FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099683645> ?p ?o ?g. }

• W2099683645 abstract "One of the most dreaded complications of septic shock is acute kidney injury. It occurs in around 50% of patients, with a mortality rate of about 60% at 3 months. There is no consensus on the optimal time to initiate renal replacement therapy. Retrospective and observational studies suggest that early implementation of renal replacement therapy could improve the prognosis for these patients. This protocol summarizes the rationale and design of a randomized, controlled, multicenter trial investigating the effect of early versus delayed renal replacement therapy in patients with severe acute kidney injury in early septic shock. In total, 864 critically ill adults with septic shock and evidence of acute kidney injury, defined as the failure stage of the RIFLE classification, will be enrolled. The primary outcome is mortality at 90 days. Secondary outcomes include safety, number of days free of mechanical ventilation, number of days free of renal replacement therapy, intensive care length of stay, in-hospital length of stay, quality of life as evaluated by the EQ-5D and renal replacement therapy dependence at hospital discharge. The primary analysis will be intention to treat. Recruitment started in March 2012 and will be completed by March 2015. This protocol for a randomized controlled study investigating the impact of the timing of renal replacement therapy initiation should provide an answer to a key question for the management of patients with acute kidney injury in the context of septic shock, for whom the mortality rate remains close to 60% despite improved understanding of physiopathology and recent therapeutic advances. ClinicalTrials.gov identifier NCT01682590 , registered on 10 September 2012." @default.
• W2099683645 created "2016-06-24" @default.
• W2099683645 creator A5009731288 @default.
• W2099683645 creator A5036864107 @default.
• W2099683645 creator A5056140361 @default.
• W2099683645 creator A5086344364 @default.
• W2099683645 creator A5086633984 @default.
• W2099683645 date "2014-07-07" @default.
• W2099683645 modified "2023-09-30" @default.
• W2099683645 title "Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial" @default.
• W2099683645 cites W1490672039 @default.
• W2099683645 cites W1967300023 @default.
• W2099683645 cites W1970593590 @default.
• W2099683645 cites W1980228387 @default.
• W2099683645 cites W1987564286 @default.
• W2099683645 cites W1999680982 @default.
• W2099683645 cites W2010422428 @default.
• W2099683645 cites W2013256551 @default.
• W2099683645 cites W2026332974 @default.
• W2099683645 cites W2030399183 @default.
• W2099683645 cites W2044462438 @default.
• W2099683645 cites W2044664374 @default.
• W2099683645 cites W2047326606 @default.
• W2099683645 cites W2057159770 @default.
• W2099683645 cites W2058350585 @default.
• W2099683645 cites W2067199569 @default.
• W2099683645 cites W2069036995 @default.
• W2099683645 cites W2088699193 @default.
• W2099683645 cites W2096254099 @default.
• W2099683645 cites W2099857640 @default.
• W2099683645 cites W2112353268 @default.
• W2099683645 cites W2117414166 @default.
• W2099683645 cites W2117958746 @default.
• W2099683645 cites W2119585617 @default.
• W2099683645 cites W2134128095 @default.
• W2099683645 cites W2135765082 @default.
• W2099683645 cites W2138888160 @default.
• W2099683645 cites W2139937737 @default.
• W2099683645 cites W2149687213 @default.
• W2099683645 cites W2150758178 @default.
• W2099683645 cites W2151517451 @default.
• W2099683645 cites W2153836018 @default.
• W2099683645 cites W2156058032 @default.
• W2099683645 cites W2156916779 @default.
• W2099683645 cites W2157507874 @default.
• W2099683645 cites W2158203186 @default.
• W2099683645 cites W2159437578 @default.
• W2099683645 cites W2442246762 @default.
• W2099683645 doi "https://doi.org/10.1186/1745-6215-15-270" @default.
• W2099683645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4226975" @default.
• W2099683645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24998258" @default.
• W2099683645 hasPublicationYear "2014" @default.
• W2099683645 type Work @default.
• W2099683645 sameAs 2099683645 @default.
• W2099683645 citedByCount "76" @default.
• W2099683645 countsByYear W20996836452014 @default.
• W2099683645 countsByYear W20996836452015 @default.
• W2099683645 countsByYear W20996836452016 @default.
• W2099683645 countsByYear W20996836452017 @default.
• W2099683645 countsByYear W20996836452018 @default.
• W2099683645 countsByYear W20996836452019 @default.
• W2099683645 countsByYear W20996836452020 @default.
• W2099683645 countsByYear W20996836452021 @default.
• W2099683645 countsByYear W20996836452022 @default.
• W2099683645 countsByYear W20996836452023 @default.
• W2099683645 crossrefType "journal-article" @default.
• W2099683645 hasAuthorship W2099683645A5009731288 @default.
• W2099683645 hasAuthorship W2099683645A5036864107 @default.
• W2099683645 hasAuthorship W2099683645A5056140361 @default.
• W2099683645 hasAuthorship W2099683645A5086344364 @default.
• W2099683645 hasAuthorship W2099683645A5086633984 @default.
• W2099683645 hasBestOaLocation W20996836451 @default.
• W2099683645 hasConcept C126322002 @default.
• W2099683645 hasConcept C151730666 @default.
• W2099683645 hasConcept C166957645 @default.
• W2099683645 hasConcept C168563851 @default.
• W2099683645 hasConcept C177713679 @default.
• W2099683645 hasConcept C179755657 @default.
• W2099683645 hasConcept C23131810 @default.
• W2099683645 hasConcept C2777051993 @default.
• W2099683645 hasConcept C2777080012 @default.
• W2099683645 hasConcept C2777628635 @default.
• W2099683645 hasConcept C2778384902 @default.
• W2099683645 hasConcept C2779343474 @default.
• W2099683645 hasConcept C2779541074 @default.
• W2099683645 hasConcept C2779978075 @default.
• W2099683645 hasConcept C2780472472 @default.
• W2099683645 hasConcept C2781300812 @default.
• W2099683645 hasConcept C71924100 @default.
• W2099683645 hasConcept C86803240 @default.
• W2099683645 hasConcept C95457728 @default.
• W2099683645 hasConceptScore W2099683645C126322002 @default.
• W2099683645 hasConceptScore W2099683645C151730666 @default.
• W2099683645 hasConceptScore W2099683645C166957645 @default.
• W2099683645 hasConceptScore W2099683645C168563851 @default.
• W2099683645 hasConceptScore W2099683645C177713679 @default.
• W2099683645 hasConceptScore W2099683645C179755657 @default.
• W2099683645 hasConceptScore W2099683645C23131810 @default.
• W2099683645 hasConceptScore W2099683645C2777051993 @default.
• W2099683645 hasConceptScore W2099683645C2777080012 @default.

• next