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- W2099682888 abstract "It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin. The inhibition by flavan-3-ols and procyanidins was competitive with the two substrates assayed: N-hippuryl-L-histidyl-L-leucine (HHL) and N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG). Tetramer and hexamer fractions were the more potent inhibitors, showing Ki of 5.6 and 4.7 microM, respectively. As ACE is a membrane protein, the interaction of flavanols and procyanidins with the enzyme could be related to the number of hydroxyl groups on the procyanidins, which determine their capacity to be adsorbed on the membrane surface." @default.
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- W2099682888 date "2003-11-27" @default.
- W2099682888 modified "2023-10-10" @default.
- W2099682888 title "Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins" @default.
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- W2099682888 doi "https://doi.org/10.1016/s0014-5793(03)01355-3" @default.
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