717 @default.
• W2099682100 cites W2093733315 @default.
• W2099682100 cites W2095025412 @default.
• W2099682100 cites W2104551096 @default.
• W2099682100 cites W2107922244 @default.
• W2099682100 cites W2110338837 @default.
• W2099682100 cites W2111288662 @default.
• W2099682100 cites W2116348824 @default.
• W2099682100 cites W2123137262 @default.
• W2099682100 cites W2127481999 @default.
• W2099682100 cites W2128005193 @default.
• W2099682100 cites W2130460321 @default.
• W2099682100 cites W2153516472 @default.
• W2099682100 cites W2154568166 @default.
• W2099682100 cites W2165062244 @default.
• W2099682100 cites W2165927567 @default.
• W2099682100 cites W2316067769 @default.
• W2099682100 cites W4250450758 @default.
• W2099682100 cites W4255712601 @default.
• W2099682100 cites W4313197481 @default.
• W2099682100 doi "https://doi.org/10.1371/journal.pone.0056116" @default.
• W2099682100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3577806" @default.
• W2099682100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23437087" @default.
• W2099682100 hasPublicationYear "2013" @default.
• W2099682100 type Work @default.
• W2099682100 sameAs 2099682100 @default.
• W2099682100 citedByCount "38" @default.
• W2099682100 countsByYear W20996821002014 @default.
• W2099682100 countsByYear W20996821002015 @default.
• W2099682100 countsByYear W20996821002016 @default.
• W2099682100 countsByYear W20996821002017 @default.
• W2099682100 countsByYear W20996821002018 @default.
• W2099682100 countsByYear W20996821002019 @default.
• W2099682100 countsByYear W20996821002020 @default.
• W2099682100 countsByYear W20996821002021 @default.
• W2099682100 countsByYear W20996821002022 @default.
• W2099682100 countsByYear W20996821002023 @default.
• W2099682100 crossrefType "journal-article" @default.
• W2099682100 hasAuthorship W2099682100A5003455999 @default.
• W2099682100 hasAuthorship W2099682100A5006242340 @default.
• W2099682100 hasAuthorship W2099682100A5027968167 @default.
• W2099682100 hasAuthorship W2099682100A5032402107 @default.
• W2099682100 hasAuthorship W2099682100A5035647487 @default.
• W2099682100 hasAuthorship W2099682100A5055719124 @default.
• W2099682100 hasAuthorship W2099682100A5067699379 @default.
• W2099682100 hasAuthorship W2099682100A5069198374 @default.
• W2099682100 hasAuthorship W2099682100A5087817221 @default.
• W2099682100 hasBestOaLocation W20996821001 @default.
• W2099682100 hasConcept C10205521 @default.
• W2099682100 hasConcept C118131993 @default.
• W2099682100 hasConcept C134018914 @default.
• W2099682100 hasConcept C153911025 @default.
• W2099682100 hasConcept C176891718 @default.
• W2099682100 hasConcept C2778229498 @default.
• W2099682100 hasConcept C28328180 @default.
• W2099682100 hasConcept C54355233 @default.
• W2099682100 hasConcept C6061869 @default.
• W2099682100 hasConcept C62478195 @default.

• next