FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099684738> ?p ?o ?g. }

• W2099684738 endingPage "2088" @default.
• W2099684738 startingPage "2077" @default.
• W2099684738 abstract "Connexin43 is a member of the highly homologous connexin family of gap junction proteins. We have studied how connexin monomers are assembled into functional gap junction plaques by examining the biosynthesis of connexin43 in cell types that differ greatly in their ability to form functional gap junctions. Using a combination of metabolic radiolabeling and immunoprecipitation, we have shown that connexin43 is synthesized in gap junctional communication-competent cells as a 42-kD protein that is efficiently converted to a approximately 46-kD species (connexin43-P2) by the posttranslational addition of phosphate. Surprisingly, certain cell lines severely deficient in gap junctional communication and known cell-cell adhesion molecules (S180 and L929 cells) also expressed 42-kD connexin43. Connexin43 in these communication-deficient cell lines was not, however, phosphorylated to the P2 form. Conversion of S180 cells to a communication-competent phenotype by transfection with a cDNA encoding the cell-cell adhesion molecule L-CAM induced phosphorylation of connexin43 to the P2 form; conversely, blocking junctional communication in ordinarily communication-competent cells inhibited connexin43-P2 formation. Immunohistochemical localization studies indicated that only communication-competent cells accumulated connexin43 in visible gap junction plaques. Together, these results establish a strong correlation between the ability of cells to process connexin43 to the P2 form and to produce functional gap junctions. Connexin43 phosphorylation may therefore play a functional role in gap junction assembly and/or activity." @default.
• W2099684738 created "2016-06-24" @default.
• W2099684738 creator A5022425980 @default.
• W2099684738 creator A5035814482 @default.
• W2099684738 creator A5070309801 @default.
• W2099684738 creator A5071984892 @default.
• W2099684738 date "1990-11-01" @default.
• W2099684738 modified "2023-10-13" @default.
• W2099684738 title "Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines." @default.
• W2099684738 cites W1509216925 @default.
• W2099684738 cites W1582796640 @default.
• W2099684738 cites W1616609814 @default.
• W2099684738 cites W163747120 @default.
• W2099684738 cites W1932563008 @default.
• W2099684738 cites W1973163251 @default.
• W2099684738 cites W1975602477 @default.
• W2099684738 cites W1978994382 @default.
• W2099684738 cites W1979204241 @default.
• W2099684738 cites W1982923513 @default.
• W2099684738 cites W1983887397 @default.
• W2099684738 cites W1989982202 @default.
• W2099684738 cites W1992689315 @default.
• W2099684738 cites W1992706415 @default.
• W2099684738 cites W1995044396 @default.
• W2099684738 cites W1996938276 @default.
• W2099684738 cites W2000063742 @default.
• W2099684738 cites W2001578819 @default.
• W2099684738 cites W2006905166 @default.
• W2099684738 cites W2012654459 @default.
• W2099684738 cites W2014669590 @default.
• W2099684738 cites W2018289835 @default.
• W2099684738 cites W2022963363 @default.
• W2099684738 cites W2030743632 @default.
• W2099684738 cites W2038155115 @default.
• W2099684738 cites W2045709891 @default.
• W2099684738 cites W2047002972 @default.
• W2099684738 cites W2049176532 @default.
• W2099684738 cites W2052438223 @default.
• W2099684738 cites W2054707772 @default.
• W2099684738 cites W2055762046 @default.
• W2099684738 cites W2056741720 @default.
• W2099684738 cites W2060333964 @default.
• W2099684738 cites W2060362929 @default.
• W2099684738 cites W2060693006 @default.
• W2099684738 cites W2061527200 @default.
• W2099684738 cites W2063061829 @default.
• W2099684738 cites W2064692804 @default.
• W2099684738 cites W2064864270 @default.
• W2099684738 cites W2068771990 @default.
• W2099684738 cites W2076251639 @default.
• W2099684738 cites W2077660651 @default.
• W2099684738 cites W2081492347 @default.
• W2099684738 cites W2086080160 @default.
• W2099684738 cites W2086124604 @default.
• W2099684738 cites W2086735876 @default.
• W2099684738 cites W2086973193 @default.
• W2099684738 cites W2088130063 @default.
• W2099684738 cites W2089800175 @default.
• W2099684738 cites W2090289611 @default.
• W2099684738 cites W2100837269 @default.
• W2099684738 cites W2103174300 @default.
• W2099684738 cites W2114540884 @default.
• W2099684738 cites W2123929920 @default.
• W2099684738 cites W2126154316 @default.
• W2099684738 cites W2137820120 @default.
• W2099684738 cites W2238683554 @default.
• W2099684738 cites W2395920243 @default.
• W2099684738 cites W2412384313 @default.
• W2099684738 cites W4254179074 @default.
• W2099684738 doi "https://doi.org/10.1083/jcb.111.5.2077" @default.
• W2099684738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2116332" @default.
• W2099684738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2172261" @default.
• W2099684738 hasPublicationYear "1990" @default.
• W2099684738 type Work @default.
• W2099684738 sameAs 2099684738 @default.
• W2099684738 citedByCount "671" @default.
• W2099684738 countsByYear W20996847382012 @default.
• W2099684738 countsByYear W20996847382013 @default.
• W2099684738 countsByYear W20996847382014 @default.
• W2099684738 countsByYear W20996847382015 @default.
• W2099684738 countsByYear W20996847382016 @default.
• W2099684738 countsByYear W20996847382017 @default.
• W2099684738 countsByYear W20996847382018 @default.
• W2099684738 countsByYear W20996847382019 @default.
• W2099684738 countsByYear W20996847382020 @default.
• W2099684738 countsByYear W20996847382021 @default.
• W2099684738 countsByYear W20996847382022 @default.
• W2099684738 countsByYear W20996847382023 @default.
• W2099684738 crossrefType "journal-article" @default.
• W2099684738 hasAuthorship W2099684738A5022425980 @default.
• W2099684738 hasAuthorship W2099684738A5035814482 @default.
• W2099684738 hasAuthorship W2099684738A5070309801 @default.
• W2099684738 hasAuthorship W2099684738A5071984892 @default.
• W2099684738 hasBestOaLocation W20996847381 @default.
• W2099684738 hasConcept C11960822 @default.
• W2099684738 hasConcept C1491633281 @default.
• W2099684738 hasConcept C150555746 @default.
• W2099684738 hasConcept C158157758 @default.

• next